SCIENCE@home

Genetics of vascular dementia – review from the ICVD working group

M. Ikram,A. Bersano,R. Manso-Calderón,J. Jia,H. Schmidt,L. Middleton,B. Nacmias,S. Siddiqi,H. Adams

Published 2017 in BMC Medicine

ABSTRACT

BackgroundVascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice.DiscussionIn this review, we discuss what is currently known about the genetics of vascular dementia. The identification of causal genes remains limited to monogenic forms of the disease, with findings for sporadic vascular dementia being less robust. However, progress in genetic research on associated phenotypes, such as cerebral small vessel disease, Alzheimer’s disease, and stroke, have the potential to inform on the genetics of vascular dementia. We conclude by providing an overview of future developments in the field and how such work could impact patients and clinicians.ConclusionThe genetic background of vascular dementia is well established for monogenic disorders, but remains relatively obscure for the sporadic form. More work is needed for providing robust findings that might eventually lead to clinical translation.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-66 of 66 references · Page 1 of 1

CITED BY

Showing 1-67 of 67 citing papers · Page 1 of 1