The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: a meta-analysis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Neurological Sciences

• Publication date

  2010-07-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jns.2010.04.001PMID 20441995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature

  2009cited by this paper
• Association of ACE I/D Gene Polymorphism With Vascular Dementia: A Meta-Analysis

  2009cited by this paper
• Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer.

  2009cited by this paper
• Gene polymorphisms and risk of adult early-onset ischemic stroke: A meta-analysis.

  2009cited by this paper
• Plasma Homocysteine Levels and Different Forms of Vascular Disease in Patients with Dementia and Other Psychogeriatric Diseases

  2009cited by this paper
• Author ' s personal copy MTHFR and ACE gene polymorphisms and risk of vascular and degenerative dementias in the elderly

  2009cited by this paper
• Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment.

  2009cited by this paper
• P4‐108: MTHFR and ACE gene polymorphisms and risk of vascular and degenerative dementias in the elderly

  2009cited by this paper
• Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches.

  2008cited by this paper
• [Stroke and the genetics of hyperhomocysteinemia].

  2008cited by this paper
• Meta-Analysis of Genetic Studies from Journals Published in China of Ischemic Stroke in the Han Chinese Population

  2008cited by this paper
• The Epidemiology of vascular dementia.

  2008cited by this paper
• Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis

  2007cited by this paper
• Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.

  2007cited by this paper
• The Medical Research Council Cognitive Function and Ageing Study

  2007cited by this paper
• A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension

  2007cited by this paper
• Relations between homocysteine, folate and vitamin B12 in vascular dementia and in Alzheimer disease.

  2007cited by this paper
• Analysis of MTHFR C677T polymorphism in patients with SAD and VD

  2006cited by this paper
• Academic Editor: Peter Sandercock, Western General Hospital, United Kingdom

  2006cited by this paper
• Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

  2006cited by this paper
• Dementia and cerebrovascular disease.

  2006cited by this paper
• Differences in Risk Factors for Dementia with Neurodegenerative Traits and for Vascular Dementia

  2006cited by this paper
• A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints

  2006cited by this paper
• Global prevalence of dementia: a Delphi consensus study

  2005cited by this paper
• Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

  2005cited by this paper
• A method for meta‐analysis of molecular association studies

  2005cited by this paper
• Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia.

  2004cited by this paper
• The complex interplay among factors that influence allelic association

  2004cited by this paper
• Meta-analysis of genetic association studies.

  2004influential reference
• 'Racial' differences in genetic effects for complex diseases

  2004cited by this paper
• Metabolism of Homocysteine and its Relationship with Cardiovascular Disease

  2004cited by this paper
• Common polymorphisms in methylenetetrahydrofolate reductase (MTHFR): relationships with plasma homocysteine concentrations and cognitive status in elderly northern italian subjects.

  2004cited by this paper
• Survival study of vascular dementia in Rochester, Minnesota.

  2003cited by this paper
• Vascular dementia may be the most common form of dementia in the elderly.

  2002cited by this paper
• MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.

  2002cited by this paper
• Quantifying heterogeneity in a meta‐analysis

  2002cited by this paper
• Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

  2002cited by this paper
• Moderately Elevated Plasma Homocysteine, Methylenetetrahydrofolate Reductase Genotype, and Risk for Stroke, Vascular Dementia, and Alzheimer Disease in Northern Ireland

  2002cited by this paper
• BMC Medical Research Methodology BioMed Central BMC 22002, Medical Research Methodology

  2001cited by this paper
• Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia.

  2001influential reference
• Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia

  2001cited by this paper
• Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

  2001cited by this paper
• Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

  2001cited by this paper
• Increased prevalence of vascular dementia in Japan

  2001cited by this paper
• Genetics and ischaemic stroke.

  2000cited by this paper
• Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk of senile dementia--an epidemiological study using the polymerase chain reaction (PCR) method.

  2000cited by this paper
• Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.

  2000influential reference
• The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia

  2000cited by this paper
• ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia.

  1998cited by this paper
• Analysis of alpha-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia.

  1997cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

  1995influential reference
• Meta-analysis in clinical trials.

  1986cited by this paper
• A comparison of tests for Hardy-Weinberg equilibrium.

  1980cited by this paper
• Statistical aspects of the analysis of data from retrospective studies of disease.

