A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Thorax

• Publication date

  2014-07-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/thoraxjnl-2014-205091PMID 24990664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• APSR RESPIRATORY UPDATES

  2016cited by this paper
• Systematic identification of trans eQTLs as putative drivers of known disease associations

  2013cited by this paper
• Comprehensive Clinical and Molecular Analysis of 12 Families with Type 1 Recessive Cutis Laxa

  2013cited by this paper
• SMIM1 underlies the Vel blood group and influences red blood cell traits

  2013cited by this paper
• Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

  2013cited by this paper
• Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis.

  2012cited by this paper
• Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

  2012cited by this paper
• Molecular signature of smoking in human lung tissues.

  2012cited by this paper
• Small-airway obstruction and emphysema in chronic obstructive pulmonary disease.

  2011cited by this paper
• Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

  2011cited by this paper
• Is the aging process accelerated in chronic obstructive pulmonary disease?

  2011cited by this paper
• Hypothesis-driven Research On Genomic Data Derived From A Large Scale Lung EQTL Mapping Study

  2010cited by this paper
• COPD as a disease of accelerated lung aging.

  2009cited by this paper
• Molecular biomarkers for quantitative and discrete COPD phenotypes.

  2009cited by this paper
• COPD as a disease of accelerated lung aging(a).

  2009cited by this paper
• Elastin expression in very severe human COPD

  2009cited by this paper
• Fibulin-5, an integrin-binding matricellular protein: its function in development and disease

  2009cited by this paper
• TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen.

  2009cited by this paper
• The pathology of chronic obstructive pulmonary disease.

  2009cited by this paper
• Latent TGF-β-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly

  2008cited by this paper
• Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.

  2008cited by this paper
• Latent TGF‐β‐binding protein 2 binds to DANCE/fibulin‐5 and regulates elastic fiber assembly

  2007cited by this paper
• Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo

  2007cited by this paper
• Microfibril‐associated Protein 4 Binds to Surfactant Protein A (SP‐A) and Colocalizes with SP‐A in the Extracellular Matrix of the Lung

  2006cited by this paper
• Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity.

  2006cited by this paper
• Wnt signalling in lung development and diseases

  2006cited by this paper
• Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.

  2006cited by this paper
• The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

  2006cited by this paper
• Pathology of chronic obstructive pulmonary disease

  2006cited by this paper
• Vascular endothelial growth factor in the lung.

  2006cited by this paper
• Gene expression profiling of human lung tissue from smokers with severe emphysema.

  2004cited by this paper
• Emphysema lung tissue gene expression profiling.

  2004cited by this paper
• Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.

  2004cited by this paper
• Chronic obstructive pulmonary disease: molecular and cellularmechanisms

  2003cited by this paper
• Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair.

  2003cited by this paper
• Fibulin-5/DANCE is essential for elastogenesis in vivo

  2002cited by this paper
• Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo

  2002cited by this paper
• The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.

  1999cited by this paper
• Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium.

  1998cited by this paper
• Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency.

  1989cited by this paper

• Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish.

  2026cites this paper
• Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants

  2026cites this paper
• COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit.

  2025cites this paper
• Potential diagnostic markers and therapeutic targets for major depressive disorder based on bioinformatics analysis and molecular docking studies

  2025cites this paper
• Advances in Interleukin-6 Family Cytokines and the Role in Respiratory Diseases

  2025cites this paper
• Latent transforming growth factor binding protein-2 (LTBP2), an IPF biomarker of clinical decline, promotes TGF-beta signaling and lung fibrosis in mice

  2025cites this paper
• An active peptide from yak inhibits hypoxia-induced lung injury via suppressing VEGF/MAPK/inflammatory signaling

  2024cites this paper
• Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

  2024cites this paper
• Independent elevation of plasma fibulin-5 proceeding chronic hydrocephalus development after aneurysmal subarachnoid hemorrhage.

