Synaptic correlates of benzodiazepine tolerance.

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Molecular Psychiatry

• Publication date

  2026-02-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/s41380-026-03512-8PMID 41748921
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy.

  2025cited by this paper
• Discovery of Novel Antiepileptic Agents Targeting the α1β2γ2 GABAA Receptor.

  2025cited by this paper
• Risk of dementia following gabapentin prescription in chronic low back pain patients

  2025cited by this paper
• Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity.

  2024cited by this paper
• Local and global effects of sedation in resting-state fMRI: a randomized, placebo-controlled comparison between etifoxine and alprazolam

  2024cited by this paper
• Nonsedating anxiolytics.

  2024cited by this paper
• A comprehensive review of the typical and atypical side effects of gabapentin

  2024cited by this paper
• Benzodiazepine use for anxiety disorders is associated with increased long-term risk of mood and substance use disorders: A large-scale retrospective cohort study

  2024cited by this paper
• Clinical and neuroimaging predictors of benzodiazepine response in catatonia: A machine learning approach.

  2024cited by this paper
• Chronic use of benzodiazepines: The problem that persists

  2023cited by this paper
• Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

  2023cited by this paper
• Modulators of GABA_A receptor-mediated inhibition in the treatment of neuropsychiatric disorders: past, present, and future

  2023cited by this paper
• Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain

  2023cited by this paper
• Translocator protein in the rise and fall of central nervous system neurons

  2023cited by this paper
• The association between Gabapentin or Pregabalin use and the risk of dementia: an analysis of the National Health Insurance Research Database in Taiwan

  2023cited by this paper
• GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

  2023cited by this paper
• Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

  2022cited by this paper
• Complex Persistent Benzodiazepine Dependence-When Benzodiazepine Deprescribing Goes Awry.

  2022cited by this paper
• Why won’t it stop? The dynamics of benzodiazepine resistance in status epilepticus

  2022cited by this paper
• Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain

  2022cited by this paper
• Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy

  2022cited by this paper
• Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

  2022cited by this paper
• Trends in Nonfatal and Fatal Overdoses Involving Benzodiazepines — 38 States and the District of Columbia, 2019–2020

  2021cited by this paper
• Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses

  2021cited by this paper
• ‘I just thought that it was such an impossible thing’: A qualitative study of barriers and facilitators to discontinuing long‐term use of benzodiazepine receptor agonists using the Theoretical Domains Framework

  2021cited by this paper
• Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale

  2021cited by this paper
• Global transgenic upregulation of KCC2 confers enhanced diazepam efficacy in treating sustained seizures

  2021cited by this paper
• Electrophysiology of ionotropic GABA receptors

  2021cited by this paper
• Continuous Infusion of Flumazenil in the Management of Benzodiazepines Detoxification

  2021cited by this paper
• Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology

  2021cited by this paper
• Pharmacological uses of flumazenil in benzodiazepine use disorders: a systematic review of limited data

  2021cited by this paper
• BENZODIAZEPINE EXPOSURE INDUCES TRANSCRIPTIONAL DOWN-REGULATION OF GABAA RECEPTOR α1 SUBUNIT GENE VIA L-TYPE VOLTAGE-GATED CALCIUM CHANNEL ACTIVATION IN RAT CEREBROCORTICAL NEURONS.

  2020cited by this paper
• Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions

  2020cited by this paper
• Regulation of GABAARs by Transmembrane Accessory Proteins.

  2020cited by this paper
• Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons

  2020cited by this paper
• Nonmedical use of benzodiazepines and Z‐drugs in the UK

  2020cited by this paper
• GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation.

  2020cited by this paper
• Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking

  2019cited by this paper
• Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

  2019cited by this paper
• Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

  2019cited by this paper
• A half century of γ-aminobutyric acid

  2019cited by this paper
• Positron emission tomography imaging of the γ-aminobutyric acid system.

  2019cited by this paper
• GABAA receptor signalling mechanisms revealed by structural pharmacology

  2019cited by this paper
• Subtype selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update.

  2019cited by this paper
• A structural perspective on GABAA receptor pharmacology.

  2019cited by this paper
• Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors

  2018cited by this paper
• International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans

  2018cited by this paper
• Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors

  2018cited by this paper
• Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐GABAA receptor subunit expression

  2018cited by this paper
• Treatment of Generalized Anxiety Disorder with Gabapentin

  2017cited by this paper
• Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

  2017cited by this paper
• Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis

  2017cited by this paper
• Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo.

