The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecules and Cells

• Publication date

  2014-08-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2014.06.016PMID 25042804PMCID PMC4245277
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
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  2011influential reference
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  2009influential reference
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  2004cited by this paper
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  2004cited by this paper
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  1991cited by this paper
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  1991cited by this paper

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