Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Glycobiology

• Publication date

  2013-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1093/glycob/cwt079PMID 24026238
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell-penetrating peptides: from cell cultures to in vivo applications.

  2013cited by this paper
• Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant?

  2012cited by this paper
• Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

  2012influential reference
• Membrane pores in the pathogenesis of neurodegenerative disease.

  2012cited by this paper
• Soluble Aβ oligomer production and toxicity

  2012cited by this paper
• Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein

  2012cited by this paper
• The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

  2012influential reference
• Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage.

  2012cited by this paper
• Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.

  2011cited by this paper
• Alzheimer's disease.

  2011influential reference
• Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

  2011cited by this paper
• Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons--involvement of heat shock protein 27.

  2011cited by this paper
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  2011cited by this paper
• Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease*

  2011cited by this paper
• Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory

  2011cited by this paper
• Amyloid precursor protein processing and Alzheimer's disease.

  2011cited by this paper
• Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C

  2011cited by this paper
• Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

  2010cited by this paper
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  2010cited by this paper
• Heparan sulfate mediates amyloid-beta internalization and cytotoxicity.

  2010cited by this paper
• Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers*

  2010cited by this paper
• Alzheimer's disease.

  2010cited by this paper
• Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

  2009cited by this paper
• Potentiation of naphthoxyloside cytotoxicity on human tumor cells by difluoromethylornithine and spermine-NONOate.

  2009cited by this paper
• Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake*

  2009cited by this paper
• S-Nitrosylation of secreted recombinant human glypican-1

  2009cited by this paper
• Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation.

  2009cited by this paper
• Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

  2009cited by this paper
• Structural Classification of Toxic Amyloid Oligomers*

  2008cited by this paper
• Amyloid Precursor Protein Trafficking, Processing, and Function*

  2008influential reference
• Heparan Sulfate Degradation Products Can Associate with Oxidized Proteins and Proteasomes*

  2007cited by this paper
• Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice

  2007cited by this paper
• The APP family of proteins: similarities and differences.

  2007influential reference
• Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.

  2006cited by this paper
• Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.

  2006cited by this paper
• The Amyloid Precursor Protein (APP) of Alzheimer Disease and Its Paralog, APLP2, Modulate the Cu/Zn-Nitric Oxide-catalyzed Degradation of Glypican-1 Heparan Sulfate in Vivo*

  2005cited by this paper
• The amyloid‐β precursor protein: integrating structure with biological function

  2005influential reference
• Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination.

  2005cited by this paper
• The amyloid-beta precursor protein: integrating structure with biological function.

  2005cited by this paper
• Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

  2004cited by this paper
• Novel aspects of glypican glycobiology

  2004cited by this paper
• Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.

  2004cited by this paper
• The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.

  2004cited by this paper
• Glypican‐1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease

  2004cited by this paper
• Tumor attenuation by 2(6-hydroxynaphthyl)-beta-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.

  2004cited by this paper
• Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

  2004cited by this paper
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  2004cited by this paper
• Prion, Amyloid β-derived Cu(II) Ions, or Free Zn(II) Ions Support S-Nitroso-dependent Autocleavage of Glypican-1 Heparan Sulfate*

  2003cited by this paper
• Nitric Oxide-dependent Processing of Heparan Sulfate in Recycling S-Nitrosylated Glypican-1 Takes Place in Caveolin-1-containing Endosomes*

  2002cited by this paper
• Copper-dependent Autocleavage of Glypican-1 Heparan Sulfate by Nitric Oxide Derived from Intrinsic Nitrosothiols*

  2002cited by this paper
• Modulations of Glypican-1 Heparan Sulfate Structure by Inhibition of Endogenous Polyamine Synthesis

  2001cited by this paper
• Differences in the uptake and nuclear localization of anti‐proliferative heparan sulfate between human lung fibroblasts and human lung carcinoma cells

  2001cited by this paper
• Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth.

  1999cited by this paper
• The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer’s Disease*

  1998cited by this paper
• Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth*

  1996influential reference
• [Amyloid precursor protein and Alzheimer's disease].

  1993influential reference
• Transport of heparan sulfate into the nuclei of hepatocytes.

  1986cited by this paper
• A unique heparan sulfate in the nuclei of hepatocytes: structural changes with the growth state of the cells

  1986cited by this paper

• Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis

  2024influential citation
• Heparan Sulfate in Alzheimer's Disease: Aberrant expression and functions in molecular pathways related to amyloid-β metabolism.

  2023cites this paper
• Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells

  2023cites this paper
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  2022cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2016cites this paper
• Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.

  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper