Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2009-11-17

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1073/pnas.0905998106PMID 19901335PMCID PMC2780804
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo.

  2010cited by this paper
• Micro- and macrorheology of mucus.

  2009cited by this paper
• Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus.

  2009influential reference
• The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

  2009cited by this paper
• Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale

  2009cited by this paper
• Drug delivery: Stealth particles give mucus the slip.

  2009cited by this paper
• Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

  2009cited by this paper
• Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.

  2008cited by this paper
• Development of bioadhesive amino-pegylated poly(anhydride) nanoparticles designed for oral DNA delivery

  2008cited by this paper
• Development of bioadhesive amino-pegylated poly(anhydride) nanoparticles designed for oral DNA delivery.

  2008cited by this paper
• Quantifying the Intracellular Transport of Viral and Nonviral Gene Vectors in Primary Neurons

  2007cited by this paper
• Evaluation of bioadhesive potential and intestinal transport of pegylated poly(anhydride) nanoparticles.

  2007cited by this paper
• Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

  2007cited by this paper
• Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.

  2006cited by this paper
• Airway mucus: From production to secretion.

  2006cited by this paper
• Effect of reproductive status on uptake of latex microparticles in rat small intestine.

  2005cited by this paper
• Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): preparation and evaluation of their bioadhesive properties.

  2005cited by this paper
• The Expanding Role of Aerosols in Systemic Drug Delivery, Gene Therapy, and Vaccination

  2005cited by this paper
• Real-time multiple-particle tracking: applications to drug and gene delivery.

  2005cited by this paper
• Designing materials for biology and medicine

  2004cited by this paper
• Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for controlled drug delivery

  2004cited by this paper
• Drug Delivery Systems: Entering the Mainstream

  2004cited by this paper
• Transport of Polymeric Nanoparticle Gene Carriers in Gastric Mucus

  2004cited by this paper
• Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs.

  2004cited by this paper
• A Self-Sampling Method to Obtain Large Volumes of Undiluted Cervicovaginal Secretions

  2003cited by this paper
• Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease.

  2003cited by this paper
• Airway Retention of Materials of Different Solubility following Local Intrabronchial Deposition in Dogs

  2003cited by this paper
• Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport*

  2003cited by this paper
• Effect of pegylation on pharmaceuticals

  2003cited by this paper
• Pharmaceutical and biotechnological aerosols for cystic fibrosis therapy.

  2002cited by this paper
• Polyanhydrides: an overview.

  2002cited by this paper
• Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport

  2002cited by this paper
• Mucus clearance as a primary innate defense mechanism for mammalian airways.

  2002cited by this paper
• New polymeric carriers for controlled drug delivery following inhalation or injection.

  2002cited by this paper
• Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir.

  2001cited by this paper
• Diffusion of macromolecules and virus-like particles in human cervical mucus.

  2001cited by this paper
• Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium

  2001cited by this paper
• Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release

  1999cited by this paper
• Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease.

  1998cited by this paper
• Single-particle tracking: the distribution of diffusion coefficients.

  1997cited by this paper
• Biologically erodable microspheres as potential oral drug delivery systems

  1997cited by this paper
• Biodegradable long-circulating polymeric nanospheres.

  1994cited by this paper
• Rat sperm are mechanically immobilized in the caudal epididymis by "immobilin," a high molecular weight glycoprotein.

  1983cited by this paper
• Deposition, retention, and clearance of inhaled particles.

  1980cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Amount of MUC5B Mucin in Cervical Mucus Peaks at Midcycle*

  year unknowncited by this paper

• Development of nanoparticle-based Toll-like receptor agonists for respiratory immunotherapy

  2026cites this paper
• Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation

  2026cites this paper
• siRNA-based nanotherapeutics for malignant and non-malignant diffuse parenchymal lung diseases

  2026cites this paper
• MIXED MICELLES: ADVANCED NANOCARRIERS FOR PULMONARY MUCOLYTIC DRUG DELIVERY-A SYSTEMATIC SCOPING REVIEW

  2026cites this paper
• Mucosal Wound Repair: Reinforcement of Respiratory Mucus Barrier Function by Inorganic Polyphosphate.

  2026cites this paper
• Gastrointestinal distribution of engineered biodegradable urease-powered nanomotors.

  2025cites this paper
• Oral Delivery Systems of Dietary Bioactive Compounds Based on Metal-Organic Frameworks: A Review.

  2025cites this paper
• Advancing Inflammatory Bowel Disease Treatment by Targeting the Innate Immune System and Precision Drug Delivery

  2025cites this paper
• Improved oral bioavailability of paclitaxel through folate-engineered zein nanoparticles: Evaluation in intestinal organoid and in vivo models.

  2025cites this paper
• Oral administration amifostine-grafted chitosan nanodrug for intestinal radioprotection.

