Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Molecular and Cellular Biology

• Publication date

  1995-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.15.3.1573PMID 7862150PMCID PMC230381
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1994influential reference
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