Mitochondrial Functions in Mood Disorders

Depression is a serious mental disorder manifested by depressed mood, pessimistic thoughts, feelings of worthlessness, feelings of guilt, tearfulness, reduced or increased sleep, appetite loss or appetite disturbance, weight loss or weight gain, social restlessness, loss of interest, difficulty concentrating. Mania is characterized by abnormally elevated or irritable mood, arousal, and/or energy levels. Bipolar disorder features intermittent episodes of ma‐ nia or hypomania and depressive episodes; rapid cycling, mixed states, and psychotic symp‐ toms occuring in some cases. Depression and mania are thought to be heterogeneous illnesses that can result from dysfunction of several neurotransmitters or metabolic systems.

• Publication year

  2013

• Venue

  Unknown venue

• Publication date

  2013-01-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.5772/53254
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Mitochondrial dysfunction induced by sertraline, an antidepressant agent.

  2012influential reference
• The neurobiology of depression.

  2012cited by this paper
• Psychiatric disorders and mitochondrial dysfunctions.

  2012cited by this paper
• New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

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  2011influential reference
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  2011cited by this paper
• The Effects of Antidepressants on Mitochondrial Function in a Model Cell System and Isolated Mitochondria

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• Treatment with olanzapine, fluoxetine and olanzapine/fluoxetine alters citrate synthase activity in rat brain.

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  2010cited by this paper
• Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.

  2010cited by this paper
• New extension of the Mitchell Theory for oxidative phosphorylation in mitochondria of living organisms.

  2010influential reference
• Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase

  2010cited by this paper
• Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function.

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• Qo site of mitochondrial complex III is the source of increased superoxide after transient exposure to hydrogen peroxide.

  2010influential reference
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• Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis

  2010influential reference
• Glycolysis: a bioenergetic or a survival pathway?

  2010cited by this paper
• Multi-site control and regulation of mitochondrial energy production.

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• Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

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• Intracellular signalling pathways and mood disorders.

  2010cited by this paper
• The regulation and turnover of mitochondrial uncoupling proteins.

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• Oxidative stress in anxiety and comorbid disorders.

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• Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity.

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• Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers.

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• Effects of acute tryptophan depletion on memory, attention and executive functions: a systematic review.

  2009cited by this paper
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• Supramolecular organization of protein complexes in the mitochondrial inner membrane.

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• The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

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• Control of OXPHOS efficiency by complex I in brain mitochondria.

  2009influential reference
• Mitochondrial Dysfunction and Psychiatric Disorders

  2009cited by this paper
• Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.

  2009cited by this paper
• Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage.

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  2009cited by this paper
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• Modulation of calcium signalling by mitochondria.

  2009cited by this paper
• Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue.

  2009cited by this paper
• Mitochondrial transport and docking in axons.

  2009cited by this paper
• Neurobiological mechanisms in major depressive disorder

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• Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver.

  2008cited by this paper
• Depression, antidepressants, and peripheral blood components.

  2008cited by this paper
• Mitochondrial involvement in psychiatric disorders

  2008cited by this paper
• Nortriptyline Protects Mitochondria and Reduces Cerebral Ischemia/Hypoxia Injury

  2008cited by this paper
• Monoamine Oxidase Inhibitors: A Modern Guide to an Unrequited Class of Antidepressants

  2008cited by this paper
• Fatty acids as modulators of the cellular production of reactive oxygen species.

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• Novel Drugs and Therapeutic Targets for Severe Mood Disorders

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  2008cited by this paper
• The molecular neurobiology of depression

  2008cited by this paper
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

  2008cited by this paper
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• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

  2008cited by this paper
• Structure of Complex III with Bound Cytochrome c in Reduced State and Definition of a Minimal Core Interface for Electron Transfer*

  2008cited by this paper
• Mitochondria in neuroplasticity and neurological disorders.

  2008cited by this paper
• Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes

  2008cited by this paper
• Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder.

  2008influential reference
• The Effect of Antiepileptic Drugs on Mitochondrial Activity: A Pilot Study

  2008cited by this paper
• Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin.

  2008cited by this paper
• Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

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• Role of the mitochondrial membrane permeability transition in cell death

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• Bax affects production of reactive oxygen by the mitochondria of non-apoptotic neurons.

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• Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder.

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• Nortriptyline delays disease onset in models of chronic neurodegeneration

  2007influential reference
• Effects of lithium and valproate on hippocampus citrate synthase activity in an animal model of mania.

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• Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines

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• Lamotrigine inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death.

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• Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress

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• Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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• Nuclear-mitochondrial interaction.

  2007influential reference
• Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers

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• Uncoupling protein homologs may provide a link between mitochondria, metabolism and lifespan.

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• Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder.

  2006influential reference
• Mitochondrial uncoupling proteins: new insights from functional and proteomic studies.

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• Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transition.

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