Na+‐Dependent “Binding” of D‐Aspartate in Brain Membranes Is Largely Due to Uptake into Membrane‐Bounded Saccules

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Journal of Neurochemistry

• Publication date

  1986-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1471-4159.1986.tb00684.xPMID 2874193
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cations differentially affect subpopulations of L-glutamate receptors in rat synaptic plasma membranes.

  1985cited by this paper
• Neurotoxicity of L‐Glutamate and DL‐Threo‐3‐Hydroxyaspartate in the Rat Striatum

  1985cited by this paper
• Low concentrations of potassium inhibit the Na-dependent [3H]glutamate binding to rat hippocampal membranes.

  1984cited by this paper
• Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors.

  1984cited by this paper
• Chronic infusion of L-glutamate causes neurotoxicity in rat striatum.

  1984cited by this paper
• Uptake of D-aspartate and L-glutamate in excitatory axon terminals in hippocampus: autoradiographic and biochemical comparison with gamma-aminobutyrate and other amino acids in normal rats and in rats with lesions.

  1984cited by this paper
• The Ca2+/Cl− dependent L‐[3H]glutamate binding: a new receptor or a particular transport process?

  1984cited by this paper
• Glutamate: A Neurotransmitter in Mammalian Brain

  1984cited by this paper
• Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

  1983cited by this paper
• Purification and Molecular Characterization of the Brain Synaptic Membrane Glutamate‐Binding Protein

  1983cited by this paper
• Binding order of substrates to the sodium and potassium ion coupled L-glutamic acid transporter from rat brain.

  1982cited by this paper
• Specific High‐Affinity Binding of L‐[3H]Aspartate to Rat Brain Membranes

  1982cited by this paper
• Striatal glutamatergic function: Modifications following specific lesions

  1982cited by this paper
• Glutamate, aspartate, and γ-aminobutyrate transport by membrane vesicles prepared from rat brain

  1981cited by this paper
• Glutamate, aspartate, and gamma-aminobutyrate transport by membrane vesicles prepared from rat brain.

  1981cited by this paper
• Characterization of Two [3H]Glutamate Binding Sites in Rat Hippocampal Membranes

  1981cited by this paper
• Ligand: a versatile computerized approach for characterization of ligand-binding systems.

  1980cited by this paper
• Potentiation of L‐Glutamate and L‐Aspartate Excitation of Cat Spinal Neurones by the Stereoisomers of threo‐3‐Hydroxyaspartate

  1980cited by this paper
• A comparison of sodium-dependent glutamate binding with high-affinity glutamate uptake in rat striatum.

  1980cited by this paper
• Regulation of glutamate receptors by cations

  1979cited by this paper
• Active transport of L-glutamate by membrane vesicles isolated from rat brain.

  1978cited by this paper
• HIGH AFFINITY l‐[3H]GLUTAMATE BINDING TO POSTSYNAPTIC RECEPTOR SITES ON RAT CEREBELLAR MEMBRANES

  1978cited by this paper
• UPTAKE AND RELEASE OF D‐ AND L‐ASPARTATE BY RAT BRAIN SLICES

  1976cited by this paper
• RELEASE AND EXCHANGE STUDIES RELATING TO THE SYNAPTOSOMAL UPTAKE OF GABA

  1975cited by this paper
• Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system.

  1974cited by this paper
• Glutamate receptors in the rat central nervous system

  1974cited by this paper
• THE STRUCTURAL SPECIFICITY OF THE HIGH AFFINITY UPTAKE OF l‐GLUTAMATE AND l‐ASPARTATE BY RAT BRAIN SLICES

  1972cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine

  2018cites this paper
• Neuronal vs glial glutamate uptake: Resolving the conundrum.

  2016cites this paper
• Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

  2015cites this paper
• ConditionalDeletionoftheGlutamateTransporterGLT-1 RevealsThatAstrocyticGLT-1ProtectsagainstFatal EpilepsyWhileNeuronalGLT-1ContributesSignificantlyto GlutamateUptakeintoSynaptosomes

  2015cites this paper
• Glutamate as a neurotransmitter in the healthy brain

  2014cites this paper
• EAAT2 (GLT-1; slc1a2) Glutamate Transporters Reconstituted in Liposomes Argues against Heteroexchange Being Substantially Faster than Net Uptake

  2014cites this paper
• Activation of sodium‐dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin‐dependent kinase IIβ's actin‐binding/‐stabilizing domain

  2014cites this paper
• GABA and Glutamate Transporters in Brain

  2013cites this paper
• Calcium/Calmodulin-Dependent Protein Kinase II Beta (CaMKIIβ): A Regulator of Oligodendrocyte Maturation and Myelination

  2013cites this paper
• D-Aspartate: An Atypical Amino Acid with Neuromodulatory Activity in Mammals

  2009cites this paper
• Glutamate transport - relative rates of net uptake and heteroexchange.

