Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Basic Research in Cardiology

• Publication date

  2008-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00395-007-0691-yPMID 18080084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Impairment of cardioprotective PI3K-Akt signaling by post-infarct ventricular remodeling is compensated by an ERK-mediated pathway

  2007cited by this paper
• PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning.

  2006cited by this paper
• Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion.

  2006influential reference
• Mitochondrial Ca2+ uptake during simulated ischemia does not affect permeability transition pore opening upon simulated reperfusion.

  2006cited by this paper
• The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin

  2006cited by this paper
• Risk of death or acute myocardial infarction 10 years after coronary artery bypass surgery in relation to type of diabetes.

  2006influential reference
• Metformin delays the manifestation of diabetes and vascular dysfunction in Goto–Kakizaki rats by reduction of mitochondrial oxidative stress

  2006cited by this paper
• Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3

  2006cited by this paper
• Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca2+ storage.

  2006cited by this paper
• Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

  2006cited by this paper
• Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

  2006cited by this paper
• Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection.

  2006cited by this paper
• Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.

  2005cited by this paper
• Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.

  2005cited by this paper
• Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: a potential role for phosphatase and tensin homolog deleted on chromosome ten?

  2005cited by this paper
• Postconditioning Inhibits Mitochondrial Permeability Transition

  2005cited by this paper
• Preconditioning the diabetic heart: the importance of Akt phosphorylation.

  2005cited by this paper
• LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.

  2005influential reference
• Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

  2004cited by this paper
• Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention.

  2004cited by this paper
• Outcomes in Patients With Diabetes Mellitus Undergoing Percutaneous Coronary Intervention in the Current Era: A Report From the Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) Trial

  2004cited by this paper
• Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.

  2004cited by this paper
• New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway.

  2004cited by this paper
• Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning.

  2004cited by this paper
• Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

  2004cited by this paper
• Preconditioning protects by inhibiting the mitochondrial permeability transition.

  2004influential reference
• Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore.

  2004cited by this paper
• Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes.

  2004cited by this paper
• Calcium‐dependent mitochondrial permeability transition is augmented in the kidney of Goto‐Kakizaki diabetic rat

  2004cited by this paper
• Effect of diabetes on early and late survival after isolated first coronary bypass surgery in multivessel disease.

  2003influential reference
• Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

  2003cited by this paper
• Cardioprotection by metformin is abolished by a nitric oxide synthase inhibitor in ischemic rabbit hearts.

  2003cited by this paper
• The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion.

  2003cited by this paper
• Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin‐induced diabetic rats

  2003cited by this paper
• Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

  2002cited by this paper
• Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition pore.

  2002cited by this paper
• Metformin improves cardiac functional recovery after ischemia in rats.

  2002cited by this paper
• Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes.

  2002cited by this paper
• The permeability transition pore signals apoptosis by directing Bax translocation and multimerization

  2002cited by this paper
• Metformin: An Update

  2002cited by this paper
• Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex*

  2001cited by this paper
• Role of AMP-activated protein kinase in mechanism of metformin action.

  2001influential reference
• Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb Study

  2000influential reference
• Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction: Results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry

  2000cited by this paper
• Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I*

  2000cited by this paper
• Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators.

  2000cited by this paper
• Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

  2000cited by this paper
• MORTALITY FROM CORONARY HEART DISEASE IN SUBJECTS WITH TYPE 2 DIABETES AND IN NONDIABETIC SUBJECTS WITH AND WITHOUT PRIOR MYOCARDIAL INFARCTION

  2000influential reference
• Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes.

  1999cited by this paper
• Influence of diabetes mellitus on early and late outcome after coronary artery bypass grafting.

  1999influential reference
• Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore.

  1999cited by this paper
• Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections

  1998cited by this paper
• Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction.

  1998cited by this paper
• Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

  1998cited by this paper
• Imaging the permeability pore transition in single mitochondria.

  1998cited by this paper
• Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion.

  1995cited by this paper
• High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase (*)

  1995cited by this paper
• Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts.

  1994cited by this paper

• Hexokinase 2‐Driven Cardioprotection in Ischemia, Hypertrophy, and Regeneration: From Underlying Mechanisms to Clinical Translation

  2026cites this paper
• Understanding the Mechanisms of Chemotherapy-Related Cardiotoxicity Employing hiPSC-Derived Cardiomyocyte Models for Drug Screening and the Identification of Genetic and Epigenetic Variants

  2025cites this paper
• Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications

  2025cites this paper
• Effect of Metformin on Spontaneous Calcium Signaling in Cultured Astrocytes during Normoxic and Hypoxic Conditions.

