Brain ion homeostasis in cerebral ischemia.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Molecular and Chemical Neuropathology

• Publication date

  1988-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/BF03160362PMID 3247069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

  2004cited by this paper
• Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration

  2004cited by this paper
• Stimulus-induced changes in extracellular Na+ and Cl− concentration in relation to changes in the size of the extracellular space

  2004cited by this paper
• Temporal relationship between neurotransmitter release and ion flux during spreading depression and anoxia.

  1987cited by this paper
• Mechanism of hyperpolarizing response of hippocampal cells to anoxia in isolated slices of rat hippocampus

  1987cited by this paper
• Calcium and long‐term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice.

  1986cited by this paper
• Focal Ischemia of the Rat Brain: Autoradiographic Determination of Cerebral Glucose Utilization, Glucose Content, and Blood Flow

  1986cited by this paper
• Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [14C]2-Deoxyglucose Phosphorylation

  1986cited by this paper
• Glutamate and the pathophysiology of hypoxic–ischemic brain damage

  1986cited by this paper
• Cerebral extracellular potassium concentration change and cerebral impedance change in short-term ischemia in gerbil.

  1986cited by this paper
• Membrane current through adenosine‐triphosphate‐regulated potassium channels in guinea‐pig ventricular cells.

  1985cited by this paper
• Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.

  1985cited by this paper
• Ischemia-Induced Shift of Inhibitory and Excitatory Amino Acids from Intra- to Extracellular Compartments

  1985cited by this paper
• Effect of anoxia on ion distribution in the brain.

  1985cited by this paper
• Extracellular pH Changes during Spreading Depression and Cerebral Ischemia: Mechanisms of Brain pH Regulation

  1984cited by this paper
• Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

  1984cited by this paper
• The role of spreading depression in acute brain disorders.

  1984cited by this paper
• Voltage-dependent calcium channels in glial cells.

  1984cited by this paper
• Potassium accumulation around individual purkinje cells in cerebellar slices from the guinea‐pig.

  1983cited by this paper
• The Cortical Ischaemic Penumbra Associated with Occlusion of the Middle Cerebral Artery in the Cat: 1. Topography of Changes in Blood Flow, Potassium Ion Activity, and EEG

  1983cited by this paper
• Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice

  1982cited by this paper
• Energy-requiring cell functions in the ischemic brain. Their critical supply and possible inhibition in protective therapy.

  1982cited by this paper
• Anoxia increases potassium conductance in hippocampal nerve cells.

  1982cited by this paper
• Changes in Extracellular Calcium Activity in Cerebral Ischaemia

  1981cited by this paper
• Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

  1981cited by this paper
• Blood‐Brain Glucose Transfer in Spreading Depression

  1981cited by this paper
• Brain Extracellular Ion Composition and EEG Activity Following 10 Minutes Ischemia in Normoand Hyperglycemic Rats

  1981cited by this paper
• Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex.

  1981cited by this paper
• The Concept of a Blood-Brain Barrier

  1980cited by this paper
• The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate.

  1980cited by this paper
• Extracellular potassium and blood flow in the post-ischemic rat brain

  1980cited by this paper
• Changes in extracellular Ca2+ and K+ activity accompanying hippocampal discharges.

  1980cited by this paper
• Brain extracellular space during spreading depression and ischemia.

  1980cited by this paper
• Cerebral glucose utilization: local changes during and after recovery from spreading cortical depression.

  1979cited by this paper
• Potassium activity in photoreceptors, glial cells and extracellular space in the drone retina: changes during photostimulation.

  1979cited by this paper
• Extracellular ionic variations during spreading depression.

  1978cited by this paper
• The extracellular potassium concentration in brain cortex following ischemia in hypo- and hyperglycemic rats.

  1978cited by this paper
• Changes in extracellular potassium during the spontaneous activity of medullary respiratory neurones

  1978cited by this paper
• Ceiling of stimulus induced rises in extracellular potassium concentration in the cerebral cortex of cat

  1977cited by this paper
• Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischaemia in baboon cerebral cortex.

