gamma-H2AX as protein biomarker for radiation exposure.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Annali dell'Istituto Superiore di Sanità

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Environmental Science

• Identifiers
  PMID 19861731
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions].

  2009cited by this paper
• DNA double-strand breaks after percutaneous transluminal angioplasty.

  2008cited by this paper
• γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

  2008cited by this paper
• Quantitative assessment of diagnostic radiation doses in adult blunt trauma patients.

  2008cited by this paper
• Cytotoxicity of cigarette smoke condensate is not due to DNA double strand breaks: Comparative studies using radiosensitive mutant and wild-type CHO cells

  2007cited by this paper
• gamma-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: Dependence on the dose-distribution, irradiated site and time from start of treatment

  2007cited by this paper
• Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure.

  2007cited by this paper
• An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans

  2007cited by this paper
• Gamma-H2AX foci counting: image processing and control software for high-content screening

  2007cited by this paper
• DNA double-strand break repair: all's well that ends well.

  2006cited by this paper
• CellProfiler: image analysis software for identifying and quantifying cell phenotypes

  2006cited by this paper
• Imaging Features that Discriminate between Foci Induced by High- and Low-LET Radiation in Human Fibroblasts

  2006cited by this paper
• Computational Methods for Analysis of Foci: Validation for Radiation-Induced γ-H2AX Foci in Human Cells

  2006cited by this paper
• Interplay between human DNA repair proteins at a unique double‐strand break in vivo

  2006cited by this paper
• Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA‐PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

  2005cited by this paper
• The histone code at DNA breaks: a guide to repair?

  2005cited by this paper
• Early-response biological dosimetry--recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism.

  2005cited by this paper
• DNA repair: the importance of phosphorylating histone H2AX.

  2005cited by this paper
• Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?

  2005cited by this paper
• Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis

  2005cited by this paper
• In vivo formation and repair of DNA double-strand breaks after computed tomography examinations.

  2005cited by this paper
• Does γH2AX foci formation depend on the presence of DNA double strand breaks

  2005cited by this paper
• HIF-1: A Target For Cancer, Ischemia and Inflammation—Too Good to be True?

  2004cited by this paper
• A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity

  2004cited by this paper
• A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

  2004cited by this paper
• H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity

  2004cited by this paper
• DNA double strand break quantification in skin biopsies.

  2004cited by this paper
• Induction of H2AX Phosphorylation in Pulmonary Cells by Tobacco Smoke: A New Assay for Carcinogens

  2004cited by this paper
• Different Means to an End: DNA Double-Strand Break Repair

  2004cited by this paper
• No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells.

  2004cited by this paper
• Comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single‐cell gel electrophoresis

  2004cited by this paper
• H2AX: the histone guardian of the genome.

  2004cited by this paper
• ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

  2004cited by this paper
• Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy*

  2004cited by this paper
• Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

  2003cited by this paper
• Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes*

  2003cited by this paper
• Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

  2003cited by this paper
• Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase.

  2003cited by this paper
• Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

  2003cited by this paper
• Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody.

  2002cited by this paper
• Genomic Instability in Mice Lacking Histone H2AX

  2002cited by this paper
• DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

  2002cited by this paper
• Quantitative Detection of 125IdU-Induced DNA Double-Strand Breaks with γ-H2AX Antibody

  2002cited by this paper
• Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

  1999cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper

• Chromatin Nano-Organization in Peripheral Blood Mononuclear Cells After In-Solution Irradiation with the Beta-Emitter Lu-177

  2026cites this paper
• A Procedure to Estimate Dose and Time of Exposure to Ionizing Radiation from the γ-H2AX Assay

  2025cites this paper
• Correlation between DNA double strand breaks and cell death in peripheral blood lymphocytes from breast cancer patients

  2025cites this paper
• Activities of ISO Working Group 18: Biological and Physical Retrospective Dosimetry

  2025cites this paper
• Radiation-induced lymphopenia: In-silico replications of preclinical studies suggest importance of dose to lymphoid organs.

  2025cites this paper
• Evaluation of predictive biomarkers for late radiation toxicity in breast cancer patients

  2025cites this paper
• Single-Cell Sequencing: An Emerging Tool for Biomarker Development in Nuclear Emergencies and Radiation Oncology

  2025cites this paper
• Advancing Genotoxicity Assessment by Building a Global AOP Network

  2025cites this paper
• Comparison of radiobiological effects induced by radiolabeled antibodies in human cancer cells and fungal cells

  2025cites this paper
• Heterogeneous Formation of DNA Double-Strand Breaks and Cell-Free DNA in Leukemia T-Cell Line and Human Peripheral Blood Mononuclear Cells in Response to Topoisomerase II Inhibitors

  2024cites this paper
• Induction of Chromosomal Aberrations after Exposure to the Auger Electron Emitter Iodine-125, the β–-emitter Tritium and Cesium-137 γ rays

  2024cites this paper
• The Use of Survival Dose-Rate Dependencies as Theoretical Discrimination Criteria for In-Silico Dynamic Radiobiological Models

  2024cites this paper
• The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation

  2024cites this paper
• Chronic Low-Dose-Rate Radiation-Induced Persistent DNA Damage and miRNA/mRNA Expression Changes in Mouse Hippocampus and Blood

  2024cites this paper
• In vitro validation of helium ion irradiations as a function of linear energy transfer in radioresistant human malignant cells

  2024cites this paper
• Development of high-throughput systems for biodosimetry

  2023cites this paper
• Effect of curcumin on γ–ray-induced cell response

  2023cites this paper
• Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts

  2023cites this paper
• Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy

  2023cites this paper
• Assessment of radiation doses and DNA damage in pediatric patients undergoing interventional procedures for vascular anomalies.