  2025cites this paper
• High-dose metformin treatment to inhibit complex I during early reperfusion protects the aged mouse heart via decreased mitochondrial permeability transition pore opening.

  2024cites this paper
• Metformin and the PI3K/AKT signaling pathway: implications for cancer, cardiovascular, and central nervous system diseases

  2024cites this paper
• Metformin's cardioprotective role in isoprenaline-induced myocardial infarction: Unveiling insights into the AMPK, NF-κB, JAK2/STAT3 pathways, and cholinergic regulation.

  2024cites this paper
• Advance of Metformin in Liver Disease.

  2024cites this paper
• Effects of Metformin on Ischemia/Reperfusion Injury: New Evidence and Mechanisms

  2023cites this paper
• The RISK pathway leading to mitochondria and cardioprotection: how everything started

  2023cites this paper
• Targeting mitochondrial shape: at the heart of cardioprotection

  2023cites this paper
• Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury.

  2023cites this paper
• Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest

  2023cites this paper
• A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific

  2023cites this paper
• Metformin Protects Against Sunitinib-induced Cardiotoxicity: Investigating the Role of AMPK

  2022cites this paper
• Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study

  2022cites this paper
• Potential Protective Effect of Metformin and L-carnitine in rat model of Carboplatin-Induced Myelosuppression, Comparative Study

  2022cites this paper
• A comparative study of the cardioprotective effect of Metformin, Sitagliptin and Dapagliflozin on Isoprenaline induced myocardial infarction in non-diabetic rats

  2022cites this paper
• Protection by metformin against severe Covid-19: An in-depth mechanistic analysis

  2022cites this paper
• Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart

  2022cites this paper
• Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms

  2022cites this paper
• The Hormetic Effect of Metformin: “Less Is More”?

  2021cites this paper
• The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

  2021cites this paper
• Metformin Confers Cardiac and Renal Protection in Sudden Cardiac Arrest via AMPK Activation

  2021cites this paper
• Endothelium-dependent remote signaling in ischemia and reperfusion: alterations in the cardiometabolic continuum.

  2021cites this paper
• Effects of Metformin on Spontaneous Ca2+ Signals in Cultured Microglia Cells under Normoxic and Hypoxic Conditions

  2021influential citation
• Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies.

  2021cites this paper
• Metformin preconditioning protects against myocardial stunning and preserves mitochondrial dynamics and protein translation in a mouse model of cardiac arrest

  2021cites this paper
• Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway.

  2021cites this paper
• Galangin Resolves Cardiometabolic Disorders through Modulation of AdipoR1, COX-2, and NF-κB Expression in Rats Fed a High-Fat Diet

  2021cites this paper
• Metformin Preferentially Provides Neuroprotection Following Cardiac Ischemia/Reperfusion in Non-Diabetic Rats.

  2020cites this paper
• Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

  2020influential citation
• An α2-adrenoceptor agonist: Dexmedetomidine induces protective cardiomyocyte hypertrophy through mitochondrial-AMPK pathway

  2020cites this paper
• Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?

  2020cites this paper
• The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

  2020cites this paper
• Novel Targets of Metformin in Cardioprotection: Beyond the Effects Mediated by AMPK.

  2020cites this paper
• Different effects of metformin and phenformin on hypoxia-induced Ca2+ fluxes in cultured primary neurons.

  2020cites this paper
• Biphasic effect of metformin on human cardiac energetics.

  2020cites this paper
• Acute metformin treatment provides cardioprotection via improved mitochondrial function in cardiac ischemia / reperfusion injury.

  2020cites this paper
• Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation

  2020cites this paper
• Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury

  2020cites this paper
• Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension.

  2019cites this paper
• Treatment with metformin prevents myocardial ischemia–reperfusion injury via STEAP4 signaling pathway

  2019cites this paper
• Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction

  2019cites this paper
• Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.

  2019cites this paper
• Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature

  2019cites this paper
• The cardioprotective effect of dexmedetomidine on regional ischemia/reperfusion injury in type 2 diabetic rat hearts.

