Contributions of Wiskott–Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Immunological Reviews

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-065X.2009.00846.xPMID 19909364
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome.

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• The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis1

  2009influential reference
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• T cell antigen receptor signaling and immunological synapse stability require myosin IIA

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• Wiskott-Aldrich syndrome

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• Hierarchical regulation of WASP/WAVE proteins.

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• Evolution of Highly Polymorphic T Cell Populations in Siblings with the Wiskott-Aldrich Syndrome

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• Human Subtelomeric WASH Genes Encode a New Subclass of the WASP Family

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• Thymic development and peripheral homeostasis of regulatory T cells.

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• Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein.

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• Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2.

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• Regulation of actin filament assembly by Arp2/3 complex and formins.

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• Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells.

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• The Wiskott-Aldrich syndrome protein is required for the function of CD4+CD25+Foxp3+ regulatory T cells

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• Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

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• SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.

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• Wiskott–Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development

  2007influential reference
• Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.

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• Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia

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• The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

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• Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.

  2007influential reference
• Regulation of T-cell activation by the cytoskeleton

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• Capu and Spire Assemble a Cytoplasmic Actin Mesh that Maintains Microtubule Organization in the Drosophila Oocyte

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• Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

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• The WASP–WAVE protein network: connecting the membrane to the cytoskeleton

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