  1977cited by this paper
• Cation Activities in Reversible Ischemia of the Cat Brain

  1977cited by this paper
• K+-permeability of the blood-brain barrier, investigated by aid of a K+-sensitive microelectrode.

  1977cited by this paper
• Cortical Evoked Potential and Extracellular K+ and H+ at Critical Levels of Brain Ischemia

  1977cited by this paper
• Microelectrode study of spreading depression (SD) in frog retina--general observations of field potential associated with SD.

  1976cited by this paper
• Potassium activity in cerebral cortex in rats during progressive severe hypoglycemia.

  1976cited by this paper
• Microelectrode study of spreading depression (SD) in frog retina-Müller cell activity and [K+] during SD--.

  1976cited by this paper
• The mechanism and applications of Leão's spreading depression of electroencephalographic activity

  1974cited by this paper
• Physiology of the choroid plexus.

  1971cited by this paper
• [Intracellular potentials, EEG and cortical DC potentials in the sensory motor cortex of the cat in acute hypoxia].

  1967cited by this paper
• Spreading cortical depression of Leao.

  1959cited by this paper
• SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

  1944cited by this paper
• ACUTE ARREST OF CEREBRAL CIRCULATION IN MAN: LIEUTENANT RALPH ROSSEN (MC), U.S.N.R.

  1943cited by this paper

• The astrocytic engine: Na+,K+-ATPase at the nexus of brain function and malfunction.

  2025cites this paper
• Unraveling brain diseases: the promise of brain-on-a-chip models.

  2024cites this paper
• Multimodal imaging of hemorrhagic transformation biomarkers in an ischemic stroke model.

  2022cites this paper
• KCC2 drives chloride microdomain formation in dendritic blebbing.

  2022cites this paper
• New Perspectives for Developing Therapeutic Bioconjugates of Metabolite-Depleting Enzymes: Lessons Learned Combating Glutamate Excitotoxicity.

  2022cites this paper
• Cerebrospinal fluid influx drives acute ischemic tissue swelling

  2020cites this paper
• Quantitative fluorescence lifetime imaging uncovers a novel role for KCC2 chloride transport in dendritic microdomains

  2020cites this paper
• Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells

  2020cites this paper
• Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy.

  2019cites this paper
• Revealing the Penumbra through Imaging Elemental Markers of Cellular Metabolism in an Ischemic Stroke Model.

  2018cites this paper
• Signaling Pathway of β-Adrenergic Receptor in Astrocytes and its Relevance to Brain Edema

  2017cites this paper
• The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization

  2017cites this paper
• Glial Cells and Integrity of the Nervous System.

  2016cites this paper
• Astrocyte Cultures Mimicking Brain Astrocytes in Gene Expression, Signaling, Metabolism and K+ Uptake and Showing Astrocytic Gene Expression Overlooked by Immunohistochemistry and In Situ Hybridization

  2016cites this paper
• Glia and glial polyamines. Role in brain function in health and disease

  2016cites this paper
• Science Journals — AAAS

  2016cites this paper
• Science Journals — AAAS

  2016cites this paper
• The Astrocytic Na+, K+-ATPase: Stimulation by Increased Extracellular K+, β-Adrenergic Activation, Ouabain-Mediated Signaling, and Interaction with the Transporter NKCC1

  2016cites this paper
• Optogenetic investigation of neuronal excitability and sensory-motor function following a transient global ischemia in mice

  2015cites this paper
• GABA Receptor and KCa Channel-mediated Electrical Suppression in Anoxic Cortical Pyramidal Neurons of the Painted Turtle (Chrysemys picta bellii)

  2015influential citation
• Mechanisms underlying presynaptic Ca2+ transient and vesicular glutamate release at a CNS nerve terminal during in vitro ischaemia

  2015cites this paper
• Role of the Astrocytic Na+, K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization

  2015cites this paper
• Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death.

