The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Research

• Publication date

  2006-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-3353PMID 16885368
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

  2005influential reference
• Aurora C is directly associated with Survivin and required for cytokinesis

  2005cited by this paper
• Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

  2005cited by this paper
• Aurora-A — A guardian of poles

  2005cited by this paper
• Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

  2005cited by this paper
• Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.

  2004cited by this paper
• VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

  2004influential reference
• Aurora-kinase inhibitors as anticancer agents

  2004influential reference
• Cell death by mitotic catastrophe: a molecular definition

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• Cell cycle progression after cleavage failure

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• Triggering p53 after cytokinesis failure

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• G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instability.

  2003cited by this paper
• G1 tetraploidy checkpoint and the suppression of tumorigenesis

  2003cited by this paper
• The cellular geography of Aurora kinases

  2003cited by this paper
• The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

  2003cited by this paper
• Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells*

  2003cited by this paper
• Targeting Aurora-2 kinase in cancer.

  2003cited by this paper
• The Aurora kinases: Role in cell transformation and tumorigenesis

  2003cited by this paper
• Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

  2003influential reference
• Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

  2002cited by this paper
• Chromosomal passengers and the (aurora) ABCs of mitosis.

  2001cited by this paper
• Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

  2000cited by this paper
• Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.

  2000cited by this paper
• Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion.

  2000cited by this paper
• p21Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

  1999cited by this paper
• Mitotic kinase expression and colorectal cancer progression.

  1999cited by this paper
• Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.

  1999cited by this paper
• Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

  1998cited by this paper
• Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

  1998cited by this paper
• p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

  1998cited by this paper
• ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

  1998cited by this paper
• A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

  1998cited by this paper
• Tumor surveillance via the ARF-p53 pathway.

  1998cited by this paper
• Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

  1998cited by this paper
• A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

  1997cited by this paper

• Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

  2025cites this paper
• Aurora B inhibition induces polyploidy and mitotic catastrophe in HER2-amplified breast cancer: Telomere shortening as a potential anticancer mechanism of AZD1152-HQPA.

  2025cites this paper
• Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual aurora kinase A and B.

  2024cites this paper
• Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

  2024cites this paper
• Aurora B inhibition promotes a hyper-polyploid state and continued endomitotic cycles in RB and p53 defective cells

  2024cites this paper
• Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?

  2022cites this paper
• RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice

  2021cites this paper
• Neuroblastoma Cells Depend on CSB for Faithful Execution of Cytokinesis and Survival

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• The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects.

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• Aurora kinase inhibitor tozasertib suppresses mast cell activation in vitro and in vivo

  2020cites this paper
• Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

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• The landscape of gene co-expression modules correlating with prognostic genetic abnormalities in AML

  2020cites this paper
• Tumor-specific lytic path “hyperploid progression mediated death”: Resolving side effects through targeting retinoblastoma or p53 mutant

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• The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells.

  2020cites this paper
• Pro-survival Bcl-2 Proteins are Modifiers of MYC-VX-680 Synthetic Lethality

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• The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells

  2019cites this paper
• Targeting the chromosomal passenger complex subunit INCENP induces polyploidization, apoptosis and senescence in neuroblastoma.

  2019cites this paper
• A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition

  2019cites this paper
• Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma

  2018cites this paper
• Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

  2018cites this paper
• Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B.

  2018cites this paper
• An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression

  2018cites this paper
• Targeting bromodomain and extraterminal proteins in breast cancer

  2018cites this paper
• RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

  2018cites this paper
• Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death

  2018cites this paper
• A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.

  2017cites this paper
• Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response

  2017cites this paper
• Assessing the role of Ku 70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response

  2017cites this paper
• In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor.

  2016cites this paper
• The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line

  2016cites this paper
• Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases*

  2016cites this paper
• Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

  2016cites this paper
• Janus face-like effects of Aurora B inhibition : Anti-tumoral mode of action versus induction of aneuploid progeny Short title : Differential effects following Aurora B inhibition

  2016cites this paper
• Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction.

  2016cites this paper
• In vitro evaluation of Aurora kinase inhibitor—VX680—in formulation of PLA-TPGS nanoparticles

  2016cites this paper
• Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny.