  2024cites this paper
• Microfibrillar-associated protein 4 as a predictive biomarker of treatment response in patients with chronic inflammatory diseases initiating biologics: secondary analyses based on the prospective BELIEVE cohort study

  2024cites this paper
• Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines

  2023influential citation
• Cellular and molecular mechanisms of fibrosis and resolution in bleomycin-induced pulmonary fibrosis mouse model revealed by spatial transcriptome analysis

  2023cites this paper
• The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease

  2023cites this paper
• Age-associated Differences in the Human Lung Extracellular Matrix.

  2023cites this paper
• Citrullination of matrisomal proteins in health and diseases

  2023cites this paper
• Identifying chronic obstructive pulmonary disease from integrative omics and clustering in lung tissue

  2023cites this paper
• Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

  2023cites this paper
• A proteomics approach to identify COPD-related changes in lung fibroblasts.

  2023cites this paper
• Genetic mechanisms of primary lung emphysema

  2022cites this paper
• MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish

  2022cites this paper
• Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.

  2022cites this paper
• Microfibrillar-associated protein 4 in health and disease.

  2022cites this paper
• Quality over quantity: the importance of collecting relevant samples to understand complex diseases

  2022cites this paper
• Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties

  2022cites this paper
• A transcriptomics-guided drug target discovery strategy identifies receptor ligands for lung regeneration

  2022cites this paper
• Transcriptome-based Signatures: The Future Biomarkers in Obstructive Pulmonary Diseases Such as Asthma and Chronic Obstructive Pulmonary Disease?

  2021cites this paper
• Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint

  2021cites this paper
• A transcriptomics-guided drug target discovery strategy identifies novel receptor ligands for lung regeneration

  2021cites this paper
• Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres

  2021cites this paper
• Therapeutic targets in lung tissue remodelling and fibrosis.

  2021cites this paper
• Therapeutic Targeting of IL-11 for Chronic Lung Disease.

  2021cites this paper
• Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples

  2021cites this paper
• The role of altered stem cell function in airway and alveolar repair and remodelling in COPD

  2021cites this paper
• Exploration of the Important Role of Microfibril-Associated Protein 4 Gene in Oral Squamous Cell Carcinoma

  2021cites this paper
• Bioreactors for Vocal Fold Tissue Engineering

  2021cites this paper
• Revealing consensus gene pathways associated with respiratory functions and disrupted by PM2.5 nitrate exposure at bulk tissue and single cell resolution.

  2021cites this paper
• A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

  2020cites this paper
• Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4

  2020cites this paper
• Genetic regulation of gene expression of MIF family members in lung tissue

  2020cites this paper
• Molecular structure and function of microfibrillar‐associated proteins in skeletal and metabolic disorders and cancers

  2020cites this paper
• COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins

  2020cites this paper
• Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scienti fi c Rationale

  2019influential citation
• Different effects of titanium dioxide nanoparticles instillation in young and adult mice on DNA methylation related with lung inflammation and fibrosis.

  2019cites this paper
• Chronic Lung Pathologies That Require Repair and Regeneration

  2019cites this paper
• Fibulin‐1 and fibulin‐5 as rule ‐out tests for non–ST ‐elevation myocardial infarction in the emergency setting

  2019cites this paper
• Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD

  2019cites this paper
• Preclinical Evidence for the Role of Stem/Stromal Cells in COPD

  2019cites this paper
• Identification of key pathways and genes in different types of chronic kidney disease based on WGCNA

  2019cites this paper
• Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale

  2019influential citation
• MicroRNAs as regulators of lung homeostasis, abnormal repair and ageing

  2019cites this paper
• Bioinformatics identification of potential genes and pathways in preeclampsia based on functional gene set enrichment analyses.