  2015cites this paper
• Uav operators workload assessment by optical brain imaging technology (fnir)

  2015cites this paper
• Metabotropic glutamate receptors in oligodendrocytes and astrocytes in white and grey matter brain regions

  2014cites this paper
• In vitro ischemia-induced changes in the transcriptome of hippocampal neurons: neuroprotective pathways in brain ischemia

  2014cites this paper
• Changes in Hypothalamus–Pituitary–Adrenal Axis Following Transient Ischemic Attack

  2014cites this paper
• Link Between Oxidative Stress and Acute Brain Ischemia

  2014cites this paper
• The role of glia in stress: polyamines and brain disorders.

  2014cites this paper
• Synaptic and extrasynaptic glutamate signaling in ischemic stroke.

  2014cites this paper
• Antagonists of the Vasopressin V1 Receptor and of the β1-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes – but the Mechanisms Differ

  2014influential citation
• Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K+ and Decreased Ca2+ Concentrations in Extracellular Fluid

  2014cites this paper
• Adrenal Axis Following Transient Ischemic Attack − Pituitary − Changes in Hypothalamus

  2013cites this paper
• Mechanisms for L-channel-mediated increase in [Ca(2+)]i and its reduction by anti-bipolar drugs in cultured astrocytes combined with its mRNA expression in freshly isolated cells support the importance of astrocytic L-channels.

  2013cites this paper
• Caratterizzazione pre-clinica di una nuova strategia terapeutica per l'ischemia cerebrale identificata mediante drug repurposing di un antibiotico macrolide

  2013cites this paper
• Acts as a Mediator of Communication from Neurons to 2

  2013cites this paper
• Characterization of neural ion regulation dysfunction during insult and evaluation of micro-opioid receptor activation during simulated ischemia in the pre-botzinger complex

  2013cites this paper
• Hyperglycemia in stroke and possible treatments

  2013cites this paper
• Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke

  2012cites this paper
• A Mathematical Model of the Metabolic and Perfusion Effects on Cortical Spreading Depression

  2012cites this paper
• Responses to Cortical Spreading Depression under Oxygen Deficiency

  2012cites this paper
• 2 Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke

  2012cites this paper
• Extracellular Ca2+ Acts as a Mediator of Communication from Neurons to Glia

  2012cites this paper
• Understanding the cerebroprotective actions of the ACE2/Ang-(1-7)/Mas axis during ischemic and hemorrhagic stroke

  2012cites this paper
• Painted Turtle Cortex is Resistant to an in Vitro Mimic of the Ischemic Mammalian Penumbra

  2012cites this paper
• The pharmacological control of neuronal excitability in the retinal spreading depression model of migraine.

  2012cites this paper
• Ischemic Stroke: Basic Pathophysiology and Neuroprotective Strategies

  2011cites this paper
• Astrocyte ERK phosphorylation precedes K+‐induced swelling but follows hypotonicity‐induced swelling

  2011cites this paper
• Spreading Depression: A Self-organized Excitation Depression Wave in Different Gravity Conditions

  2011cites this paper
• Cerebral Blood Flow and Metabolism and Cerebral Ischemia

  2011cites this paper
• Implications of Gliotransmission for the Pharmacotherapy of CNS Disorders

  2011cites this paper
• Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels

  2010cites this paper
• Excitotoxic ATP and Glutamate Signalling during Central Nervous System Ischaemia

  2010influential citation
• Simulated ischaemia induces Ca2+‐independent glutamatergic vesicle release through actin filament depolymerization in area CA1 of the hippocampus

  2010cites this paper
• Mitochondrial potassium sequestration and neuroprotection is mediated by connexin43

  2010cites this paper
• Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems

  2009cites this paper
• Excitotoxic mechanisms in the hippocamus and cerebellum during brain ischemia.

  2009cites this paper
• Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta.

  2009cites this paper
• Mitochondrial activity and brain functions during cortical depolarization

  2008cites this paper
• Extrazelluläre Ionenänderungen während Cortical Spreading Ischaemia im zerebralen Kortex der Ratte

  2008cites this paper
• Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia

  2008cites this paper
• Ischemic neuronal damage.

  2008cites this paper
• Spreading depolarizations occur in human ischemic stroke with high incidence

  2008cites this paper
• Bioenergetics of cerebral ischemia: a cellular perspective.

