The human placental lactogen genes: structure, function, evolution and transcriptional regulation.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Endocrine reviews

• Publication date

  1991-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/EDRV-12-4-316PMID 1760991
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sequence comparison of human pituitary growth hormone, human chorionic somatomammotropin, and ovine pituitary growth and lactogenic hormones.

  2009cited by this paper
• The Double Effect of Human Chorionic Somatomammotropin (HCS) and Pregnancy on Lipogenesis and on Lipolysis in the Isolated Rat Epididymal Fat Pad and Fat Pad Cells

  2009cited by this paper
• Nucleic Acids Research Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster

  2005cited by this paper
• Tissue-specific expression and thyroid hormone regulation of the endogenous placental growth hormone variant and chorionic somatomammotropin genes in a human choriocarcinoma cell line.

  1991cited by this paper
• DNA sequences involved in the transcriptional activation of a human placental lactogen gene.

  1990cited by this paper
• The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro.

  1990cited by this paper
• Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and trans-activate the human growth hormone gene

  1990cited by this paper
• Mechanism of transcriptional activation by Sp1: evidence for coactivators.

  1990cited by this paper
• Identification of placental human growth hormone as the growth hormone-V gene expression product.

  1990cited by this paper
• Human placental lactogen transcriptional enhancer. Tissue specificity and binding with specific proteins.

  1990cited by this paper
• Coding potential of transfected human placental lactogen genes.

  1990cited by this paper
• Purification of growth hormone-specific transcription factor GHF-1 containing homeobox.

  1989cited by this paper
• The human growth hormone locus: nucleotide sequence, biology, and evolution.

  1989cited by this paper
• Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human-growth-hormone gene.

  1989cited by this paper
• Sp1 activates transcription without enhancing DNA-binding activity of the TATA box factor

  1989cited by this paper
• Transcription factor Sp1 binds to and activates a human hsp70 gene promoter

  1989cited by this paper
• Pituitary-Specific Factor Binding to the Human Prolactin, Growth Hormone, and Placental Lactogen Genes

  1989cited by this paper
• Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence.

  1989cited by this paper
• Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat

  1989cited by this paper
• Placental lactogen and growth hormone receptors in human fetal tissues: relationship to fetal plasma human placental lactogen concentrations and fetal growth.

  1988cited by this paper
• A promoter of the rat insulin-like growth factor II gene consists of minimal control elements.

  1988cited by this paper
• The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence.

  1988cited by this paper
• Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.

  1988cited by this paper
• Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor.

  1988cited by this paper
• The human growth hormone gene contains both positive and negative control elements.

  1988cited by this paper
• A new natural hGH variant--17.5 kd--produced by alternative splicing. An additional consensus sequence which might play a role in branchpoint selection.

  1987cited by this paper
• Expression of the growth hormone variant gene in human placenta.

  1987cited by this paper
• One cell‐specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

  1987cited by this paper
• Regulated expression of chimaeric genes containing the 5'-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells.

  1987cited by this paper
• Transplantation of insulin-like growth factor-II-secreting tumors into nude rodents.

  1987cited by this paper
• Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.

  1987cited by this paper
• The Human Growth Hormone Gene Locus: Structure, Evolution, and Allelic Variations

  1987cited by this paper
• A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells.

  1987cited by this paper
• Tissue‐specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans‐acting factor.

  1987cited by this paper
• Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.

  1986cited by this paper
• The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.

  1986cited by this paper
• Isolation and identification of a cDNA clone of rat placental lactogen II.

  1986cited by this paper
• Promoter-specific activation of RNA polymerase II transcription by Sp1

  1986cited by this paper
• Purification of the insulin-like growth factor II (IGF-II) receptor from an IGF-II-producing cell line, and generation of an antibody which both immunoprecipitates and blocks the type 2 IGF receptor.

  1986cited by this paper
• Transcriptional enhancers play a major role in gene expression

  1986cited by this paper
• Thyroid hormone receptors bind to defined regions of the growth hormone and placental lactogen genes.

  1986cited by this paper
• Regulation of amino acid uptake and deoxyribonucleic acid synthesis in isolated human fetal fibroblasts and myoblasts: effect of human placental lactogen, somatomedin-C, multiplication-stimulating activity, and insulin.

  1986cited by this paper
• An effect of gene dosage on production of human chorionic somatomammotropin.

  1985cited by this paper
• Incorporation of [3H]thymidine by isolated fetal myoblasts and fibroblasts in response to human placental lactogen (HPL): Possible mediation of HPL action by release of immunoreactive SM‐C

  1985cited by this paper
• Multiple origins of transcription for the human placental lactogen genes.

  1984cited by this paper
• Relationship of maternal and fetal levels of human placental lactogen to the weight and sex of the fetus.

  1984cited by this paper
• Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.

  1984cited by this paper
• Plasma human chorionic somatomammotropin deficiency in a normal pregnancy is the consequence of low concentration of messenger RNA coding for human chorionic somatomammotropin.

  1983cited by this paper
• Structure and evolution of the growth hormone gene family.

  1983cited by this paper
• Two structurally different genes produce the same secreted human placental lactogen hormone.

  1983cited by this paper
• Immunologically undetectable human placental lactogen in a normal pregnancy.

  1983cited by this paper
• The human growth hormone gene family: structure and evolution of the chromosomal locus.

  1983cited by this paper
• Transcriptional products of the human placental lactogen gene.

  1982cited by this paper
• Human growth hormone: a multigene family.

  1982cited by this paper
• Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta

  1982cited by this paper
• Human growth hormone DNA sequence and mRNA structure: possible alternative splicing.

  1981cited by this paper
• A Gene Deletion is Responsible for Absence of Human Chorionic Somatomammotropin

  1981cited by this paper
• ISOLATED DEFECT IN HUMAN PLACENTAL LACTOGEN SYNTHESIS IN A NORMAL PREGNANCY

  1981cited by this paper
• The Human Growth Hormone Gene Family: Nucleotide Sequences Show Recent Divergence and Predict a New Polypeptide Hormone

  1981cited by this paper
• The 20,000-dalton variant of human growth hormone: location of the amino acid deletions.

  1980cited by this paper
• Interrelationships of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta 1-glycoprotein throughout normal human gestation.

  1980cited by this paper
• Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans.

  1980cited by this paper
• SIMILARITIES IN THE STRUCTURE AND FUNCTION OF BOTH THE MATURE FORMS AND BIOSYNTHETIC PRECURSORS OF PLACENTAL LACTOGEN AND GROWTH HORMONE *

  1980cited by this paper
• Absence of human placental lactogen in an otherwise uneventful pregnancy.

  1979cited by this paper
• Human growth hormone: complementary DNA cloning and expression in bacteria.

  1979cited by this paper
• Growth regulation of cultured human pituitary cells by steroidal and nonsteroidal compounds in defined medium.

  1979cited by this paper
• Successful transplantation of human benign breast tumors into the athymic nude mouse and demonstration of enhanced DNA synthesis by human placental lactogen.

  1978cited by this paper
• ADIPOSE TISSUE METABOLISM IN PREGNANCY: THE LIPOLYTIC EFFECT OF HUMAN PLACENTAL LACTOGEN

  1978cited by this paper
• Stimulation of DNA Synthesis by Human Placental Lactogen or Insulin in Organ Cultures of Benign Human Breast Tumors

  1977cited by this paper
• Stimulation of DNA synthesis by human placental lactogen or insulin in organ cultures of benign human breast tumors.

  1977cited by this paper
• Nucleotide sequence of part of the gene for human chorionic somatomammotropin: purification of DNA complementary to predominant mRNA species.

  1977cited by this paper
• Human pituitary prolactin (hPRL): the entire linear amino acid sequence.

  1977cited by this paper
• Heterogeneity of human growth hormone.

  1974cited by this paper
• Comparative studies on the metabolic effects of some parameters of carbohydrate and lipid metabolism after intravenous administration of human placental lactogen, human prolactin and growth hormone.

  1973cited by this paper
• Human chorionic somato-mammotrophin in serum and urine in various stages of pregnancy: its correlation with enzymes and oestrogens.

  1972cited by this paper
• CONCENTRATION OF CHORIONIC GONADOTROPHIN AND CHORIONIC SOMATOMAMMOTROPHIN IN MATERNAL SERUM, AMNIOTIC FLUID AND CORD BLOOD SERUM AT TERM

  1972cited by this paper
• Clonal lines of human choriocarcinoma cells in culture.

  1971cited by this paper
• Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication.

  1971cited by this paper
• Starvation in human pregnancy: hypoglycemia, hypoinsulinemia, and hyperketonemia.

  1971cited by this paper
• Plasma chorionic somatomammotropin levels during starvation in midpregnancy.

