Boosting Fosfomycin Efficacy Against Methicillin-Resistant Staphylococcus aureus Infections by Targeting Pyrimidine Metabolism

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Engineering

• Publication date

  2026-03-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.eng.2026.01.025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Tackling Antibiotic Resistance: Exploring 5-Fluorouracil as a Promising Antimicrobial Strategy for the Treatment of Streptococcus suis Infection

  2024cited by this paper
• Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3.

  2024cited by this paper
• Anti-cancer agent 5-fluorouracil reverses meropenem resistance in carbapenem-resistant Gram-negative pathogens.

  2024cited by this paper
• Two co-dependent routes lead to high-level MRSA

  2024cited by this paper
• Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide

  2023cited by this paper
• Fosfomycin Enhances the Inhibition Ability of Linezolid Against Biofilms of Vancomycin-Resistant Enterococcus faecium in vitro

  2023cited by this paper
• Systematic analysis of drug combinations against Gram-positive bacteria

  2023cited by this paper
• Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance

  2023cited by this paper
• Structural‐Activity Relationship‐Inspired the Discovery of Saturated Fatty Acids as Novel Colistin Enhancers

  2023cited by this paper
• In Vitro and In Vivo Synergism of Fosfomycin in Combination with Meropenem or Polymyxin B against KPC-2-Producing Klebsiella pneumoniae Clinical Isolates

  2023cited by this paper
• Crizotinib Shows Antibacterial Activity against Gram-Positive Bacteria by Reducing ATP Production and Targeting the CTP Synthase PyrG

  2022cited by this paper
• Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.

  2022cited by this paper
• Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review.

  2022cited by this paper
• Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

  2021cited by this paper
• Diclofenac Resensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactams and Prevents Implant Infections

  2021cited by this paper
• Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing

  2021cited by this paper
• Melatonin prevents conjugative transfer of plasmid-mediated antibiotic resistance genes by disrupting proton motive force.

  2021cited by this paper
• Antibacterial and antibiofilm effects of flufenamic acid against methicillin-resistant Staphylococcus aureus.

  2020cited by this paper
• Pyrimidine analogs as a new class of Gram-positive antibiotics, mainly targeting thymineless-death related proteins.

  2020cited by this paper
• A Deep Learning Approach to Antibiotic Discovery.

  2020cited by this paper
• What Is Driving the Epidemiology of Methicillin-Resistant Staphylococcus aureus Infections in Europe?

  2020cited by this paper
• Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin

  2020cited by this paper
• Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties

  2020cited by this paper
• Potent Broad-Spectrum Antibacterial Activity of Amphiphilic Peptides against Multidrug-Resistant Bacteria

  2020cited by this paper
• Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria

  2020cited by this paper
• Local Photothermal/Photodynamic Synergistic Therapy by Disrupting Bacterial Membrane To Accelerate Reactive Oxygen Species Permeation and Protein Leakage.

  2019cited by this paper
• Drug combinations: a strategy to extend the life of antibiotics in the 21st century

  2019cited by this paper
• Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms

  2019cited by this paper
• Fosfomycin

  2019cited by this paper
• Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

  2019cited by this paper
• Repurposing ethyl bromopyruvate as a broad-spectrum antibacterial

  2019cited by this paper
• Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics.

  2018cited by this paper
• A new class of synthetic retinoid antibiotics effective against bacterial persisters

  2018cited by this paper
• Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology

  2018cited by this paper
• Repurposing of nucleoside- and nucleobase-derivative drugs as antibiotics and biofilm inhibitors

  2017cited by this paper
• The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

  2017cited by this paper
• Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

  2017cited by this paper
• Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes.

  2017cited by this paper
• Small Molecules That Sabotage Bacterial Virulence.

  2017cited by this paper
• Rapid and Efficient Genome Editing in Staphylococcus aureus by Using an Engineered CRISPR/Cas9 System.

  2017cited by this paper
• hybridSPAdes: an algorithm for hybrid assembly of short and long reads

  2016cited by this paper
• Prevention of Staphylococcus aureus biomaterial-associated infections using a polymer-lipid coating containing the antimicrobial peptide OP-145.

  2016cited by this paper
• Value added medicines: what value repurposed medicines might bring to society?

  2016cited by this paper
• Alternatives to antibiotics-a pipeline portfolio review.

  2016cited by this paper
• Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.

  2016cited by this paper
• Antibiotic efficacy is linked to bacterial cellular respiration

  2015cited by this paper
• Regulation of mammalian nucleotide metabolism and biosynthesis

  2015cited by this paper
• Reviving old antibiotics.

  2015cited by this paper
• Antibacterial monoclonal antibodies: the next generation?

  2015cited by this paper
• Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution.

  2015cited by this paper
• A new antibiotic kills pathogens without detectable resistance

  2015cited by this paper
• Update on the antibiotic resistance crisis.

  2014cited by this paper
• Pyrimidine nucleotide synthesis in Pseudomonas nitroreducens and the regulatory role of pyrimidines.

  2014cited by this paper
• Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus.

  2013cited by this paper
• ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors.

  2013cited by this paper
• The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium

  2013cited by this paper
• Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction

  2012cited by this paper
• Anti-infective external coating of central venous catheters: A randomized, noninferiority trial comparing 5-fluorouracil with chlorhexidine/silver sulfadiazine in preventing catheter colonization*

  2010cited by this paper
• 5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound

  2009cited by this paper
• Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.

  2009cited by this paper
• Advances in tuberculosis vaccine strategies

  2006cited by this paper
• Bactericidal Effect of Combinations of Antibiotic and Antineoplastic Agents against Staphylococcus aureus and Escherichia coli

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Radiochemical assay to measure the biofilm produced by coagulase-negative staphylococci on solid surfaces and its use to quantitate the effects of various antibacterial compounds on the formation of the biofilm.

  1992cited by this paper
• Effect of 5-fluorouracil, mitoxantrone, methotrexate, and vincristine on the antibacterial activity of ceftriaxone, ceftazidime, cefotiam, piperacillin, and netilmicin.

  1986cited by this paper
• THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.

  1958cited by this paper
• Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

  1957cited by this paper

• No citing papers are available for this paper.