Beyond Conventional Transcriptional Regulation Function: FOXP3 as an Integrative Hub for Chromatin Interactions and Protein Complexes in Immune Regulation

Simple Summary Regulatory T cells (Tregs), a distinct subset of CD4+ T lymphocytes, play indispensable roles in restraining immune responses to sustain immune tolerance and prevent excessive inflammation. The Forkhead box transcription factor FOXP3 serves as the master regulator for the development and function of regulatory T cells. Understanding how FOXP3 exerts its regulatory functions across various biological settings remains a major research focus. Current findings reveal that FOXP3 interacts with diverse context-dependent cofactors and utilizes its DNA-bridging capacity to mediate long-range chromatin interactions. Thus, FOXP3 represents a novel class of transcription factor that functions as a multimodal interaction hub, integrating diverse signals to dynamically coordinate global gene expression, a paradigm distinct from its previously defined role as a conventional and single-acting transcription factor.

• Publication year

  2026

• Venue

  Biology

• Publication date

  2026-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/biology15030254PMID 41677725PMCID 12896633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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