  2025cites this paper
• Advances in polymeric nanoparticles for oral drug delivery: mechanisms, challenges, emerging trends, and preclinical to clinical perspectives

  2025cites this paper
• Solvation-Layer Mediated Interfacial Assembly for Surface Topological Engineering of Mesoporous Microcarriers.

  2025cites this paper
• Boronic acid-mediated mucin/surface interactions of zwitterionic polymer brushes.

  2025cites this paper
• Intravaginal co-delivery of myoinositol and metformin via dual MPPs-loaded gel for PCOS amelioration: an in-vivo study in a rat model

  2025cites this paper
• The Role of Nanoparticle Elasticity on Biological Hydrogel Penetration

  2025cites this paper
• Inhalable materials and biologics for lung defence and drug delivery

  2025cites this paper
• Surface Chemistry-Driven Permeation of Nanoparticles Produced by Flash Nanoprecipitation through Mucus Barriers.

  2025cites this paper
• Anti-Candida Activity of Cysteine-Modified Amidated Decoralin in the Presence of Engineered Nanomaterials

  2025cites this paper
• Diffusion of Nanorods with Various Lengths and Rigidities in Cross-Linked Networks

  2025cites this paper
• Nano Micelles: The Tiny Titans of Targeted Therapy

  2025cites this paper
• Mechanism of charge self-reversal nano-nutrient delivery system to overcome the mucosal barrier

  2024cites this paper
• Dasatinib loaded mucoadhesive lecithin-chitosan hybrid nanoparticles for its augmented oral delivery, in-vitro efficacy and safety.

  2024cites this paper
• Understanding Mucosal Physiology and Rationale of Formulation Design for Improved Mucosal Immunity.

  2024cites this paper
• Synthesis and Evaluation of Boronated 4‐Arm Polyethylene Glycol for Application in Transmucosal Drug Delivery

  2024cites this paper
• A REVIEW ON DEVELOPMENT OF COLON TARGETED DRUG DELIVERY SYSTEM

  2024cites this paper
• Pulmonary RNA Interference against Acute Lung Injury Mediated by Mucus- and Cell-penetrating Nanocomplexes.

  2024cites this paper
• Preparation of Ibuprofen-Loaded Inhalable γCD-MOFs by Freeze-Drying Using the QbD Approach

  2024influential citation
• In vitro screening of potential echinochrome delivery systems for the treatment of eye diseases

  2024cites this paper
• In situ pulmonary mucus hydration assay using rotational and translational diffusion of gold nanorods with polarization-sensitive optical coherence tomography

  2024cites this paper
• Mucoadhesion across scales: Towards the design of protein-based adhesives.

  2024cites this paper
• Highly distinctive linear and nonlinear rheological behaviors of mucin-based protein solutions as simulated normal and asthmatic human airway mucus

  2024cites this paper
• A journey through the history of PEGylated drug delivery nanocarriers

  2024cites this paper
• Transepithelial transport of nanoparticles in oral drug delivery: From the perspective of surface and holistic property modulation

  2024cites this paper
• Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2.

  2023cites this paper
• Nanoparticle-based platforms for targeted drug delivery to the pulmonary system as therapeutics to curb cystic fibrosis: A review.

  2023cites this paper
• Oral docetaxel delivery with cationic polymeric core-shell nanocapsules: In vitro and in vivo evaluation

  2023cites this paper
• Micro and nano-carriers-based pulmonary drug delivery system: Their current updates, challenges, and limitations – A review

  2023cites this paper
• Preparation and Characterization of Ibuprofen Containing Nano-Embedded-Microparticles for Pulmonary Delivery

  2023cites this paper
• Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy.

  2023cites this paper
• Inhaled RNA drugs to treat lung diseases: Disease-related cells and nano-bio interactions.

  2023cites this paper
• Nanoparticle oral absorption and its clinical translational potential.

  2023cites this paper
• Vaginal Drug Delivery Systems to Control Microbe-Associated Infections.

  2023cites this paper
• Investigation of Physico-Chemical Stability and Aerodynamic Properties of Novel “Nano-in-Micro” Structured Dry Powder Inhaler System

  2023cites this paper
• pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue.

  2023cites this paper
• PLGA: A Wow Smart Biodegradable Polymer in Drug Delivery System

  2023cites this paper
• Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems

  2023cites this paper
• Challenges and opportunities in delivering oral peptides and proteins

  2023cites this paper
• Mucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments.

  2023cites this paper
• Oral nanoparticulate drug delivery systems for the treatment of intestinal bowel disease and colorectal cancer

  2023cites this paper
• Expanding opportunities to engineer mucosal vaccination with biomaterials.