  2008cites this paper
• Cortical spreading depression causes and coincides with tissue hypoxia

  2007cites this paper
• An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis.

  2007cites this paper
• Astrocyte metabolism and signaling during brain ischemia

  2007cites this paper
• Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale

  2006cites this paper
• A 3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA 1 hippocampus in vitro

  2006cites this paper
• Diadenosine polyphosphate analogue controls postsynaptic excitation in CA 3-CA 1 synapses via a nitric oxide ( NO )-dependent mechanism

  2006cites this paper
• A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro

  2006cites this paper
• Diadenosine Polyphosphate Analog Controls Postsynaptic Excitation in CA3-CA1 Synapses via a Nitric Oxide-Dependent Mechanism

  2006cites this paper
• Effects of anesthesia on the responses to cortical spreading depression in the rat brain in vivo

  2006cites this paper
• ERYTHROPOIETIN AND THE NERVOUS SYSTEM Novel Therapeutic Options for Neuroprotection

  2006cites this paper
• Role of Na+‐H+ and Na+‐Ca2+ exchange in hypoxia‐related acute astrocyte death

  2005cites this paper
• Chelation of intracellular calcium reduces cell death after hyperglycemic in vitro ischemia in murine hippocampal slice cultures.

  2005cites this paper
• Failure and function of intracellular pH regulation in acute hypoxic‐ischemic injury of astrocytes

  2005cites this paper
• Astrocytic contributions to bioenergetics of cerebral ischemia

  2005cites this paper
• Selective sparing of hippocampal CA3 cells following in vitro ischemia is due to selective inhibition by acidosis

  2005influential citation
• Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion.

  2004cites this paper
• Hypothermic Protection in Traumatic Brain Injury

  2004cites this paper
• The influence of repeated spreading depression-induced calcium transients on neuronal viability in moderately hypoglycemic rats

  2004cites this paper
• New roles for astrocytes: redefining the functional architecture of the brain.

  2003cites this paper
• Mouse Hippocampal Organotypic Tissue Cultures Exposed to In Vitro “Ischemia” Show Selective and Delayed CA1 Damage that is Aggravated by Glucose

  2003influential citation
• Uptake of glutamate is impaired in the cortical penumbra of the rat following middle cerebral artery occlusion: An in vivo microdialysis extraction study

  2003cites this paper
• Eubaric hyperoxemia and experimental cerebral infarction

  2002cites this paper
• Intercellular calcium signaling mediated by point-source burst release of ATP

  2002cites this paper
• Beyond the role of glutamate as a neurotransmitter

  2002cites this paper
• Cation dysfunction associated with cerebral ischemia followed by reperfusion: a comparison of microdialysis and ion-selective electrode methods.

  2002cites this paper
• Spreading depression: a review of the clinical relevance.

  2001cites this paper
• The effect of ethanol on metabolic, hemodynamic and electrical responses to cortical spreading depression.

  2001cites this paper
• Glutamate Injury–Induced Epileptogenesis in Hippocampal Neurons: An In Vitro Model of Stroke-Induced “Epilepsy”

  2001cites this paper
• Intracellular Ca(2+) changes induced by in vitro ischemia in rat retinal slices.

  2001cites this paper
• The Nootropic Drug Vinpocetine Inhibits Veratridine-Induced [Ca2+]i Increase in Rat Hippocampal CA1 Pyramidal Cells

  2001cites this paper
• Spreading Depression-Induced Cyclooxygenase-2 Expression in the Cortex

  2000cites this paper
• High Speed Diffusion Magnetic Resonance Imaging of Ischemia and Spontaneous Periinfarct Spreading Depression after Thromboembolic Stroke in the Rat

  2000cites this paper
• Brain metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: 1. Methodological aspects

  2000cites this paper
• Characterization of cortical spreading depression in rat using radio frequency current density imaging

  2000cites this paper
• Oxidative Metabolism, Apoptosis and Perinatal Brain Injury

  1999cites this paper
• Mild hypothermia improves recovery of cortical extracellular potassium ion activity and excitability after middle cerebral artery occlusion in the rat.

  1999cites this paper