Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  International Journal of Molecular Medicine

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/ijmm.2011.749PMID 21769418
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone

  2011cited by this paper
• Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation.

  2010influential reference
• Functions of nuclear factor κB in bone

  2010cited by this paper
• Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice.

  2010cited by this paper
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  2010cited by this paper
• Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats.

  2010cited by this paper
• Inhibition of Osteoblast Functions by IKK/NF-κB in Osteoporosis

  2009cited by this paper
• The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblasts.

  2009cited by this paper
• Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF

  2009cited by this paper
• The estrogen 17beta-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-kappaB activity.

  2009cited by this paper
• The bone anabolic carotenoid beta-cryptoxanthin enhances transforming growth factor-beta1-induced SMAD activation in MC3T3 preosteoblasts.

  2009cited by this paper
• The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts

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• Suppression of NF-kappaB activation blocks osteoclastic bone resorption during estrogen deficiency.

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro

  2007influential reference
• Endogenous TNFα Lowers Maximum Peak Bone Mass and Inhibits Osteoblastic Smad Activation Through NF‐κB

  2007cited by this paper
• Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated

  2007cited by this paper
• Quercetin, a bioflavonoid, accelerates TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells.

  2006cited by this paper
• Naturally occurring NF-kappaB inhibitors.

  2006cited by this paper
• Estrogen deficiency and bone loss: an inflammatory tale.

  2006influential reference
• Transforming growth factor-beta1 to the bone.

  2005cited by this paper
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  2003cited by this paper
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  2000cited by this paper
• The estrogen 17β-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-κB activity

  1998cited by this paper
• Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

  1997cited by this paper
• 0163-769X/03/$20.00/0 Endocrine Reviews 24(2):218–235 Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/er.2002-0023 Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton

  year unknowncited by this paper

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