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Cognition in Huntington's Disease

T. B. Wahlin,Gerard J. Byrne

Published 2012 in Unknown venue

ABSTRACT

Huntington's Disease (HD) is an autosomal dominant, neurodegenerative disease. It is characterized by severe involuntary motor dysfunction, so-called choreic movements, neurological and psychiatric symptoms and cognitive impairments that lead to dementia (Bates et al., 2002). Genetic markers for the gene that causes HD were identified in 1983, located on the short arm of chromosome four (Gusella et al., 1983). Ten years later in 1993 the gene was cloned (Huntington’s Disease Collaborative Research Group, 1993). HD was thus from the mid-1980s one of the first diseases where it was possible to predict whether an asymptomatic individual had inherited the genetic markers and would therefore become ill in the future. The clinical diagnosis of HD is based on the presence of motor symptoms and a positive mutation analysis, or on neurological and psychiatric symptoms in patients with a family history of HD.

PUBLICATION RECORD

  • Publication year

    2012

  • Venue

    Unknown venue

  • Publication date

    Unknown publication date

  • Fields of study

    Medicine, Psychology

  • Identifiers
    DOI 10.5772/30930
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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