  1959cited by this paper

• Vascular Dementia: From Pathophysiology to Therapeutic Frontiers

  2025cites this paper
• Unifying Vascular Injury and Neurodegeneration: A Mechanistic Continuum in Cerebral Small Vessel Disease and Dementia

  2025cites this paper
• Shared Neuroinflammatory Mechanisms Across Dementia Types: An Integrative Review

  2025cites this paper
• Retinal vascular dysfunction in the Mthfr677C>T mouse model of cerebrovascular disease

  2025cites this paper
• Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis

  2024cites this paper
• Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice

  2022cites this paper
• Hyperhomocysteinemia and Dementia Associated With Severe Cortical Atrophy, but No Amyloid Burden

  2021cites this paper
• Genetic variants and oxidative stress in Alzheimer's disease.

  2020cites this paper
• Coagulopathies

  2020cites this paper
• Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts

  2020cites this paper
• Vascular Dementia

  2020cites this paper
• Genetic architecture of common non-Alzheimer’s disease dementias

  2020cites this paper
• Genetics in vascular dementia

  2019cites this paper
• Genetic factors associated with the predisposition to late onset Alzheimer's disease.

  2019cites this paper
• MTHFR Gene Mutations Correlate with White Matter Disease Burden and Predict Cerebrovascular Disease and Dementia

  2019cites this paper
• Some biochemical changes in patients with acute ischemic stroke

  2017cites this paper
• The Role of B Group Vitamins and Choline in Cognition and Brain Aging

  2017cites this paper
• Assessment of Modifiable and Non-Modifiable Risk Factors of Dementia as Early Diagnostic Blood Based Biomarkers in Western Indian Population

  2017cites this paper
• Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk

  2017cites this paper
• Genetics of vascular dementia – review from the ICVD working group

  2017cites this paper
• Lebensstil und Demenz – Befunde und Überlegungen

  2017cites this paper
• Genetic and environmental factors in vascular dementia: an update of blood brain barrier dysfunction

  2016cites this paper
• Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing

  2016cites this paper
• A Validation Study of Vascular Cognitive Impairment Genetics Meta-Analysis Findings in an Independent Collaborative Cohort

  2016cites this paper
• Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population

  2016cites this paper
• Association of interleukin-10 polymorphisms with risk factors of Alzheimer's disease and other dementias (SADEM study).

  2016cites this paper
• The relationship between hyperhomocysteinemia and neurodegeneration.

  2016cites this paper
• Optimising the use of Azathioprine in the treatment of Inflammatory Bowel Disease

  2016cites this paper
• Genetic susceptibility to vascular cognitive impairment: a pathophysiological view

  2016cites this paper
• Genetic and Environmental Risk for Alzheimer's

  2016cites this paper
• Vascular dementia.

  2015cites this paper
• Transcobalamin 766G Homozygosity, Raised Homocysteine, Raised Methylmalonic Acid and High Creatinine: A Dementia-Predisposing Phenotype? Implications for Dementia and Alzheimer’s Disease

  2015influential citation
• Chapter 101 – Coagulopathies

  2015cites this paper
• Integration of Genomic Information in Development of Pharmacological Vascular Dementia Prevention and Treatment Strategies

  2014cites this paper
• Association Between MTHFR Gene Polymorphisms, Smoking, and the Incidence of Vascular Dementia

  2013cites this paper
• C 677 T and A 1298 C gene polymorphisms and sporadic early-onset Alzheimer ’ s disease

  2013cites this paper
• Using Alzgene-Like Approaches to Investigate Susceptibility Genes for Vascular Cognitive Impairment

  2013cites this paper
• C677T and A1298C gene polymorphisms and sporadic early-onset Alzheimer's disease

  2013cites this paper
• ANALISIS DE POLIMORFISMOS DE GENES RELACIONADOS CON LA FUNCION ENDOTELIAL Y LA MUERTE CELULAR EN DEMENCIA VASCULAR Y

  2013cites this paper
• Pharmacological prevention and treatment of vascular dementia: approaches and perspectives.

  2012cites this paper
• Pathology supported genetic testing and treatment of cardiovascular disease in middle age for prevention of Alzheimer’s disease

  2012influential citation
• Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

  2012cites this paper
• MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction.

  2012influential citation
• Effects of Folic Acid Supplementation on Human Leukocyte DNA Methylation and Gene Expression

  2011cites this paper
• Pharmacological investigations on potential of peroxisome proliferator-activated receptor-gamma agonists in hyperhomocysteinemia-induced vascular dementia in rats.

  2011cites this paper
• Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia

  2011cites this paper
• Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats.

  2011cites this paper
• The -1082G/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: a meta-analysis.

  2011cites this paper
• Some biochemical changeS in patientS with acute iSchemic Stroke

  year unknowncites this paper