Interaction Between Helminths and Toll-Like Receptors: Possibilities and Potentials for Asthma Therapy

No abstract is available for this paper.

• Publication year

  2016

• Venue

  International Reviews of Immunology

• Publication date

  2016-04-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3109/08830185.2015.1096936PMID 27120222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Worms as therapeutic agents for allergy and asthma: understanding why benefits in animal studies have not translated into clinical success.

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• Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

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• The development and in vivo function of T helper 9 cells

  2015cited by this paper
• Toll-like receptor signaling in parasitic infections

  2015cited by this paper
• TLR2‐dependent amelioration of allergic airway inflammation by parasitic nematode type II MIF in mice

  2015cited by this paper
• Pathobiology of severe asthma.

  2015cited by this paper
• Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis*

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• Epicutaneous immune modulation with Bet v 1 plus R848 suppresses allergic asthma in a murine model

  2014cited by this paper
• Type 2 inflammation in asthma — present in most, absent in many

  2014cited by this paper
• Identification of anti-allergic effect of Clonorchis sinensis-derived protein venom allergen-like proteins (CsVAL).

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• The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages

  2014cited by this paper
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• Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy

  2014influential reference
• Regulation of anti-inflammatory cytokines IL-10 and TGF-β in mouse dendritic cells through treatment with Clonorchis sinensis crude antigen

  2014cited by this paper
• Activation of human basophils by combined toll‐like receptor‐ and FcεRI‐triggering can promote Th2 skewing of naive T helper cells

  2014cited by this paper
• Cellular targets of regulatory B cell-mediated suppression.

  2014cited by this paper
• Therapeutic potential of larval excretory/secretory proteins of the pig whipworm Trichuris suis in allergic disease

  2014cited by this paper
• Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.

  2014cited by this paper
• The immunology of asthma

  2014influential reference
• Effects of Toll-Like Receptor Stimulation on Eosinophilic Infiltration in Lungs of BALB/c Mice Immunized with UV-Inactivated Severe Acute Respiratory Syndrome-Related Coronavirus Vaccine

  2014cited by this paper
• Interleukin 10 (IL-10)-producing CD1dhi regulatory B cells from Schistosoma haematobium-infected individuals induce IL-10-positive T cells and suppress effector T-cell cytokines.

  2014cited by this paper
• CD24hiCD27+ B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

  2014cited by this paper
• IL-17 in severe asthma. Where do we stand?

  2014cited by this paper
• Proteomic Analysis of Adult Ascaris suum Fluid Compartments and Secretory Products

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• ES‐62 Protects Against Collagen‐Induced Arthritis by Resetting Interleukin‐22 Toward Resolution of Inflammation in the Joints

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• Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides

  2014cited by this paper
• TLR2- and 4-independent immunomodulatory effect of high molecular weight components from Ascaris suum.

  2014cited by this paper
• Development of a Novel Severe Triple Allergen Asthma Model in Mice Which Is Resistant to Dexamethasone and Partially Resistant to TLR7 and TLR9 Agonist Treatment

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• Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation

  2014cited by this paper
• Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

  2014cited by this paper
• Refractory asthma: mechanisms, targets, and therapy

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• Gene Silencing of SOCS3 by siRNA Intranasal Delivery Inhibits Asthma Phenotype in Mice

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• Fasciola hepatica Kunitz Type Molecule Decreases Dendritic Cell Activation and Their Ability to Induce Inflammatory Responses

  2014cited by this paper
• Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

  2014cited by this paper
• Filarial antigens mediate apoptosis of human monocytes through Toll-like receptor 4.

  2014cited by this paper
• Immunomodulation of ALT-2 and TLR may collude in antigen specific T cell hyporesponsiveness: Proposed mechanism for elevated IL-10 levels in Balb/C mice

  2014cited by this paper
• Effect of helminth-induced immunity on infections with microbial pathogens

  2013cited by this paper
• Fasciola hepatica tegumental coat antigen suppresses MAPK signalling in dendritic cells and up‐regulates the expression of SOCS3

  2013cited by this paper
• Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms.

  2013cited by this paper
• Natural Killer Cells in Asthma

  2013cited by this paper
• Autoimmunity: Will worms cure rheumatoid arthritis?

  2013cited by this paper
• Innate Immune Response of Alveolar Macrophage to House Dust Mite Allergen Is Mediated through TLR2/-4 Co-Activation

  2013cited by this paper
• Impact of worms and their products on eosinophils and neutrophils in experimental asthma.

  2013cited by this paper
• Toll-like receptor 7 rapidly relaxes human airways.

  2013cited by this paper
• The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma.

  2013cited by this paper
• Distinct Chemokine Receptor Axes Regulate Th9 Cell Trafficking to Allergic and Autoimmune Inflammatory Sites

  2013cited by this paper
• TLR2 Directing PD-L2 Expression Inhibit T Cells Response in Schistosoma japonicum Infection

  2013cited by this paper
• Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated.

  2013cited by this paper
• Helminth‐excreted/secreted products are recognized by multiple receptors on DCs to block the TLR response and bias Th2 polarization in a cRAF dependent pathway

  2013cited by this paper
• Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

  2013cited by this paper
• Innate immune cells in asthma.

