Kinetics of nitric oxide autoxidation in aqueous solution.

A kinetic study of the reaction of NO with O2 in aqueous solution has been carried out using a colorimetric method based on a pH indicator and a stopped-flow spectrophotometer. The reaction is second order in NO concentration and first order in O2 concentration; the overall third order rate constant is 6.3 (+/- 0.4) x 10(6) (M-1)2 s-1. Model calculations for the reaction at estimated physiological concentrations of NO and O2 indicate that the simple autoxidation of NO will not limit its diffusion from the site of production in endothelial cells to a spatially removed target molecule such as guanylate cyclase in myocytes and platelets.

• Publication year

  1994

• Venue

  Journal of Biological Chemistry

• Publication date

  1994-02-25

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/s0021-9258(17)37543-9PMID 8119931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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