  2016cites this paper
• Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

  2016cites this paper
• Antitumor Activity of KW-2450 against Triple- NegativeBreastCancerbyInhibitingAuroraAand

  2015cites this paper
• Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases

  2015cites this paper
• Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Authors and Affiliations:

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• Optimizing and predicting the in vivo activity of AT9283 as a monotherapy and in combination with paclitaxel

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• Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche

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• Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines

  2015cites this paper
• Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition.

  2015cites this paper
• Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma

  2015cites this paper
• Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A

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• Emerging kinase inhibitors of the treatment of gastric cancer

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• Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition

  2015cites this paper
• Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies

  2014cites this paper
• QUINASES EM CARCINOMA DE ADRENAL

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• Implications of NEDD9 on AURKA activity: a biomarker for sensitization and therapeutic target in solid tumors.

  2014cites this paper
• Mecanismos Envolvidos com a Inibição de Aurora-Quinases em Carcinoma de Adrenal

  2014influential citation
• Induction of p21CIP1 Protein and Cell Cycle Arrest after Inhibition of Aurora B Kinase Is Attributed to Aneuploidy and Reactive Oxygen Species*

  2014cites this paper
• p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

  2014cites this paper
• AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues

  2014cites this paper
• Radiosensitization by combining an aurora kinase inhibitor with radiotherapy in hepatocellular carcinoma through cell cycle interruption

  2014cites this paper
• A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia

  2014cites this paper
• Aurora kinase inhibition as an anticancer strategy.

  2014cites this paper
• Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F

  2013cites this paper
• Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors

  2013cites this paper
• Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

  2013cites this paper
• AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53

  2013cites this paper
• MK-0457, an Aurora kinase and BCR–ABL inhibitor, is active in patients with BCR–ABL T315I leukemia

  2013cites this paper
• Mitosis as an anti-cancer drug target

  2013cites this paper
• The dual Aurora kinase inhibitor ZM447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity.

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• Pazopanib Enhances Paclitaxel-Induced Mitotic Catastrophe in Anaplastic Thyroid Cancer

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• Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.

  2013cites this paper
• Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK.

  2013cites this paper
• A role for p38 in transcriptional elongation of p21CIP1 in response to Aurora B inhibition

  2013cites this paper
• Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells

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• Differentially expressed epigenome modifiers, including Aurora kinase A and B, in immune cells of rheumatoid arthritis

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• Orally Active Aurora A/B Kinase Inhibitor, AM‐005, Suppresses the Growth of Human Colon Carcinoma Cells

  2013influential citation
• Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity.

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• Sensitivity of BRCA2 mutated human cell lines to Aurora kinase inhibition

  2012cites this paper
• The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma.

  2012cites this paper
• Chimiothérapie ciblant les cellules cancéreuses p53 déficientes

  2012cites this paper
• Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy

  2012cites this paper
• The spindle assembly checkpoint as a drug target - Novel small-molecule inhibitors of Aurora kinases

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• Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells

  2012influential citation
• Target Validation and Biomarker Identification in Oncology

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• Prognostic and Predictive Value of Cell Cycle Deregulation in Non-Small-Cell Lung Cancer

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• The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent

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• Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence after Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts

  2012cites this paper
• Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

  2012cites this paper
• Transcriptional analysis of the Aurora inhibitor Danusertib leading to biomarker identification in TP53 wild type cells.

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• Activity of the aurora kinase B inhibitor AZD1152 in acute myeloid leukaemia

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• An Integrated Genomic Approach to Identify Predictive Biomarkers of Response to the Aurora Kinase Inhibitor PF-03814735

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• Inhibiting the aurora B kinase potently suppresses repopulation during fractionated irradiation of human lung cancer cell lines.

  2012cites this paper
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  2012cites this paper
• Preclinical Development Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence after Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts

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  2012cites this paper
• Selective killing of p53-deficient cancer cells by SP600125

  2012cites this paper
• Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment.

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• BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

  2011influential citation
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• Aurora kinase inhibitor patents and agents in clinical testing: an update (2009 – 10)

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• Targeting aneuploid cancer cells

  2011cites this paper