Cardiomyocytes Obtained From Induced Pluripotent Stem Cells With Long-QT Syndrome 3 Recapitulate Typical Disease-Specific Features In Vitro

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Circulation Research

• Publication date

  2011-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.111.243139PMID 21799153
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mouse Models of SCN5A-Related Cardiac Arrhythmias

  2012cited by this paper
• Modelling the long QT syndrome with induced pluripotent stem cells

  2011cited by this paper
• Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

  2010cited by this paper
• The genetic basis of long QT and short QT syndromes: A mutation update

  2009cited by this paper
• Mouse models of SCN5A-related cardiac arrhythmias.

  2008cited by this paper
• The ground state of embryonic stem cell self-renewal

  2008cited by this paper
• Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells

  2008cited by this paper
• Long‐QT syndrome‐related sodium channel mutations probed by the dynamic action potential clamp technique

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Identification and characterization of embryonic stem cell‐derived pacemaker and atrial cardiomyocytes

  2005cited by this paper
• Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome

  2001cited by this paper
• Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.

  1998cited by this paper
• Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells.

  1998cited by this paper
• Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

  1995cited by this paper
• Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.

  1994cited by this paper

• Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium–glucose cotransporter 2 inhibitors

  2024influential citation
• A Novel Recombinant Vitronectin Variant Supports the Expansion and Differentiation of Pluripotent Stem Cells in Defined Animal-Free Workflows

  2024cites this paper
• Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction

  2023cites this paper
• Proof of concept for monoclonal antibody therapy in a cellular model of acquired long QT syndrome type 3

  2023cites this paper
• Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

  2021influential citation
• Human iPSCs and their uses in developmental toxicology

  2021cites this paper
• Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation

  2021cites this paper
• Ion channel expression and electrophysiology of singular human (primary and induced pluripotent stem cell derived) cardiomyocytes

  2021cites this paper
• Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes

  2021cites this paper
• Development of Diagnostic and Therapeutic Strategy for Long QT Syndrome Using Human Induced Pluripotent Stem Cell Models

  2021cites this paper
• Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation

  2020cites this paper
• The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic Diseases

  2020cites this paper
• Arrhythmia mechanisms in human induced pluripotent stem cell-derived cardiomyocytes.

  2020cites this paper
• Dynamic clamp in electrophysiological studies on stem cell-derived cardiomyocytes-why and how?

  2020cites this paper
• Heritable arrhythmias associated with abnormal function of cardiac potassium channels.

  2020cites this paper
• Angiotensin II induces apoptosis in human induced pluripotent stem cell-derived cardiomyocytes

  2020cites this paper
• Quantification of Stem Cell Derived Cardiomyocyte Beating Mechanics using Video Microscopy Image Analysis

  2019cites this paper
• Long QT Syndrome: Genetics and Future Perspective

  2019cites this paper
• Cardiac Repolarization and Stem Cells: An Emerging Path Toward Precision Medicine

  2019cites this paper
• Human Induced Pluripotent Stem Cells as Platform for Functional Examination of Cardiovascular Genetics in a Dish

  2019cites this paper
• Prolonged post-differentiation culture influences the expression and biophysics of Na+ and Ca2+ channels in induced pluripotent stem cell-derived ventricular-like cardiomyocytes

  2019cites this paper
• MicroRNAs: Important Regulators of Induced Pluripotent Stem Cell Generation and Differentiation

  2018cites this paper
• Long and Short QT Syndromes

  2018cites this paper
• Mutations and Modifier Genes: Everything that Governs Congenital Long Qt Syndrome

  2018cites this paper
• Cardiac Sodium Channel (Dys)Function and Inherited Arrhythmia Syndromes

  2018cites this paper
• Prevalence and Pathogenesis of Dilated Cardiomyopathy

  2017cites this paper
• Combining hiPSC and CRISPR/Cas9 technologies for studying cardiac disease and development

  2017cites this paper
• Murine Electrophysiological Models of Cardiac Arrhythmogenesis.

  2017cites this paper
• Functional analysis of cardiomyocytes carrying mutations in SCN5A gene

  2017cites this paper
• Dilated Cardiomyopathy: Genetic Determinants and Mechanisms

  2017cites this paper
• Induced Pluripotent Stem Cells: Global Research Trends

  2017cites this paper
• Characterization of a Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for the Study of Variant Pathogenicity: Validation of a KCNJ2 Mutation

  2017cites this paper
• Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes

  2017cites this paper
• Puesta al dı́a : Innovación en cardiologı́a ( III ) Medicina personalizada : diagnóstico genético de cardiopatı́as / canalopatı́as hereditarias

  2017cites this paper
• Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative.

  2017cites this paper
• Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density

  2017cites this paper
• Role of miR-1305 in regulating pluripotency, cell cycle and apoptosis in human embryonic stem cells

  2016cites this paper
• Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction

  2016cites this paper
• Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes.

  2016cites this paper
• Patient-Derived Induced Pluripotent Stem Cells Provide a Regenerative Medicine Platform for Duchenne Muscular Dystrophy Heart Failure

  2016cites this paper
• Human derived cardiomyocytes: A decade of knowledge after the discovery of induced pluripotent stem cells

  2016influential citation
• Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome

  2016cites this paper
• Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function

  2016cites this paper
• Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling

  2016cites this paper
• Induced pluripotent stem cell and their applications inDrug Discovery and Precision Personalized Medicine

  2015cites this paper
• Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease

  2015cites this paper
• Myocardial Reprogramming Medicine : The Development , Application , and Challenge of Induced Pluripotent Stem Cells

  2015cites this paper
• Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy

  2015cites this paper
• RNA interference-based therapeutics for inherited long QT syndrome.

