Leptin's neuroprotective action in experimental transient ischemic damage of the gerbil hippocampus is linked to altered leptin receptor immunoreactivity.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Neurological Sciences

• Publication date

  2011-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jns.2010.12.025PMID 21277586
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2010cited by this paper
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  2007influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1990cited by this paper
• Delayed neuronal death in the gerbil hippocampus following ischemia.

  1982cited by this paper
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  1974cited by this paper
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  year unknowncited by this paper
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