  1971cited by this paper
• Studies on the Metabolism of Human Placental Lactogen in Pregnancy

  1970cited by this paper
• Starvation in Human Pregnancy: Hypoglycemia, Hypoinsulinemia, and Hyperketonemia

  1970cited by this paper
• Time of appearance of human placental lactogen in the embryo.

  1970cited by this paper
• Relative Effects of Pregnancy, Human Placental Lactogen and Prednisolone on Carbohydrate Tolerance in Normal and Subclinical Diabetic Subjects

  1969cited by this paper
• Characterisation of antisera to a growth‐hormone‐like placental antigen (human placental lactogen): Immunofluorescence studies with these sera on normal and pathological syncytiotrophoblast

  1969cited by this paper
• CHORIONIC GROWTH HORMONE‐PROLACTIN (CGP): SECRETION, DISPOSITION, BIOLOGIC ACTIVITY IN MAN, AND POSTULATED FUNCTION AS THE “GROWTH HORMONE” OF THE SECOND HALF OF PREGNANCY *

  1968cited by this paper
• Human placental lactogen (HPL) and placental weight.

  1968cited by this paper
• Metabolic clearance rate and production rate of chorionic growth hormone-prolactin in late pregnancy.

  1968cited by this paper
• Metabolic effects of placental lactogen (HPL) in man.

  1968cited by this paper
• Human placental lactogen: studies of its acute metabolic effects and disposition in normal man.

  1967cited by this paper
• Dynamics of human placental lactogen.

  1966cited by this paper
• Serum chorionic "growth hormone-prolactin" and serum pituitary growth hormone in mother and fetus at term.

  1965cited by this paper
• PURIFICATION OF A PLACENTAL FACTOR WITH IMMUNOLOGICAL AND CHEMICAL SIMILARITY TO HUMAN GROWTH HORMONE.

  1965cited by this paper
• Human placental lactogen (HPL), a trophoblastic hormone synergizing with chorionic gonadotropin and potentiating the anabolic effects of pituitary growth hormone

  1964cited by this paper
• HUMAN PLACENTAL LACTOGEN (HPL), A TROPHOBLASTIC HORMONE SYNERGIZING WITH CHORIONIC GONASOTROPIN AND POTENTIATING THE ANABOLIC EFFECTS OF PITUITARY GROWTH HORMONE.

  1964cited by this paper
• Localization of Anti-human Growth Hormone Serum within the Human Placenta : Evidence for a Human Chorionic ‘Growth Hormone-prolactin’

  1963cited by this paper
• THE ORIGIN AND FUNCTION OF HUMAN SYNCYTIOTROPHOBLASTIC GIANT CELLS.

  1963cited by this paper
• Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone.

  1962cited by this paper

• Safety and dose‐finding trial of tadalafil administered for fetus in labor: A phase I clinical study

  2024cites this paper
• The Neurobiology of Parenting and Infant-Evoked Aggression.

  2024cites this paper
• A case of multiple soft fibromas complicated with pityriasis versicolor during pregnancy: A case report

  2024cites this paper
• Exploring maternal-fetal interface with in vitro placental and trophoblastic models

  2023cites this paper
• Effect of high fat diet on maternal behavior, brain‐derived neurotrophic factor and neural stem cell proliferation in mice expressing human placental lactogen during pregnancy

  2023cites this paper
• Screening for late‐onset gestational diabetes: Are there any clinical benefits?

  2022cites this paper
• Prenatal health behaviours as predictors of human placental lactogen levels

  2022cites this paper
• Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex

  2021influential citation
• Placental growth factor level is correlated with intrapartum fetal heart rate findings

  2021cites this paper
• Placensin is a glucogenic hormone secreted by human placenta

  2020cites this paper
• Placental Lactogen as a Marker of Maternal Obesity, Diabetes, and Fetal Growth Abnormalities: Current Knowledge and Clinical Perspectives

  2020cites this paper
• Pathogenesis of Gestational Diabetes Mellitus

  2019cites this paper
• Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia

  2018cites this paper
• Chromosomal architecture and placental expression of the human growth hormone gene family are targeted by pre-pregnancy maternal obesity.

  2018cites this paper
• Chorionic somatomammotropin impacts early fetal growth and placental gene expression.

