Recent advances in plant polyphenol-based adhesive hydrogels for biomedical applications.

Plant polyphenol-based hydrogels have gained widespread attention due to their unique and outstanding properties such as adhesion, antibacterial, self-healing and biocompatibility. The adhesion performance of these hydrogels can be systematically engineered to meet specific requirements, demonstrating significant potential in biomedical applications. This review initially explores the design strategies of hydrogels derived from different plant polyphenols. Subsequently, the multiple adhesive properties imparted by diverse design strategies, including dry adhesion, underwater adhesion, switchable adhesion, specific adhesion and asymmetrical adhesion are discussed. In addition, biomedical applications of plant polyphenol-based adhesive hydrogels, focusing on wound dressings, therapeutic drug delivery, cartilage tissue scaffolds and wearable electronics are summarized. In the end, remaining challenges and outline prospects for future research are discussed. It is hoped that this review can provide new innovation into the development of plant polyphenol-based adhesive hydrogels.

• Publication year

  2026

• Venue

  Biomaterials Advances

• Publication date

  2026-02-03

• Fields of study

  Biology, Medicine, Materials Science

• Identifiers
  DOI 10.1016/j.bioadv.2026.214757PMID 41653760
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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