Synthesis of Rumphellaone A and Hushinone by a Gold-Catalyzed [2 + 2] Cycloaddition

The enantioselective total synthesis of rumphellaone A has been accomplished in 12 steps via a diastereoselective gold(I)-catalyzed [2 + 2] macrocyclization of a 1,10-enyne as the key step to build the cyclobutene moiety. This concise approach has also led to the total synthesis of husinone.

• Publication year

  2016

• Venue

  Organic Letters

• Publication date

  2016-03-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.6b00473PMID 26974011PMCID 4820790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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