Polyunsaturated fatty acids and their metabolites are crucial to the physiologic and pathophysiologic processes in inflammation. The balance between n-6 and n-3 polyunsaturated fatty acids in body tissues is a key to regulating the inflammatory reaction and preventing exacerbated inflammation in inflammatory disorders. Altering fatty acid type and their composition in phospholipids through diet supplements for beneficial outcomes in disease has been of major interest to the community. The sources of polysaturated fatty acid include de novo synthesis, essential fatty acids obtained from the diet, elongation and desaturation to obtain fatty acids of longer chain length by tissues. The types of fatty acids being esterified in membrane phospholipids provide a characteristic fatty acid composition of the phospholipids which can dictate the characteristics of the inflammatory response depending on the types of metabolites of polyunsaturated fatty acids formed through the lipoxygenase (LOX) and cyclooxygenase (COX) pathways, either promoting or inhibiting the inflammatory process, by controlling intracellular signalling pathways, such as PKC, MAP kinases, PI3 kinase etc While focusing on the use of n-3 polyunsaturated fatty acids in treating rheumatoid arthritis, cardiovascular diseases and asthma, it is highlighted that such treatments are at a ‘cross road’ because of poor understanding of the field of lipidomics and in supplementation approaches in those with various illnesses, including inflammatory diseases.
Polyunsaturated Fatty Acids and Inflammatory Diseases
Published 2011 in Unknown venue
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2011
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Unknown venue
- Publication date
2011-12-16
- Fields of study
Biology, Medicine, Chemistry, Environmental Science
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