Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development

Our sophisticated thoughts and behaviors are based on the miraculous development of our complex nervous network system, in which many different types of proteins and signaling cascades are regulated in a temporally and spatially ordered manner. Here we review our recent attempts to grasp the principles of nervous system development in terms of general cellular phenomena and molecules, such as volume-regulated anion channels, intracellular Ca2+ and cyclic nucleotide signaling, the Npas4 transcription factor and the FLRT family of axon guidance molecules. We also present an example illustrating that the same FLRT family may regulate the development of vascular networks as well. The aim of this review is to open up new vistas for understanding the intricacy of nervous and vascular system development.

• Publication year

  2015

• Venue

  Journal of Physiological Sciences

• Publication date

  2015-10-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12576-015-0416-1PMID 26507418PMCID 4752580
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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