Role of PDX-1 and MafA as a potential therapeutic target for diabetes.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Diabetes Research and Clinical Practice

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.DIABRES.2007.01.046PMID 17449132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.

  2006cited by this paper
• Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.

  2006cited by this paper
• Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.

  2006cited by this paper
• MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

  2005cited by this paper
• Genetic determinants of pancreatic epsilon-cell development.

  2005cited by this paper
• Mechanism of PDX-1 protein transduction.

  2005cited by this paper
• Endodermal expression of Nkx6 genes depends differentially on Pdx1.

  2005cited by this paper
• Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration.

  2005cited by this paper
• Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

  2005cited by this paper
• Constitutively active PDX1 induced efficient insulin production in adult murine liver.

  2005cited by this paper
• TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro.

  2005cited by this paper
• A Crucial Role of MafA as a Novel Therapeutic Target for Diabetes*♦

  2005cited by this paper
• PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance.

  2005cited by this paper
• BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.

  2005cited by this paper
• Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell Function

  2004cited by this paper
• Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

  2004cited by this paper
• The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.

  2004cited by this paper
• Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting.

  2004cited by this paper
• PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.

  2004cited by this paper
• In vitro transdifferentiation of adult pancreatic acinar cells into insulin-expressing cells.

  2004cited by this paper
• Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

  2004cited by this paper
• In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow.

  2004cited by this paper
• High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells.

  2004cited by this paper
• The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

  2003cited by this paper
• PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.

  2003cited by this paper
• Experimental conversion of liver to pancreas.

  2003cited by this paper
• Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells.

  2003cited by this paper
• β-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas

  2003cited by this paper
• Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells

  2003cited by this paper
• Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.

  2003cited by this paper
• NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

  2003cited by this paper
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.

  2003cited by this paper
• Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer.

  2003cited by this paper
• Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

  2003cited by this paper
• The Islet β Cell-enriched RIPE3b1/Maf Transcription Factor Regulates pdx-1 Expression*

  2003cited by this paper
• Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion*

  2002cited by this paper
• PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells.

  2002cited by this paper
• The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

  2002cited by this paper
• Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

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• Conserved Sequences in a Tissue-Specific Regulatory Region of the pdx-1 Gene Mediate Transcription in Pancreatic β Cells: Role for Hepatocyte Nuclear Factor 3β and Pax6

  2002cited by this paper
• MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene*

  2002cited by this paper
• Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

  2002cited by this paper
• Experimental control of pancreatic development and maintenance

  2002cited by this paper
• In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells

  2002cited by this paper
• Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA

  2002cited by this paper
• Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β

  2002cited by this paper
• Cell‐specific transgene expression from a widely transcribed promoter using Cre/lox in mice

  2002cited by this paper
• Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

  2002cited by this paper
• Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.

  2002cited by this paper
• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.

  2002cited by this paper
• Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation*

  2001cited by this paper
• Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

  2001cited by this paper
• Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.

  2001cited by this paper
• A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factors.

  2001cited by this paper
• The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.

  2001cited by this paper
• Diabetes mellitus and genetically programmed defects in beta-cell function.

  2001cited by this paper
• The Role of Hepatic Nuclear Factor 1α and PDX-1 in Transcriptional Regulation of the pdx-1 Gene*

  2001cited by this paper
• A Pancreatic β-Cell-specific Enhancer in the HumanPDX-1 Gene Is Regulated by Hepatocyte Nuclear Factor 3β (HNF-3β), HNF-1α, and SPs Transcription Factors*

  2001cited by this paper
• Diabetes mellitus and genetically programmed defects in β-cell function

  2001cited by this paper
• PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.

  2001cited by this paper
• Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes.

  2001cited by this paper
• Insulin production by human embryonic stem cells.

  2001cited by this paper
• Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

  2001cited by this paper
• Functional Conservation of Regulatory Elements in thepdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific Expression

  2000cited by this paper
• Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

  2000cited by this paper
• Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells

  2000cited by this paper
• Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.

  2000cited by this paper
• Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

  2000cited by this paper
• In vitro cultivation of human islets from expanded ductal tissue.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1.

  1999cited by this paper
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  1999cited by this paper
• Identification of a Portable Repression Domain and an E1A-Responsive Activation Domain in Pax4: a Possible Role of Pax4 as a Transcriptional Repressor in the Pancreas

  1999cited by this paper
• Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

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• Paired-Homeodomain Transcription Factor PAX4 Acts as a Transcriptional Repressor in Early Pancreatic Development

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  1999cited by this paper
• Regulatory factor linked to late-onset diabetes?

  1998cited by this paper
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  1998cited by this paper
• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development

  1997cited by this paper
• Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

  1997cited by this paper
• Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

  1997cited by this paper
• Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1

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  1996cited by this paper
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  1996cited by this paper

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