Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury*

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Critical Care Medicine

• Publication date

  2008-09-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/CCM.0b013e318186a4a0PMID 18766106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
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  2007cited by this paper
• Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis

  2006cited by this paper
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  2006cited by this paper
• Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study

  2005influential reference
• Alcohol Abuse and Traumatic Brain Injury: Quantitative Magnetic Resonance Imaging and Neuropsychological Outcome

  2004cited by this paper
• Persistently Low Extracellular Glucose Correlates with Poor Outcome 6 Months after Human Traumatic Brain Injury despite a Lack of Increased Lactate: A Microdialysis Study

  2003cited by this paper
• Assessment of the Lower Limit for Cerebral Perfusion Pressure in Severe Head Injuries by Bedside Monitoring of Regional Energy Metabolism

  2003cited by this paper
• Detection of secondary insults by brain tissue pO2 and bedside microdialysis in severe head injury.

  2002cited by this paper
• Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis.

  2002cited by this paper
• Traumatic brain injury and atrophy of the cingulate gyrus.

  2002cited by this paper
• Delayed Hemispheric Neuronal Loss in Severely Head-Injured Patients

  2001cited by this paper
• Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions

  2001cited by this paper
• Correlation of atrophy measures on MRI with neuropsychological sequelae in children and adolescents with traumatic brain injury.

  2001cited by this paper
• MRI analysis of brain atrophy after severe closed-head injury: relation to clinical status.

  2000cited by this paper
• Fornix and hippocampal atrophy in traumatic brain injury.

  2000cited by this paper
• Reduction of corpus callosum growth after severe traumatic brain injury in children

  2000cited by this paper
• Extracellular glutamate and aspartate in head injured patients.

  2000cited by this paper
• On-line monitoring of substrate delivery and brain metabolism in head injury.

  2000cited by this paper
• Head trauma and intellectual status: relation to quantitative magnetic resonance imaging findings.

  1999cited by this paper
• Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis.

  1999cited by this paper
• Factors affecting excitatory amino acid release following severe human head injury.

  1998cited by this paper
• Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study.

  1998cited by this paper
• Structured Interviews for the Glasgow Outcome Scale and the Extended Glasgow Outcome Scale: Guidelines for Their Use

  1998influential reference
• Simultaneous Intracerebral Microdialysis and Positron Emission Tomography in the Detection of Ischemia in Patients with Subarachnoid Hemorrhage

  1996cited by this paper
• Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life.

  1995cited by this paper
• Ventricle size, cortical atrophy and the relationship with neuropsychological status in closed head injury: a quantitative analysis.

  1986cited by this paper

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• Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring

  2025cites this paper
• Fundamentals of Care for Severe Traumatic Brain Injury: Induced Normality-The Battle to Restore Parameters in Critical Care Management.

  2025cites this paper
• Metabolic reprogramming and astrocytes polarization following ischemic stroke.

  2025cites this paper
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  2024cites this paper
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• Preliminary Observations of the Loke Microdialysis in an Experimental Pig Model: Are We Ready for Continuous Monitoring of Brain Energy Metabolism?

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• Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury

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• Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI

  2024cites this paper
• Friedman's Gradient-Boosting Algorithm Predicts Lactate-Pyruvate Ratio Predicts Trends in Cases of Intracerebral Hemorrhages.

  2024cites this paper
• Methodological and analytical considerations for intra-operative microdialysis

  2023cites this paper
• Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability

  2023cites this paper
• Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury

  2023influential citation
• Multimodal monitoring: practical recommendations (dos and don'ts) in challenging situations and uncertainty

  2023cites this paper
• Glioma Metabolic Feedback In Situ: A First-In-Human Pharmacodynamic Trial of Difluoromethylornithine + AMXT-1501 Through High-Molecular Weight Microdialysis.

  2023cites this paper
• Astrocyte-mediated mechanisms contribute to traumatic brain injury pathology.

  2023cites this paper
• Microdialysis-Based Classifications of Abnormal Metabolic States after Traumatic Brain Injury: A Systematic Review of the Literature

  2022cites this paper
• Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass

  2022cites this paper
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• Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model

  2022cites this paper
• Cerebral Metabolic Dysfunction at the Acute Phase of Traumatic Brain Injury Correlates with Long-Term Tissue Loss

  2022influential citation
• The extended scope of neuroimaging and prospects in brain atrophy mitigation: A systematic review

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Biofluid Biomarkers in Traumatic Brain Injury: A Systematic Scoping Review

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Using Cerebral Metabolites to Guide Precision Medicine for Subarachnoid Hemorrhage: Lactate and Pyruvate

  2019cites this paper
• Epileptic activity in neurological deterioration after ischemic stroke, a continuous EEG study.

  2019influential citation
• Intracranial Monitoring in the Neurocritical Care Unit

  2019cites this paper
• Design paper of the “Blood pressure targets in post-resuscitation care and bedside monitoring of cerebral energy state: a randomized clinical trial”

  2019cites this paper
• High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Multiplexed and fully automated detection of metabolic biomarkers using microdialysis probe.

  2017cites this paper
• Biochemical changes in the injured brain

  2017cites this paper
• Cerebrospinal fluid and brain extracellular fluid in severe brain trauma.

  2017cites this paper
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  2017cites this paper
• Multimodal neurologic monitoring.

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Role of Metabolomics in Traumatic Brain Injury Research.

  2016cites this paper
• Glucose control in acute brain injury: does it matter?

  2016cites this paper
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  2016cites this paper
• Mild Traumatic Brain Injury.

  2016cites this paper
• Monitoring metabolic parameters of the ischaemic brain

  2016cites this paper
• Role of metabolomics in TBI research

  2016cites this paper
• Monitoring in the Neurocritical Care Unit

  2015cites this paper
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  2015cites this paper
• Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification

  2015cites this paper
• Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model

  2015cites this paper
• Consensus statement from the 2014 International Microdialysis Forum

  2015cites this paper
• Quantitative assessments of traumatic axonal injury in human brain: concordance of microdialysis and advanced MRI.

  2015cites this paper
• Catecholamines as Independent Predictors of Outcome in Moderate and Severe Traumatic Brain Injury (TBI). The COMA-TBI Study

  2015cites this paper
• Translational Metabolomics of Head Injury

  2015cites this paper
• Contribution of brain or biological reserve and cognitive or neural reserve to outcome after TBI: A meta-analysis (prior to 2015).

  2015cites this paper
• Sleep disruption and the sequelae associated with traumatic brain injury.

  2015cites this paper
• Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain.

  2015cites this paper
• Equine lamellar energy metabolism studied using tissue microdialysis.

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• Glycemic control after brain injury: boon and bane for the brain.

  2014cites this paper
• Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care

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  2014cites this paper
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• Lactate Shuttling and Lactate use as Fuel after Traumatic Brain Injury: Metabolic Considerations

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• Perioperative microdialysis in meningioma surgery: correlation of cerebral metabolites with clinical outcome

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• Monitoring of acute traumatic brain injury in adults to prevent secondary brain damage

  2014cites this paper
• Continuous Online Microdialysis Using Microfluidic Sensors: Dynamic Neurometabolic Changes during Spreading Depolarization

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  2013cites this paper
• Insights into the metabolic response to traumatic brain injury as revealed by 13C NMR spectroscopy

  2013cites this paper
• Prognosis in Severe Brain Injury

  2013cites this paper
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  2013cites this paper
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