  2016cited by this paper
• Chronic benzodiazepine treatment decreases spine density in cortical pyramidal neurons.

  2016cited by this paper
• Activation-induced regulation of GABAA receptors: Is there a link with the molecular basis of benzodiazepine tolerance?

  2016cited by this paper
• Neurodevelopment, GABA System Dysfunction, and Schizophrenia

  2015cited by this paper
• Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

  2015cited by this paper
• Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses.

  2015cited by this paper
• GABA receptors in brain development, function, and injury

  2015cited by this paper
• Dopamine D3 receptor-dependent changes in alpha6 GABAA subunit expression in striatum modulate anxiety-like behaviour: Responsiveness and tolerance to diazepam.

  2015cited by this paper
• Temporal profile of brain response to alprazolam in patients with generalized anxiety disorder.

  2015cited by this paper
• Benzodiazepine-dependent stabilization of GABA(A) receptors at synapses.

  2014cited by this paper
• GABA‐induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor

  2014cited by this paper
• Benzodiazepine dependence and its treatment with low dose flumazenil

  2014cited by this paper
• Enhanced lateral inhibition in the barrel cortex by deletion of phospholipase C-related catalytically inactive protein-1/2 in mice

  2014cited by this paper
• GABA actions and ionic plasticity in epilepsy.

  2014cited by this paper
• Disrupted Cl− homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

  2013cited by this paper
• Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation.

  2013cited by this paper
• Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial

  2013cited by this paper
• Molecular and functional heterogeneity of GABAergic synapses

  2012cited by this paper
• Focal nonconvulsive seizures during detoxification for benzodiazepine abuse.

  2012cited by this paper
• Benzodiazepine treatment induces subtype-specific changes in GABAA receptor trafficking and decreases synaptic inhibition

  2012cited by this paper
• A novel GABAA receptor pharmacology: drugs interacting with the α+β‐ interface

  2012cited by this paper
• The dynamic modulation of GABA(A) receptor trafficking and its role in regulating the plasticity of inhibitory synapses.

  2011cited by this paper
• Hooked on benzodiazepines: GABAA receptor subtypes and addiction.

  2011cited by this paper
• Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

  2010cited by this paper
• Neural bases for addictive properties of benzodiazepines

  2010cited by this paper
• Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty.

  2010cited by this paper
• Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents

  2010cited by this paper
• Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma.

  2009cited by this paper
• Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition

  2009cited by this paper
• Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

  2009cited by this paper
• Reduced benzodiazepine tolerance, but increased flumazenil-precipitated withdrawal in AMPA-receptor GluR-A subunit-deficient mice.

  2009cited by this paper
• Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.

  2008cited by this paper
• KCC2-Deficient Mice Show Reduced Sensitivity to Diazepam, but Normal Alcohol-Induced Motor Impairment, Gaboxadol-Induced Sedation, and Neurosteroid-Induced Hypnosis

  2007cited by this paper
• Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

  2005cited by this paper
• Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.

  2005cited by this paper
• Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study.

  2005cited by this paper
• Cognitive Effects of Long-Term Benzodiazepine Use

  2004cited by this paper
• Pentobarbital Differentially Modulates α1β3δ and α1β3γ2L GABAA Receptor Currents

  2004cited by this paper
• Modelling acute tolerance to the EEG effect of two benzodiazepines.

  2003cited by this paper
• Trace fear conditioning involves hippocampal α5 GABAA receptors

  2002cited by this paper
• Role of the PLC‐related, catalytically inactive protein p130 in GABAA receptor function

  2002cited by this paper
• Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal.

  2002cited by this paper
• Molecular and neuronal substrate for the selective attenuation of anxiety.

  2000cited by this paper
• Tolerance and rebound insomnia with rapidly eliminated hypnotics: a meta-analysis of sleep laboratory studies.

  1999cited by this paper
• Decreased GABA Enhancement of Benzodiazepine Binding After a Single Dose of Diazepam

  1999cited by this paper
• Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

  1999cited by this paper
• Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.

  1998cited by this paper
• Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study.

  1998cited by this paper

• No citing papers are available for this paper.