The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Immunology

• Publication date

  2016-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1600343PMID 27382129PMCID PMC4936486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV Drug Resistance.

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  2016influential reference
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  2016cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
• Understanding HIV latency: the road to an HIV cure.

  2015cited by this paper
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  2015cited by this paper
• Resident memory T cells in human health and disease

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