  2023cites this paper
• Wie kann die biologische Dosimetrie in Fällen unklarer Strahlenbelastung helfen?

  2023cites this paper
• High-Throughput γ-H2AX Assay Using Imaging Flow Cytometry.

  2023cites this paper
• Ex-vivo dose response characterization of the recently identified EDA2R gene after low level radiation exposures and comparison with FDXR gene expression and the γH2AX focus assay

  2023cites this paper
• A stochastic model of blood flow to calculate blood dose during radiotherapy

  2023cites this paper
• The Imaging Flow Cytometry-Based Cytokinesis-Block MicroNucleus (CBMN) Assay.

  2023cites this paper
• Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields

  2023cites this paper
• Bystander Response Following High-Dose X-irradiation; Time-dependent Nature of GammaH2AX Foci and Cell Death Consequences

  2023cites this paper
• RENEB Inter-Laboratory Comparison 2021: The Gamma-H2AX Foci Assay

  2023cites this paper
• Differential Radiosensitizing Effect of 50 nm Gold Nanoparticles in Two Cancer Cell Lines

  2022cites this paper
• Improving radiation dose estimation using the gamma-H2AX biomarker

  2022cites this paper
• Computational modelling of γ-H2AX foci formation in human cells induced by alpha particle exposure

  2022cites this paper
• Radiosensitivity in patients affected by ARPC1B deficiency: a new disease trait?

  2022cites this paper
• STUDY ON RADIOPROTECTION EFFECT FOR HUMAN LYMPHOCYTES AND FIBROBLASTS OF RESVERATROL-ENCAPSULATED LIPOSOME HIỆU QUẢ BẢO VỆ BỨC XẠ CHO TẾ BÀO LYMPHO NGƯỜI VÀ NGUYÊN BÀO SỢI NGƯỜI CỦA LIPOSOME ĐÓNG GÓI RESVERATROL

  2022cites this paper
• -Omics potential of in vitro skin models for radiation exposure

  2022cites this paper
• High-throughput screening strategies for space-based radiation countermeasure discovery.

  2022cites this paper
• Characterization of γ-H2AX foci formation under alpha particle and X-ray exposures for dose estimation

  2022cites this paper
• A deep learning model (FociRad) for automated detection of γ-H2AX foci and radiation dose estimation

  2022cites this paper
• Detection of Radiation-Induced DNA Damage in Breast Cancer Patients by Using Gamma H2AX Biomarker: A Possible Correlation with Their Body Mass Index

  2022cites this paper
• Radiation dose estimation with time-since-exposure uncertainty using the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document

  2022influential citation
• In vitro Assessment of the DNA Damage Response in Dental Mesenchymal Stromal Cells Following Low Dose X-ray Exposure

  2021cites this paper
• Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair.

  2021cites this paper
• Biodosimetry in interventional radiology: cutaneous-based immunoassay for anticipating risks of dermatitis

  2021influential citation
• Correlation between γ -H2AX, micronucleus and annual occupational dose in medical radiation workers

  2021cites this paper
• Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy

  2021cites this paper
• Potential Use of Biomarker γ-H2AX on Peripheral Blood Patient Who Underwent Radioiodine Ablation Treatment in Indonesia

  2021cites this paper
• The effect of data aggregation on dispersion estimates in count data models

  2021cites this paper
• Potential increase in radiation‐induced DNA double‐strand breaks with higher doses of iodine contrast during coronary CT angiography

  2021cites this paper
• DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time

  2021cites this paper
• Establishment and multiparametric-cytogenetic validation of 60Co-gamma-ray induced, phospho-gamma-H2AX calibration curve for rapid biodosimetry and triage management during radiological emergencies.

  2021cites this paper
• Production of Pyracantha Polysaccharide-Iron(III) Complex and Its Biologic Activity

  2021cites this paper
• Comparative analysis of physical doses and biomarker changes in subjects underwent Computed Tomography, Positron Emission Tomography-Computed Tomography, and interventional procedures.