  2019cites this paper
• Genetic underpinnings of lung function and COPD

  2019cites this paper
• COPD_A_228411 2587..2602

  2019influential citation
• Epigenetic Profiles Reveal That ADCYAP1 Serves as Key Molecule in Gestational Diabetes Mellitus

  2019cites this paper
• Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts

  2019cites this paper
• High plasma microfibrillar-associated protein 4 is associated with reduced surgical repair in abdominal aortic aneurysms.

  2019cites this paper
• Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

  2019cites this paper
• High Expression Levels of AGGF1 and MFAP4 Predict Primary Platinum-Based Chemoresistance and are Associated with Adverse Prognosis in Patients with Serous Ovarian Cancer

  2019cites this paper
• Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers.

  2019cites this paper
• Emphysema: looking beyond alpha-1 antitrypsin deficiency

  2019cites this paper
• Understanding shared pathogenesis between chronic obstructive pulmonary disease (COPD) and lung cancer by means of cell specific genomics

  2018cites this paper
• Scarring vs. functional healing: Matrix‐based strategies to regulate tissue repair

  2018cites this paper
• Extracellular matrix in lung development, homeostasis and disease.

  2018cites this paper
• Matrix remodeling in chronic lung diseases.

  2018cites this paper
• Whole‐Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease

  2018cites this paper
• Copper as the most likely pathogenic divergence factor between lung fibrosis and emphysema.

  2018cites this paper
• Dynamic Reciprocity: The Role of the Extracellular Matrix Microenvironment in Amplifying and Sustaining Pathological Lung Fibrosis

  2018cites this paper
• Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

  2018influential citation
• Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts

  2017cites this paper
• WNT pathway activation in COPD: a two way street between signalling and pathology

  2017cites this paper
• Fibulin-5 promotes airway smooth muscle cell proliferation and migration via modulating Hippo-YAP/TAZ pathway.

  2017cites this paper
• Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy.

  2017cites this paper
• Association Between ADRB2 Genetic Polymorphisms and the Risk of Chronic Obstructive Pulmonary Disease: A Case-Control Study in a Chinese Population

  2017cites this paper
• Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease

  2017cites this paper
• Lung tissue gene-expression signature for the ageing lung in COPD

  2017cites this paper
• A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages

  2017cites this paper
• WNT pathway activation in COPD: a two way street between signalling and pathology

  2017cites this paper
• Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

  2017cites this paper
• Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model

  2017cites this paper
• Compartmentalized signaling in the lung

  2016cites this paper
• MMP-9 genetic polymorphism may confer susceptibility to COPD.

  2016cites this paper
• Efficacy of Continuous Positive Airway Pressure in the Treatment of Chronic Obstructive Pulmonary Disease Combined With Respiratory Failure

  2016cites this paper
• Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.

  2016cites this paper
• University of Groningen Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices

  2016cites this paper
• The WNT receptor Frizzled-8 in pulmonary remodelling and inflammation

  2016cites this paper
• Macrophages: the overlooked target for pulmonary fibrosis and COPD

  2016cites this paper
• Relationships of MMP-9 and TIMP-1 proteins with chronic obstructive pulmonary disease risk: A systematic review and meta-analysis

  2016cites this paper
• The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life

  2016cites this paper
• Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

  2016cites this paper
• A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis

  2016cites this paper
• The extracellular matrix – the under‐recognized element in lung disease?

  2016cites this paper
• Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.

  2016cites this paper
• [Inflammation inhibits vascular fibulin-5 expression: Involvement of transcription factor SOX9].

  2016cites this paper
• MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer

  2016cites this paper
• Fibulin-5 as a potential therapeutic target in COPD

  2016cites this paper
• Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients

  2016cites this paper
• MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation

  2016cites this paper
• Microfibrillar-Associated Protein 4: A Potential Biomarker for Screening for Liver Fibrosis in a Mixed Patient Cohort

  2015cites this paper
• Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

  2015cites this paper
• Characterization of spontaneous airspace enlargement in mice lacking microfibrillar-1 associated protein 4 2

  2015cites this paper