  2023cites this paper
• Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa,

  2023cites this paper
• Design and Development of Ornidazole Loaded Polymeric Nanoparticles

  2022cites this paper
• Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

  2022influential citation
• Lipid-Based Nanocarriers for Oral Delivery of Proteins and Peptides: Opportunities, Challenges, and Future Prospects

  2022cites this paper
• Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

  2022cites this paper
• Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils

  2022influential citation
• Giving Drugs a Second Chance: Antibacterial and Antibiofilm Effects of Ciclopirox and Ribavirin against Cystic Fibrosis Pseudomonas aeruginosa Strains

  2022cites this paper
• Mucus-permeable polymyxin B-hyaluronic acid/ poly (lactic-co-glycolic acid) nanoparticle platform for the nebulized treatment of lung infections.

  2022cites this paper
• Recent advances on drug delivery applications of mucopenetrative/mucoadhesive particles: A review

  2022cites this paper
• TLR7 agonist loaded airway epithelial targeting nanoparticles stimulate innate immunity and suppress viral replication in human bronchial epithelial cells.

  2022cites this paper
• Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020.

  2022cites this paper
• Controlled release and targeted drug delivery with poly(lactic-co-glycolic acid) nanoparticles: reviewing two decades of research

  2022cites this paper
• Advances in the Treatment of Inflammatory Bowel Disease: Focus on Polysaccharide Nanoparticulate Drug Delivery Systems.

  2022cites this paper
• High Drug Loading Nanosized Amorphous Solid Dispersion (NASD) with Enhanced in vitro Solubility and Permeability: Benchmarking conventional ASD.

  2022cites this paper
• Recent advances of polymer based nanosystems in cancer management

  2022cites this paper
• Pulmonary Delivery Nanomedicines Towards Circumventing Physiological Barriers: Strategies and Characterization Approaches.

  2022cites this paper
• Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

  2022cites this paper
• Dynamics of self-propelled tracer particles inside a polymer network.

  2022cites this paper
• Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring

  2021cites this paper
• Selective uptake into inflamed human intestinal tissue and immune cell targeting by wormlike polymer micelles

  2021cites this paper
• Size-dependent biodistribution of thiol-organosilica nanoparticles and F4/80 protein expression in the genital tract of female mice after intravaginal administration

  2021cites this paper
• Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections

  2021cites this paper
• Insulin nanoformulations for nonparenteral administration in diabetic patients

  2021cites this paper
• A Two‐Pronged Pulmonary Gene Delivery Strategy: A Surface‐Modified Fullerene Nanoparticle and a Hypotonic Vehicle

  2021cites this paper
• Oral drug delivery of nanomedicine

  2021cites this paper
• Chitosan Nanoparticles Facilitate Improved Intestinal Permeation and Oral Pharmacokinetics of the Mast Cell Stabiliser Cromoglycate.

  2021cites this paper
• KPI-121 0.25%: A New Option for the Treatment of Dry Eye Disease

  2021cites this paper
• An Insight into the Polymeric Nanoparticles Applications in Diabetes Diagnosis and Treatment.

  2021cites this paper
• Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art

  2021cites this paper
• Computer Modeling of Aerosol Particle Transport through Lung Mucosa

  2021cites this paper
• Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

  2021cites this paper
• Polymer nanoparticles-preparations, applications and future insights: a concise review

  2021cites this paper
• Polymeric nanotherapeutics acting at special regions of body

  2021cites this paper
• Chain stiffness boosts active nanoparticle transport in polymer networks.

  2021cites this paper
• Multifunctional Lipid-Based Nanoparticles for Codelivery of Anticancer Drugs and siRNA for Treatment of Non-Small Cell Lung Cancer with Different Level of Resistance and EGFR Mutations

  2021cites this paper
• Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

  2021cites this paper
• Bioinspired particle engineering for non-invasive inhaled drug delivery to the lungs.

  2021cites this paper
• Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

  2021cites this paper
• Nanomicelles: Types, properties and applications in drug delivery

  2021cites this paper
• Nanomedicine for vaginal drug delivery

  2021cites this paper
• Pro‐Peptide‐Reinforced, Mucus‐Penetrating Pulmonary siRNA Delivery Mitigates Cytokine Storm in Pneumonia

  2021cites this paper
• The role of KPI-121 0.25% in the treatment of dry eye disease: penetrating the mucus barrier to treat periodic flares

  2021cites this paper
• An ex Vivo Model Enables Systematic Investigation of the Intestinal Absorption and Transcytosis of Oral Particulate Nanocarriers.

  2021cites this paper
• The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis.

  2021cites this paper
• Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis

  2020cites this paper
• Application of Nanomaterials in Treatment of Endocrine Diseases

  2020cites this paper
• Enhancing nanoparticle penetration through airway mucus to improve drug delivery efficacy in the lung

  2020cites this paper
• Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals

  2020cites this paper
• New advances in insulin products

  2020cites this paper
• Developing inhaled protein therapeutics for lung diseases

  2020cites this paper