Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Cancer Research

• Publication date

  1995-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7553622
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.

  1995cited by this paper
• High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder.

  1995cited by this paper
• Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.

  1995cited by this paper
• Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

  1995cited by this paper
• Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability.

  1995cited by this paper
• Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

  1994cited by this paper
• Rates of p16 (MTS1) mutations in primary tumors with 9p loss.

  1994cited by this paper
• Homozygous deletions within chromosomal bands 9p21-22 in bladder cancer.

  1994cited by this paper
• Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

  1994cited by this paper
• Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

  1994cited by this paper
• Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.

  1994cited by this paper
• DNA methylation and cancer.

  1994cited by this paper
• A cell cycle regulator potentially involved in genesis of many tumor types.

  1994cited by this paper
• P16 gene in uncultured tumours

  1994cited by this paper
• Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

  1994cited by this paper
• Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction.

  1994cited by this paper
• p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

  1994cited by this paper
• Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

  1994influential reference
• Parental-origin-specific epigenetic modification of the mouse H19 gene

  1993cited by this paper
• Proposed roles for DNA methylation in Alu transcriptional repression and mutational inactivation.

  1993cited by this paper
• A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

  1993cited by this paper
• X chromosome inactivation and DNA methylation.

  1993cited by this paper
• Homozygous deletions within human chromosome band 9p21 in melanoma.

  1992cited by this paper
• The role of DNA methylation in cancer.

  1990cited by this paper
• CpG islands in vertebrate genomes.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• CpG-rich islands and the function of DNA methylation

  1986cited by this paper
• Cellular differentiation, cytidine analogs and DNA methylation.

  1980cited by this paper

• RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection

  2025cites this paper
• GSK-3484862, a DNMT1 degrader, promotes DNMT3B expression in lung cancer cells

  2025cites this paper
• Early detection and diagnosis of cancer with interpretable machine learning to uncover cancer-specific DNA methylation patterns

  2024cites this paper
• Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas

  2024cites this paper
• DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations

  2024cites this paper
• The Epigenetic Hallmarks of Cancer.

  2024cites this paper
• Quinoline-based compounds can inhibit diverse enzymes that act on DNA

  2024cites this paper
• Conserved epigenetic hallmarks of T cell aging during immunity and malignancy

  2024cites this paper
• Quinoline-based compounds can inhibit diverse enzymes that act on DNA.

  2024cites this paper
• Oncogenes and tumor suppressor genes: functions and roles in cancers

  2024cites this paper
• The emerging field of opportunities for single-cell DNA methylation studies in hematology and beyond

  2023cites this paper
• Potential biomarkers for immunotherapy in non-small-cell lung cancer

  2023cites this paper
• Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer

  2023influential citation
• Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening

  2023cites this paper
• TBX20 inhibits colorectal cancer tumorigenesis by impairing NHEJ‐mediated DNA repair

  2022cites this paper
• Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA

  2022cites this paper
• Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent Updates

  2022cites this paper
• Screening of potential novel candidate genes in schwannomatosis patients

  2022cites this paper
• Hypomethylating agent-based therapies in older adults with acute myeloid leukemia - A joint review by the Young International Society of Geriatric Oncology and European Society for Blood and Marrow Transplantation Trainee Committee.

  2022cites this paper
• Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

  2022cites this paper
• DNA Methylation Patterns in CD4+ T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand

  2021cites this paper
• Distinct cytosine modification profiles define epithelial-to-mesenchymal cell-state transitions

  2021cites this paper
• CRISPR/Cas9 in epigenetics studies of health and disease.

  2021cites this paper
• Relevance of pRB Loss in Human Malignancies

  2021cites this paper
• Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer

  2021cites this paper
• Distinct Cytosine Modi cation Pro les De ne Epithelial-to-Mesenchymal Cell-State Transitions

  2021cites this paper
• Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

  2021cites this paper
• Title: Targeted intragenic demethylation initiates chromatin rewiring for gene activation

  2020cites this paper
• TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.

  2020cites this paper
• Title: Targeted intragenic demethylation initiates chromatin rewiring for gene activation

  2020cites this paper
• Machine Classification of Methylomes in Cancer

  2020cites this paper
• Targeted intragenic demethylation initiates chromatin rewiring for gene activation

  2020cites this paper
• Polyunsaturated fatty acids and DNA methylation in colorectal cancer

  2019cites this paper
• Epigenetic regulation of lysine acetylation: targeting writers, readers and erasers in cancer

  2019cites this paper
• Assessment of p16 Tumour Suppressor Protein Expression In Oral Mucosa of Smokers And Paan Chewers using Immunohistochemistry

  2019cites this paper
• Clinical update on hypomethylating agents

  2019cites this paper
• Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults

  2019cites this paper
• Microfluidic MeDIP-seq for low-input methylomic analysis of mammary tumorigenesis in mice.

  2019cites this paper
• Age estimation by DNA methylation in the Antarctic minke whale

  2019cites this paper
• MeCP2 level is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral therapy.

  2018cites this paper
• CDKN2A/P16INK4A variants association with breast cancer and their in-silico analysis

  2018cites this paper
• 2 DNA Methylation and Histone Modifications in Patients With Cancer Potential Prognostic and Therapeutic Targets

  2018cites this paper
• Targeting of Epigenetic Modifier EZH2 in Oropharyngeal Squamous Cell Carcinomas

  2018cites this paper
• General discussion and future perspective

  2018cites this paper
• Prognostic and clinicopathological value of p16 protein aberrant expression in colorectal cancer

  2018cites this paper
• Promoter hypermethylation inactivate tumor suppressor FAM134B and is associated with poor prognosis in colorectal cancer

  2018cites this paper
• Environmental Exposures, the Epigenome, and African American Women’s Health

  2018cites this paper
• Gene Regulatory Networks: A Primer in Biological Processes and Statistical Modelling.