  2019cites this paper
• New advances in perioperative cardioprotection

  2019cites this paper
• Effects of metformin on the heart with ischaemia-reperfusion injury: Evidence of its benefits from in vitro, in vivo and clinical reports.

  2019cites this paper
• A review on the cardioprotective mechanisms of metformin against doxorubicin

  2019cites this paper
• A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure

  2019cites this paper
• Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

  2019cites this paper
• Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction

  2018cites this paper
• Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes.

  2018cites this paper
• Metformin Attenuated Hyperoxia Induced Oxidative Damages on Different Tissues in Young Rats

  2018cites this paper
• Metformin prevents the development of severe chronic kidney disease and its associated mineral and bone disorder.

  2018cites this paper
• Cardioprotective Effects of Metformin

  2018cites this paper
• Metformin Protects against H2O2-Induced Cardiomyocyte Injury by Inhibiting the miR-1a-3p/GRP94 Pathway

  2018cites this paper
• Anti-Angiogenic miR-222, miR-195, and miR-21a Plasma Levels in T1DM Are Improved by Metformin Therapy, Thus Elucidating Its Cardioprotective Effect: The MERIT Study

  2018cites this paper
• Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine

  2018cites this paper
• Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats.

  2018cites this paper
• Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging

  2018cites this paper
• Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition.

  2018cites this paper
• Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection

  2018cites this paper
• Effect of metformin on germ cell‐specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats

  2018cites this paper
• Autophagy—A key pathway for cardiac health and longevity

  2018cites this paper
• Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

  2018influential citation
• Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury

  2018cites this paper
• Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms.

  2017cites this paper
• Age-associated metabolic reprogramming, oxidative stress response, and cancer progression

  2017cites this paper
• Mitochondrial hexokinase and ischemic sensitivity and metabolism of the heart

  2017cites this paper
• The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

  2017cites this paper
• Factors Affecting The Cardioprotective Response To Remote Ischaemic Preconditioning In Patients Undergoing Cardiac Surgery

  2017cites this paper
• The effect of remote ischaemic preconditioning on contrast induced nephropathy in the clinical setting of coronary angiography and percutaneous coronary intervention

  2017cites this paper
• Two-year follow-up of 4 months metformin treatment vs. placebo in ST-elevation myocardial infarction: data from the GIPS-III RCT

  2017cites this paper
• Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells.

  2017cites this paper
• Cardioprotection: Where to from here?

  2017cites this paper
• The role of succinate and ROS in reperfusion injury – A critical appraisal

  2017cites this paper
• Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data.

  2017cites this paper
• The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

  2017cites this paper
• The burden of myocardial infarction

  2017cites this paper
• A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction

  2017cites this paper
• Metformin: New Preparations and Nonglycemic Benefits

  2017cites this paper
• Comparative Study of the Protective Effect of Metformin and Sitagliptin against Doxorubicin-Induced Cardiotoxicity in Rats

  2017cites this paper
• Remote ischaemic conditioning in the context of type 2 diabetes and neuropathy: the case for repeat application as a novel therapy for lower extremity ulceration

  2016cites this paper
• Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons

  2016cites this paper
• Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells.

  2016cites this paper
• Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model

  2016cites this paper
• Yang of MI Therapy

  2016cites this paper
• Research progress of cardioprotective agents for prevention of anthracycline cardiotoxicity.

  2016cites this paper
• Targeting the adenosine system to limit ischemia-reperfusion injury : translational research in humans

  2016cites this paper
• Comparison of the effects of EPA and DHA alone or in combination in a murine model of myocardial infarction.

  2016cites this paper
• Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.

  2016cites this paper
• Comparative Impact of Hypoglycemic Agents on Severity and Extent of Myocardial Ischemia in Patients With Type 2 Diabetes Mellitus Undergoing Myocardial Perfusion Scintigraphy

  2016cites this paper
• Potential Benefits of Metformin Use in Sickle Cell Anemia

  2016cites this paper
• Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?

  2016cites this paper
• Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.

  2016cites this paper
• Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury.

  2015cites this paper
• Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis

  2015cites this paper
• The effect of hexarelin in streptozotocin (STZ)-induced rat model through protective actions on islet beta cells and cardiomyocytes

  2015cites this paper