Identification of a Novel Missense Homozygous Variant in LINS1 in Two Distinct Iranian Families With Consanguineous Marriage

LINS1, the human homolog of the Drosophila segment polarity gene, encodes a key regulator of the Wingless/Wnt signaling pathway. While numerous genes have been implicated in intellectual disability (ID), only a limited number have been conclusively associated with autosomal recessive intellectual disability (ARID). Variants in LINS1 have been identified as one such cause.

• Publication year

  2026

• Venue

  Molecular Genetics & Genomic Medicine

• Publication date

  2026-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mgg3.70184PMID 41656075PMCID 12883300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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