  2018cites this paper
• Chronic limb-threatening ischemia could benefit from growth hormone therapy for wound healing and limb salvage

  2017cites this paper
• Human placental growth hormone in normal and abnormal fetal growth

  2017cites this paper
• Development of ovine chorionic somatomammotropin hormone-deficient pregnancies.

  2016cites this paper
• Structure and evolution of the gorilla and orangutan growth hormone loci

  2016cites this paper
• Placental Endocrine Function and Hormone Action

  2015cites this paper
• Expression of Placental Members of the Human Growth Hormone Gene Family Is Increased in Response to Sequential Inhibition of DNA Methylation and Histone Deacetylation

  2015cites this paper
• The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings

  2015cites this paper
• Screening of high toxic Metarhizium strain against Plutella xylostella and its marking with green fluorescent protein

  2014cites this paper
• Tissue specific CTCF occupancy and boundary function at the human growth hormone locus

  2014cites this paper
• Prolactine placentaire et anomalies de croissance au cours du diabète maternel

  2014cites this paper
• Pregnancy: Placental Lactogen (CSH)

  2014cites this paper
• Screening of high toxic Metarhizium strain against Plutella xylostella and its marking with green fluorescent protein

  2014cites this paper
• Delivery of AP-2α siRNA into cultured bovine trophoblast cells by electroporation repressed key placenta-specific gene expression.

  2012cites this paper
• "Nicotiana tabacum" L. cv Xanthi como sistema heterólogo para la producción de lactógeno placentario humano (hPL)

  2012influential citation
• Clinical use of placental hormones in pregnancymanagement

  2012cites this paper
• Hormones and Reproductive Cycles in Primates

  2011cites this paper
• Prolactin and Lactation as Modifiers of Diabetes Risk in Gestational Diabetes

  2011cites this paper
• Tobacco as biofactory for biologically active hPL production: a human hormone with potential applications in type-1 diabetes

  2011cites this paper
• CHAPTER 21 – Endocrine Changes in Pregnancy

  2011cites this paper
• Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability

  2010cites this paper
• Chapitre 1 – La placentation humaine

  2010cites this paper
• In vitro assessment of probiotic properties of Bacillus isolated from naturally fermented congee from Inner Mongolia of China

  2010cites this paper
• hGH-V gene expression and promoter activity under glucose and 5-azacytidine (5azaC) effects.

  2010cites this paper
• Growth hormone-related genes from baboon (Papio hamadryas): Characterization, placental expression and evolutionary aspects.

  2010cites this paper
• of RNA-Binding CCCH Tandem Zinc Finger Proteins

  2009cites this paper
• Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities.

  2009cites this paper
• Reassessment of the role of human placental lactogen in physiological non-pregnant and pathological conditions.

  2009cites this paper
• Running title: Serum biomarkers of tubal ectopic pregnancy

  2009cites this paper
• Peptide hormone regulation of angiogenesis.

  2009cites this paper
• Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus.

  2009cites this paper
• ZFP36L3: A unique member of the tristetraprolin family of RNA-binding CCCH tandem zinc finger proteins

  2009cites this paper
• Comparative aspects of placental lactogens: structure and function.

  2009cites this paper
• Interaction of lysyl oxidase with the hormone placental lactogen and its effecton mammary epithelial cell proliferation and migration

  2008cites this paper
• Local production of the gonadotropic hormones in the rat ovary.

  2008cites this paper
• Lysyl Oxidase Interacts with Hormone Placental Lactogen and Synergistically Promotes Breast Epithelial Cell Proliferation and Migration*

  2007cites this paper
• Neuroendocrine control of growth hormone in fish.

  2007cites this paper
• Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor

  2007cites this paper
• The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression.

  2006cites this paper
• Growth hormone locus expands and diverges after the separation of New and Old World Monkeys.

  2006cites this paper
• Expression and purification of human placenta lactogen in Escherichia coli.

  2006cites this paper
• Human Placental Lactogen Decreases Regional Blood Flow in Anesthetized Pigs

  2006cites this paper
• Proteomic Analysis on the Alteration of Protein Expression in the Placental Villous Tissue of Early Pregnancy Loss

  2006cites this paper
• The Endocrine Function of the Placenta: Interactions Between Trophic Peptides and Hormones

  2006cites this paper
• The role of nitric oxide in the peripheral vasoconstriction caused by human placental lactogen in anaesthetized pigs

  2006cites this paper
• CHAPTER 53 – Placental Endocrine Function

  2006cites this paper
• The correlation between sampling site and gene expression in the term human placenta.