  2015cites this paper
• Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations

  2015cites this paper
• A two-scale map of global gene expression for characterising in vitro engineered cells

  2015cites this paper
• Diogo Gonçalves Biagi dos Santos

  2015cites this paper
• Functional Characterization of in vitro Models of Stem Cell-Derived Cardiomyocytes

  2015cites this paper
• Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration

  2015cites this paper
• Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes

  2015cites this paper
• Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters

  2015cites this paper
• Stem Cell–Derived Nodal-Like Cardiomyocytes as a Novel Pharmacologic Tool: Insights from Sinoatrial Node Development and Function

  2015cites this paper
• 先天性心疾患における不死化B細胞株由来induced pluripotent stem（iPS）細胞の樹立

  2015cites this paper
• Induced pluripotent stem cell-based therapies for inherited arrhythmias: opportunities and challenges involved (Review).

  2015cites this paper
• Induced pluripotent stem cell and their applications in Drug Discovery and Precision Personalized Medicine

  2015cites this paper
• An In Vitro Model of Early- or No-Reperfusion Scars to Explain Reentrant Arrhythmia Characteristics May Relate to Therapeutic Efficacy

  2015cites this paper
• Patch clamp apply in cardiomyocytes derived from patient's iPS cells for individual anticancer therapy.

  2014cites this paper
• A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes.

  2014cites this paper
• Functional and Pharmacological Analysis of Cardiomyocytes Differentiated from Human Peripheral Blood Mononuclear-Derived Pluripotent Stem Cells

  2014influential citation
• Human induced pluripotent stem cell for modeling cardiovascular diseases

  2014cites this paper
• Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling

  2014cites this paper
• Generation and Characterization of Functional Cardiomyocytes Derived from Human T Cell-Derived Induced Pluripotent Stem Cells

  2014cites this paper
• Optogenetic activation of Gq signalling modulates pacemaker activity of cardiomyocytes.

  2014cites this paper
• New iPSC for old long QT syndrome modeling: Putting the evidence into perspective

  2014cites this paper
• Induced pluripotent stem cells for regenerative medicine.

  2014cites this paper
• 93 – Long and Short QT Syndromes

  2014cites this paper
• Cardiac Sodium Channel Overlap Syndrome

  2014cites this paper
• Cardiac Myocyte Contraction Sustaining Enhancing Factor Predicted from Cardiac Stem Cell Research

  2014cites this paper
• Genetic Variants and Risk in Sudden Cardiac Death Syndromes

  2014cites this paper
• Myocardial Reprogramming Medicine: The Development, Application, and Challenge of Induced Pluripotent Stem Cells

  2014cites this paper
• Modelling genetic heart diseases with patient-specific induced pluripotent stem cells

  2014cites this paper
• Cardiac tissue engineering: renewing the arsenal for the battle against heart disease.

  2014cites this paper
• iPCS Cell Modeling of Inherited Cardiac Arrhythmias

  2014cites this paper
• Mutant Cardiac Sodium Channel Dysfunction Associated with Cardiomyopathy

  2014cites this paper
• Personalized medicine: genetic diagnosis for inherited cardiomyopathies/channelopathies.

  2013cites this paper
• Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome

  2013cites this paper
• Induced Pluripotent Stem Cells and Their Potential for Basic and Clinical Sciences

  2013cites this paper
• Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening

  2013cites this paper
• Res Induced Pluripotent Stem Cell Models for Arrhythmias Induced Pluripotent Stem Cell–Derived Cardiomyocytes Boutique Science or Valuable Arrhythmia

  2013cites this paper
• Current status of induced pluripotent stem cells in cardiac tissue regeneration and engineering

  2013cites this paper
• Chemical genetics and its potential in cardiac stem cell therapy

  2013influential citation
• Circulation Research Thematic Synopsis: Cardiovascular Genetics

  2013cites this paper
• Circulation Research Thematic Synopsis: Cellular Reprogramming & Induced Pluripotent Stem Cells

  2013cites this paper
• Modelling Human Channelopathies Using Induced Pluripotent Stem Cells: A Comprehensive Review

  2013cites this paper
• Lentiviral Vector Mediated Thymidine Kinase Expression in Pluripotent Stem Cells Enables Removal of Tumorigenic Cells

  2013cites this paper
• Recent advances in cardiac myocyte biology and function.

  2013cites this paper
• The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

  2013cites this paper
• The Disease-Specific Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Two Long QT Syndrome Type 3 Patients

  2013cites this paper
• 3D-Culture System for Heart Regeneration and Cardiac Medicine

  2013cites this paper
• Comparative gene expression profiling in human-induced pluripotent stem cell--derived cardiocytes and human and cynomolgus heart tissue.

  2013cites this paper
• Circulation Research Thematic Synopsis Cardiovascular Genetics The Editors

  2013cites this paper
• Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies

  2013cites this paper
• Induced Pluripotent Stem Cell Models for Arrhythmias Induced Pluripotent Stem Cell – Derived Cardiomyocytes

  2013cites this paper
• Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart.

  2013cites this paper
• Directing Cardiomyogenic Differentiation of Human Pluripotent Stem Cells by Plasmid-Based Transient Overexpression of Cardiac Transcription Factors

  2013cites this paper