  2008cites this paper
• Comparison of [(3)H]-(2S,4R)-4-methylglutamate and [(3)H]D-aspartate as ligands for binding and autoradiographic analyses of glutamate transporters.

  2007cites this paper
• D-aspartate binding to the glutamate uptake site in human brain tissue — effects of leucotomy

  2005cites this paper
• Dopaminergic and Glutamatergic Systems in Alzheimer’s Disease

  2005cites this paper
• The Na+-dependent binding of [3H]l-aspartate in thaw-mounted sections of rat forebrain

  2004cites this paper
• Retinal glutamate transporter activity persists under simulated ischemic conditions

  2004cites this paper
• Effects of Isoflurane and Propofol on Glutamate and GABA Transporters in Isolated Cortical Nerve Terminals

  2003cites this paper
• Glutamatergic systems in Alzheimer's disease

  2003cites this paper
• Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

  2003cites this paper
• [3H](2S,4R)‐4‐Methylglutamate: a novel ligand for the characterization of glutamate transporters

  2001cites this paper
• Glutamate uptake.

  2001cites this paper
• Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.

  2001cites this paper
• Quantitative autoradiography of Na+-dependent [3H]L-aspartate binding to L-glutamate transporters in rat brain: structure-activity studies using L-trans-pyrrolidine-2,4-dicarboxylate (L-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG).

  2000cites this paper
• Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease

  1999cites this paper
• Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels.

  1998cites this paper
• Properties and localization of glutamate transporters.

  1998cites this paper
• Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system.

  1997cites this paper
• Free D-aspartate and D-serine in the mammalian brain and periphery.

  1997cites this paper
• Variant Forms of Neuronal Glutamate Transporter Sites in Alzheimer's Disease Cerebral Cortex

  1995cites this paper
• Sensitivity of the binding sites on glutamate transporters to neurotoxic agents.

  1995cites this paper
• Effects of l-trans-pyrrolidine-2,4-dicar☐ylate and l-threo-3-hydroxyaspartate on the binding of [3H] l-aspartate, [3H]α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H] dl-(E)-2-amino-4-propyl-5-phosphono-3pentenoate (cgp 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) [3H]kainate

  1995cites this paper
• Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3

  1995cites this paper
• The high affinity uptake system for excitatory amino acids in the brain.

  1994cites this paper
• Neuronal pathology in relation to molecular biology and treatment of Alzheimer's disease.

  1994cites this paper
• Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate.

  1994cites this paper
• Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

  1993cites this paper
• Glutamate dehydrogenase improves binding of [3H]CGP39653 to NMDA receptors in the autoradiographic assay.

  1993cites this paper
• Demonstration of glutamate/aspartate uptake activity in nerve endings by use of antibodies recognizing exogenous D-aspartate.

  1993cites this paper
• Age-related changes in binding to excitatory amino acid uptake site in temporal cortex of human brain.

  1992cites this paper
• An [Na+ + K+]coupled L-glutamate transporter purified from rat brain is located in glial cell processes.

  1992cites this paper
• Animal and drug modelling for Alzheimer synaptic pathology.

  1992cites this paper
• D-[3H]aspartate and [14C]GABA uptake in the basal ganglia of rats following lesions in the subthalamic region suggest a role for excitatory amino acid but not GABA-mediated transmission in subthalamic nucleus efferents.

  1991cites this paper
• Sodium-dependent D-aspartate 'binding' is not a measure of presynaptic neuronal uptake sites in an autoradiographic assay.

  1990cites this paper
• Region-selective stress-induced increase of glutamate uptake and release in rat forebrain.

  1990cites this paper
• Autoradiographic characterization of putative excitatory amino acid transport sites.

  1990cites this paper
• Aging and stress‐induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors

  1990cites this paper
• L-[35S]cysteic acid selectively detects chloride-dependent L-glutamate transporters in synaptic membrane.

  1989cites this paper
• Reduced D-[3H]aspartate binding in Down's syndrome brains.

  1989cites this paper
• Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals.

  1989cites this paper
• Depolarization Increases Chloride‐Dependent Glutamate Sequestration in Synaptic Membranes of Rat Cerebral Cortex

  1989cites this paper
• L‐[3H]Glutamate Binding to a Membrane Preparation from Crayfish Muscle

  1989cites this paper
• Glutamate Release from Guinea‐Pig Synaptosomes: Stimulation by Reuptake‐Induced Depolarization

  1989cites this paper
• Release of Glutamate, Aspartate, and γ‐Aminobutyric Acid from Isolated Nerve Terminals

  1989cites this paper
• Excitatory amino acids and Alzheimer's disease.

  1989cites this paper
• Topographical distribution of neurochemical changes in Alzheimer's disease.

  1988cites this paper
• Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

  1988cites this paper
• Glutamatergic denervation in Alzheimer's disease--a cautionary note.

  1987cites this paper
• Inhibition by K+ of Na+‐Dependent D‐Aspartate Uptake into Brain Membrane Saccules

  1986cites this paper