Study on biomarkers of homocysteine-induced transformation of vascular smooth muscle cells into foam cells

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Scientific Reports

• Publication date

  2026-02-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/s41598-026-38763-6PMID 41644998PMCID PMC12929605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

  2025cited by this paper
• Altered mitochondrial unfolded protein response and FGF21 secretion in MASLD progression and the effect of exercise intervention

  2025cited by this paper
• Regulation of mitochondrial oxidative phosphorylation through tight control of cytochrome c oxidase in health and disease – Implications for ischemia/reperfusion injury, inflammatory diseases, diabetes, and cancer

  2024cited by this paper
• The PRIDE database at 20 years: 2025 update

  2024cited by this paper
• Rethinking atherosclerotic cardiovascular disease prevention in the era of expanding therapies: could plaque stabilization reduce the need for lifelong treatments and polypharmacy?

  2024cited by this paper
• The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity

  2024cited by this paper
• Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3

  2024cited by this paper
• Effect of Dl-3-n-butylphthalide on mitochondrial Cox7c in models of cerebral ischemia/reperfusion injury

  2023cited by this paper
• Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration

  2023cited by this paper
• Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets

  2023cited by this paper
• Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress

  2023influential reference
• Homocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: a systematic review and meta-analysis.

  2023cited by this paper
• Recent Advances for Dynamic-Based Therapy of Atherosclerosis

  2023cited by this paper
• Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder

  2023cited by this paper
• Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.

  2023cited by this paper
• Pathophysiology of Atherosclerosis

  2022cited by this paper
• KEGG for taxonomy-based analysis of pathways and genomes

  2022cited by this paper
• Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations

  2022cited by this paper
• Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

  2022cited by this paper
• Dietary Choline Alleviates High-Fat Diet-Induced Hepatic Lipid Dysregulation via UPRmt Modulated by SIRT3-Mediated mtHSP70 Deacetylation

  2022cited by this paper
• Mitochondrial ROS Produced by Skeletal Muscle Mitochondria Promote the Decisive Signal for UPRmt Activation

  2022cited by this paper
• 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

  2021cited by this paper
• Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

  2021cited by this paper
• Vascular smooth muscle cells in atherosclerosis:Time for a reassessment.

  2021cited by this paper
• NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90

  2020cited by this paper
• ESC / EAS Guidelines for the Treatment of Dyslipidemias: Lipid Modification to Reduce Cardiovascular Risk

  2020cited by this paper
• Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems

  2020cited by this paper
• Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis

  2020cited by this paper
• Calcified decellularized arterial scaffolds impact vascular smooth muscle cell transformation via downregulating α-SMA expression and upregulating OPN expression.

  2019cited by this paper
• Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis

  2019cited by this paper
• Mitochondrial Dysfunction in Atherosclerosis

  2019cited by this paper
• Aberrant MFN2 transcription facilitates homocysteine‐induced VSMCs proliferation via the increased binding of c‐Myc to DNMT1 in atherosclerosis

  2019cited by this paper
• Stx5-Mediated ER-Golgi Transport in Mammals and Yeast

  2019cited by this paper
• Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway.

  2019cited by this paper
• Role of the Balance of Akt and MAPK Pathways in the Exercise-Regulated Phenotype Switching in Spontaneously Hypertensive Rats

  2019cited by this paper
• Targeting autophagy-related protein kinases for potential therapeutic purpose

  2019cited by this paper
• 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.

  2019cited by this paper
• Metformin treatment prevents SREBP2‐mediated cholesterol uptake and improves lipid homeostasis during oxidative stress‐induced atherosclerosis

  2018cited by this paper
• Pitx2 maintains mitochondrial function during regeneration to prevent myocardial fat deposition

  2018cited by this paper
• Lipid transfer proteins in the assembly of apoB-containing lipoproteins

  2018cited by this paper
• microRNA let‐7g suppresses PDGF‐induced conversion of vascular smooth muscle cell into the synthetic phenotype

  2017cited by this paper
• Raf Kinase Inhibitor Protein (RKIP) Inhibits Tumor Necrosis Factor-α (TNF-α) Induced Adhesion Molecules Expression in Vascular Smooth Muscle Bells by Suppressing (Nuclear Transcription Factor-κB (NF-kappaB) Pathway

  2017cited by this paper
• Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis

  2016cited by this paper
• Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools.

  2016cited by this paper
• SNARE-Mediated Cholesterol Movement to Mitochondria Supports Steroidogenesis in Rodent Cells.

  2016cited by this paper
• NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress

  2016cited by this paper
• The role of glutathione reductase and related enzymes on cellular redox homoeostasis network.

  2016cited by this paper
• High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/− mice

  2015cited by this paper
• Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.

  2015cited by this paper
• The subunit composition and function of mammalian cytochrome c oxidase.

  2015cited by this paper
• Apolipoprotein B, the villain in the drama?

  2015cited by this paper
• Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

  2014cited by this paper
• Effects of rosuvastatin on the production and activation of matrix metalloproteinase-2 and migration of cultured rat vascular smooth muscle cells induced by homocysteine

  2013cited by this paper
• Increased Intestinal Lipid Absorption Caused by Ire1&bgr; Deficiency Contributes to Hyperlipidemia and Atherosclerosis in Apolipoprotein E–Deficient Mice

  2012cited by this paper
• Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation[S]

  2012cited by this paper
• Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

  2011cited by this paper
• A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

  2011cited by this paper
• Homocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox.

  2010cited by this paper
• Chemical pathology of homocysteine. IV. Excitotoxicity, oxidative stress, endothelial dysfunction, and inflammation.

  2009cited by this paper
• Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin.

  2009cited by this paper
• Increased Expression of Glutathione Reductase in Macrophages Decreases Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice

  2007cited by this paper
• Mitochondrial Dysfunction in Atherosclerosis

  2007cited by this paper
• Critical role of Mst1 in vascular remodeling after injury

  2006cited by this paper
• Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells.

  1999cited by this paper
• Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells

  1999cited by this paper
• Homocysteine and atherothrombosis.

  1998cited by this paper
• A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.

  1995cited by this paper
• Regulation of differentiation of vascular smooth muscle cells.

  1995cited by this paper

• No citing papers are available for this paper.