  2005cites this paper
• Discovery of protein-protein interactions of the lysyl oxidase enzyme : implications for cardiovascular disease, cancer and fibrosis

  2005cites this paper
• Maternal cognitive functioning in pregnancy and its association with gestation, endocrine factors and fetal sex: A longitudinal study in women from early pregnancy to the postpartum period

  2005cites this paper
• Hormonal aspects in the causation of human breast cancer: epidemiological hypotheses reviewed, with special reference to nutritional status and first pregnancy.

  2005cites this paper
• Microarray-based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses.

  2005cites this paper
• Nutritional assessment of somatolactin function in gilthead sea bream (Sparus aurata): concurrent changes in somatotropic axis and pancreatic hormones.

  2004cites this paper
• Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein

  2004influential citation
• Transcriptional control of the human pregnancy-specific glycoprotein 5 gene is dependent on two GT-boxes recognized by the ubiquitous specificity protein 1 (Sp1) transcription factor.

  2004cites this paper
• Long-term, but not short-term, treatment with somatotropin during pregnancy in underfed pigs increases the body size of progeny at birth.

  2004cites this paper
• Puralpha, a single-stranded deoxyribonucleic acid binding protein, augments placental lactogen gene transcription.

  2004cites this paper
• Crecimiento intrauterino: factores reguladores. Retraso de crecimiento intrauterino

  2003cites this paper
• Functional differentiation of the placental syncytiotrophoblast: Effect of estrogen on chorionic somatomammotropin expression during early primate pregnancy.

  2003cites this paper
• Placental Gene Expression

  2003cites this paper
• Predictive value of hormone measurements in maternal and fetal complications of pregnancy.

  2002cites this paper
• Maternal Serum Levels of Human Chorionic Somatotropin Correlates with Transferrin and Erythropoietin in Pregnancy

  2002cites this paper
• Hormones placentaires humaines

  2002cites this paper
• Overview of Fish Growth Hormone Family. New Insights in Genomic Organization and Heterogeneity of Growth Hormone Receptors

  2002cites this paper
• Growth Hormone and Prolactin—Molecular and Functional Evolution

  2002cites this paper
• GH as a co-gonadotropin: the relevance of correlative changes in GH secretion and reproductive state.

  2002influential citation
• Frequent co-amplification of two different regions on 17q in aneuploid breast carcinomas.

  2001cites this paper
• Impact of Pregnancy On Normal Pituitary Function

  2001cites this paper
• The Roles of Growth Hormone, Prolactin and Placental Lactogen In Maternal Metabolism and Fetal Development

  2001cites this paper
• The localization of dopamine D2 receptor mRNA in the human placenta and the anti-angiogenic effect of apomorphine in the chorioallantoic membrane.

  2001cites this paper
• Transcriptional regulation in the placenta during normal and compromised fetal growth.

  2001cites this paper
• Factors Influencing Fetal Growth

  2001cites this paper
• Structure and transcriptional regulation of the ovine placental lactogen gene.

  2001cites this paper
• The Roles of Placental Growth Hormone and Placental Lactogen in the Regulation of Human Fetal Growth and Development

  2000cites this paper
• Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region

  2000cites this paper
• The Human Growth Hormone Gene Cluster Locus Control Region Supports Position-independent Pituitary- and Placenta-specific Expression in the Transgenic Mouse*

  2000cites this paper
• Activator protein-2 regulates human placental lactogen gene expression.

  2000cites this paper
• Transcription of genes encoding pregnancy-specific glycoproteins is regulated by negative promoter-selective elements.

  2000cites this paper
• Promoter shuffling has occurred during the evolution of the vertebrate growth hormone gene.

  2000cites this paper
• N-Glycosylated Variants of Growth Hormone in Human Pituitary Extracts

  2000cites this paper
• A panel of monoclonal antibodies to ovine placental lactogen.

  2000cites this paper
• Mitogen-activated protein kinase activates human placental lactogen-B enhancer by an NF-IL6-dependent pathway

  2000cites this paper
• Placental Trophoblast Cells

  2000cites this paper
• The Roles of Growth Hormone, Prolactin, and Placental Lactogen in Human Fetal Development

  1999cites this paper
• The testis-specific expression pattern of the growth hormone/placental lactogen (GH/PL) gene cluster changes with malignancy.

  1999cites this paper
• Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis.

  1999cites this paper
• Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy

  1999cites this paper