  2018cites this paper
• A modified bisulfite conversion method for the detection of DNA methylation.

  2017cites this paper
• Genetic and epigenetic aberrations of p16 in feline primary neoplastic diseases and tumor cell lines of lymphoid and non-lymphoid origins.

  2017cites this paper
• Molecular‐targeting therapies against quantitative abnormalities in gene expression with malignant tumors

  2017cites this paper
• Doxycycline-Regulated p16MTS1 Expression Suppresses the Anchorage-Independence and Tumorigenicity of Breast Cancer Cell Lines that Lack Endogenous p16

  2017cites this paper
• DNA and Histone Modifications in Cancer Diagnosis

  2017cites this paper
• Designing Epigenome Editing Tools to Understand the Functional Role of DNA Methylation Changes in Cancer

  2017influential citation
• Prognostic significance of p16INK4a alteration in soft tissue sarcomas: A meta-analysis.

  2017cites this paper
• Fast and precise detection of DNA methylation with tetramethylammonium-filled nanopore

  2017cites this paper
• 2 DNA Methylation and Histone Modifications in Patients With Cancer Potential Prognostic and Therapeutic Targets

  2017cites this paper
• Epigenetic Basis of Twin Discordance in Diseases: Future Benefits

  2017cites this paper
• Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma.

  2016cites this paper
• Title Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia

  2016cites this paper
• Tècniques de diagnòstic molecular aplicades a l'estudi del càncer

  2016cites this paper
• Spatial Dependency in Methylation Data

  2016cites this paper
• Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation

  2016cites this paper
• Gastric cancer development after the successful eradication of Helicobacter pylori.

  2016cites this paper
• Studies to Investigate Epigenetic Factors in Acute Myeloid Leukaemia

  2016cites this paper
• DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands.

  2016cites this paper
• Mutations in regulators of the epigenome and their effects on the DNA methylome

  2016cites this paper
• A Novel Algorithm for CpG Island Detection in Human Genome Based on Clustering and Chaotic Particle Swarm Optimization

  2016cites this paper
• Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia

  2016cites this paper
• Constitutional epimutation as a mechanism for cancer causality and heritability?

  2015cites this paper
• Epigenetics and Lymphoma: Can We Use Epigenetics to Prime or Reset Chemoresistant Lymphoma Programs?

  2015cites this paper
• ChIP-BS-Sequencing in Cancer Epigenomics

  2015cites this paper
• The potential for epigenetic analysis of paediatric CNS tumours to improve diagnosis, treatment and prognosis.

  2015cites this paper
• Promoter hypermethylation as a biomarker in prostate adenocarcinoma.

  2015cites this paper
• DNA methylation of tumor-suppressor miRNA genes in chronic lymphocytic leukemia.

  2015cites this paper
• DNA METHYLATION IN EXON 1 OF CDKN2A GENE IN FORMALIN-FIXED, PARAFFIN-EMBEDDED COLON CANCER SAMPLES

  2015cites this paper
• Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer

  2015cites this paper
• Molecular markers in development, diagnosis and progression of nonmuscle invasive bladder cancer

  2015influential citation
• Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma

  2015cites this paper
• Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells.

  2015cites this paper
• Epigenetic Changes in Aging and Age-related Disease

  2015cites this paper
• DNA Methylation Dynamics During Differentiation, Proliferation, and Tumorigenesis in the Intestinal Tract

  2015cites this paper
• Pertinence de la prise en compte des réponses épigénétiques chez des organismes chroniquement exposés à de faibles niveaux de substances radioactives

  2015cites this paper
• P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study

  2015cites this paper
• Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone

  2015cites this paper
• Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

  2015cites this paper
• Wilms' tumor gene 1 in different types of cancer

  2015cites this paper
• Deacetylase inhibitors for the treatment of myelodysplastic syndromes

  2015cites this paper
• P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

  2015cites this paper
• Epigenetic regulation by G protein alpha12 in human cancer cells and vascular endothelial cells

  2015cites this paper
• The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies

  2014cites this paper
• The epigenetic regulation of the EGF-receptor ligands Amphiregulin and Epiregulin and its impact on the outcome of EGFR-targeted therapies

  2014cites this paper
• Homeostatic Maintenance of Allele-Specific p16 Methylation in Cancer Cells Accompanied by Dynamic Focal Methylation and Hydroxymethylation

  2014cites this paper
• Distinct susceptibility of induction of methylation of p16ink4a and p19arf CpG islands by X-radiation and chemical carcinogen in mice.

  2014cites this paper
• The effect of diet on the intestinal epigenome.

  2014cites this paper
• MicroRNA and Drug Delivery

  2014cites this paper
• Relationships Between p16 Gene Promoter Methylation and Clinicopathologic Features of Colorectal Cancer: A Meta-Analysis of 27 Cohort Studies

  2014cites this paper
• Label-free fluorescence detection of DNA methylation and methyltransferase activity based on restriction endonuclease HpaII and exonuclease III.

  2014cites this paper
• Regulatory roles of microRNA-708 and microRNA-31 in proliferation, apoptosis and invasion of colorectal cancer cells

  2014cites this paper
• Sensitive colorimetric biosensing for methylation analysis of p16/CDKN2 promoter with hyperbranched rolling circle amplification.

  2014cites this paper