  2013cited by this paper
• Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion

  2013cited by this paper
• A nematode immunomodulator suppresses grass pollen-specific allergic responses by controlling excessive Th2 inflammation.

  2013cited by this paper
• Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

  2013cited by this paper
• TLR-2 Activation Induces Regulatory T Cells and Long-Term Suppression of Asthma Manifestations in Mice

  2013cited by this paper
• Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection.

  2013cited by this paper
• Alternative activation of macrophages by filarial nematodes is MyD88-independent

  2013cited by this paper
• MHC Class II Expression in Human Basophils: Induction and Lack of Functional Significance

  2013cited by this paper
• Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists

  2013cited by this paper
• Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation: Role of TLR4 and TLR2

  2013cited by this paper
• TLR3, TLR4 and TLRs7–9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma

  2013cited by this paper
• Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

  2013influential reference
• Parasite Infections in Multiple Sclerosis Modulate Immune Responses through a Retinoic Acid–Dependent Pathway

  2013cited by this paper
• Asthma phenotypes: the evolution from clinical to molecular approaches

  2012cited by this paper
• TLR3 but Not TLR7/8 Ligand Induces Allergic Sensitization to Inhaled Allergen

  2012cited by this paper
• Chitohexaose Activates Macrophages by Alternate Pathway through TLR4 and Blocks Endotoxemia

  2012cited by this paper
• Innate and adaptive immune responses in asthma

  2012cited by this paper
• Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce Apoptosis and Tolerogenic Properties in Dendritic Cells In Vitro

  2012cited by this paper
• The potential of biologics for the treatment of asthma

  2012cited by this paper
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  2012cited by this paper
• Deficiency in TLR2 but not in TLR4 impairs dendritic cells derived IL-10 responses to schistosome antigens.

  2012cited by this paper
• Pathogenesis of severe asthma

  2012cited by this paper
• Risk Factors for Asthma in a Helminth Endemic Area in Bahia, Brazil

  2012cited by this paper
• The airway epithelium in asthma

  2012cited by this paper
• Hymenolepis diminuta: analysis of the expression of Toll-like receptor genes (TLR2 and TLR4) in the small and large intestines of rats.

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• The TLR5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens

  2012cited by this paper
• The TLR7 Agonist R848 Alleviates Allergic Inflammation by Targeting Invariant NKT Cells To Produce IFN-γ

  2011cited by this paper
• Regulatory B Cells and Allergic Diseases

  2011cited by this paper
• Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.

  2011influential reference
• The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.

  2011cited by this paper
• Th17 cells: new players in asthma pathogenesis

  2011cited by this paper
• Immune response in symptomatic and asymptomatic neurocysticercosis

  2011cited by this paper
• Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen

  2011cited by this paper
• A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides

  2011cited by this paper
• The genetics of asthma and allergic disease: a 21st century perspective

  2011influential reference
• T regulatory cells in childhood asthma.

  2011cited by this paper
• The toll-like receptor (TLR) 5 ligand, flagellin, prometes asthma by priming allergic responses to indoor allergens

  2011cited by this paper
• The role of innate immunity activation in house dust mite allergy.

  2011cited by this paper
• TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure.

  2011cited by this paper
• A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

  2011cited by this paper
• Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program.

  2011cited by this paper
• TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL‐10

  2011cited by this paper
• Toll-like receptor modulators: a patent review (2006 – 2010)

  2011cited by this paper
• Defeating sepsis by misleading MyD88

  2011cited by this paper
• Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro

  2011cited by this paper
• TLR-based immune adjuvants.

  2011cited by this paper
• Toll-Like Receptor 2 and Muc2 Expression on Human Intestinal Epithelial Cells by Gymnophalloides seoi Adult Antigen

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• The many paths to asthma: phenotype shaped by innate and adaptive immunity

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• Antigens from the parasitic nematode Trichuris suis induce metabolic reprogramming and trained immunity to constrain inflammatory responses in macrophages.

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• Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection

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• Sulfur dioxide-induced exacerbation of airway inflammation via reactive oxygen species production and the toll-like receptor 4/nuclear factor-κB pathway in asthmatic mice

  2021cites this paper
• Establishing a high microbial load maternal-offspring asthma model in adult mice.

  2020cites this paper
• Effects of TLR agonists on immune responses in Trichinella spiralis infected mice

  2020cites this paper
• Helminth Induced Immunoregulation and Novel Therapeutic Avenue of Allergy

  2020cites this paper
• Immunomodulation by Helminths: Intracellular Pathways and Extracellular Vesicles

  2018cites this paper
• The impact of a helminth-modified microbiome on host immunity

  2018cites this paper
• Dual Role of Toll-like Receptors in Human and Experimental Asthma Models

  2018cites this paper
• Vaccine adjuvants: past, current and future

  2018cites this paper
• Parasites and asthma

  2017cites this paper
• Helminth-induced apoptosis: a silent strategy for immunosuppression

  2017influential citation
• Toll-like receptor-mediated involvement of innate immune cells in asthma disease.

  2017cites this paper
• Targeting Pattern Recognition Receptors (PRRs) in Nano- Adjuvants: Current Perspectives

  2016cites this paper