  2021cites this paper
• Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation

  2021cites this paper
• The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology

  2020cites this paper
• Evaluation of Capability and Relationship of Different Radiobiological Endpoints for Radiosensitivity Prediction in Human Tumor Cell Lines Compared with Clonogenic Survival

  2020influential citation
• Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model

  2020cites this paper
• Evaluating Individual Radiosensitivity for the Prediction of Acute Toxicities of Chemoradiotherapy in Esophageal Cancer Patients

  2020cites this paper
• TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double‐strand breaks in vertebrate cells

  2020cites this paper
• Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas

  2020cites this paper
• RadAtlas 1.0: a knowledgebase focusing on radiation-associated genes

  2020cites this paper
• Applying Tissue Slice Culture in Cancer Research—Insights from Preclinical Proton Radiotherapy

  2020cites this paper
• DeepFoci: Deep learning-based algorithm for fast automatic analysis of DNA double-strand break ionizing radiation-induced foci

  2020cites this paper
• Radiation Biomarkers in Large Scale Human Health Effects Studies

  2020cites this paper
• Enhanced response of radioresistant carcinoma cell line to heterogeneous dose distribution of grid; the role of high-dose bystander effect

  2020cites this paper
• Radiation-Induced Phosphorylation of Serine 360 of SMC1 in Human Peripheral Blood Mononuclear Cells

  2019cites this paper
• Polysaccharides from Pyracantha fortuneana and its biological activity.

  2019cites this paper
• Development of a high-throughput γ-H2AX assay based on imaging flow cytometry

  2019cites this paper
• DNA damage response in peripheral mouse blood leukocytes in vivo after variable, low-dose rate exposure

  2019cites this paper
• 18F-FDG PET/CT scanning: Biological effects on patients: Entrance surface dose, DNA damage, and chromosome aberrations in lymphocytes.

  2019cites this paper
• The influence of the iodinate contrast medium during CT: Single center experience - Development of two competitive in-house methods for automated quantification of DDSB

  2019cites this paper
• Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment.

  2019cites this paper
• Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms

  2019cites this paper
• Assessment of Radio-Induced Damage in Endothelial Cells Irradiated with 40 kVp, 220 kVp, and 4 MV X-rays by Means of Micro and Nanodosimetric Calculations

  2019influential citation
• Iodine Dose of Administered Contrast Media Affects the Level of Radiation-Induced DNA Damage During Cardiac CT Scans.

  2019cites this paper
• Effect of dose and dose rate on temporal γ-H2AX kinetics in mouse blood and spleen mononuclear cells in vivo following Cesium-137 administration

  2019cites this paper
• Residential exposure to radon and levels of histone γH2AX and DNA damage in peripheral blood lymphocytes of residents of Kowary city regions (Poland).

  2019cites this paper
• Cell Type–Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry

  2018cites this paper
• Nanoscopic Analysis of Chromatin Organization during DNA Double-Strand Repair using STED Microscopy

  2018cites this paper
• Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis

  2018cites this paper
• Cytogenetic and Molecular Damages in Blood Lymphocyte ofInhabitants Living in High Level Natural Radiation Area (HLNRA) of Botteng Village, Mamuju, West Sulawesi, Indonesia

  2018cites this paper
• DNA double strand breaks induced by low dose mammography X-rays in breast tissue: A pilot study.

  2018cites this paper
• Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response

  2018cites this paper
• SMC1A is associated with radioresistance in prostate cancer and acts by regulating epithelial‐mesenchymal transition and cancer stem‐like properties

  2018cites this paper
• DNA damage assessment and potential applications in laboratory diagnostics and precision medicine

  2018cites this paper
• 2 Suitability of the-H 2 AX Assay for Human Radiation Biodosimetry

  2018cites this paper
• -H2AX Assay for Human Radiation Biodosimetry

  2018cites this paper
• A statistical framework for radiation dose estimation with uncertainty quantification from the γ-H2AX assay

  2018influential citation
• Radiation resistance of normal human astrocytes: the role of non-homologous end joining DNA repair activity

  2018cites this paper
• A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage.

  2018cites this paper
• DosiKit, a New Immunoassay for Fast Radiation Biodosimetry of Hair and Blood Samples

  2018cites this paper
• In Vitro Cell Irradiation with Low Energy Protons. DNA Double Strand Break Induction and Repair Kinetics in Human Glioblastoma Cells.

  2018cites this paper
• Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

  2018cites this paper
• The iodine dose of administered contrast media determines the level of radiation-induced DNA damage during cardiac CT scans

  2018cites this paper
• UNCERTAINTY ON RADIATION DOSES ESTIMATED BY BIOLOGICAL AND RETROSPECTIVE PHYSICAL METHODS

  2018cites this paper
• Removal of scatter radiation in paediatric cardiac catheterisation: a randomised controlled clinical trial

  2017cites this paper
• The Application of Imaging Flow Cytometry to High-Throughput Biodosimetry

  2017cites this paper
• Inorganic polyphosphate enhances radio-sensitivity in a human non–small cell lung cancer cell line, H1299

  2017cites this paper
• DosiKit, a New Portable Immunoassay for Fast External Irradiation Biodosimetry

  2017cites this paper
• Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence of Hematopoietic Cell via Protecting Bone Marrow Stromal Cells from Oxidative Injuries Caused by 5-Fluorouracil

  2017cites this paper
• Biological characterization of a novel in vitro cell irradiator

  2017cites this paper
• Chronic Exposure to the Fusarium Mycotoxin Deoxynivalenol: Impact on Performance, Immune Organ, and Intestinal Integrity of Slow-Growing Chickens

  2017cites this paper