Molecular and genetic insights into T cell antigen receptor structure and function.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Annual Review of Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV.GE.25.120191.002415PMID 1839878
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3

  1991cited by this paper
• Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line.

  1991cited by this paper
• Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

  1991cited by this paper
• Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

  1991cited by this paper
• Fc receptors.

  1991cited by this paper
• Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

  1991cited by this paper
• The CD3‐gamma and CD3‐delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

  1991cited by this paper
• The cell biology of antigen processing and presentation.

  1991cited by this paper
• A novel strategy for the generation of T cell lines lacking expression of endogenous alpha- and/or beta-chain T cell receptor genes.

  1991cited by this paper
• Six chains of the human T cell antigen receptor.CD3 complex are necessary and sufficient for processing the receptor heterodimer to the cell surface.

  1991cited by this paper
• Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor

  1991cited by this paper
• The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.

  1991cited by this paper
• Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides.

  1991cited by this paper
• An analysis of the role of guanine nucleotide binding proteins in antigen receptor/CD3 antigen coupling to phospholipase C.

  1991cited by this paper
• Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms.

  1991cited by this paper
• Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.

  1991cited by this paper
• Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.

  1990cited by this paper
• Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.

  1990cited by this paper
• Stimulation of the phosphatidylinositol pathway can induce T-cell activation.

  1990cited by this paper
• Genetic and mutational analysis of the T-cell antigen receptor.

  1990cited by this paper
• Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

  1990cited by this paper
• A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum.

  1990cited by this paper
• Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

  1990cited by this paper
• Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains.

  1990cited by this paper
• CD3 zeta subunit can substitute for the gamma subunit of Fc epsilon receptor type I in assembly and functional expression of the high-affinity IgE receptor: evidence for interreceptor complementation.

  1990cited by this paper
• A fraction of CD3 epsilon subunits exists as disulfide-linked dimers in both human and murine T lymphocytes.

  1990cited by this paper
• Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

  1990cited by this paper
• Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors.

  1990cited by this paper
• T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.

  1990cited by this paper
• Developmental biology of T cells in T cell-receptor transgenic mice.

  1990cited by this paper
• Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells.

  1990cited by this paper
• Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation

  1990cited by this paper
• Human T cell receptor-gamma and -delta chain pairing analyzed by transfection of a T cell receptor-delta negative mutant cell line.

  1990cited by this paper
• Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.

  1990cited by this paper
• Mutants in signal transduction through the T-cell antigen receptor.

  1990cited by this paper
• T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.

  1990cited by this paper
• Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation

  1990cited by this paper
• Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.

  1990cited by this paper
• Structure and function of the T cell antigen receptor.

  1990cited by this paper
• Stimulation of p21ras upon T-cell activation

  1990cited by this paper
• Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

  1990cited by this paper
• The implications of subunit interactions for the structure of the T cell receptor‐CD3 complex

  1990cited by this paper
• Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

  1990cited by this paper
• Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation.

  1990cited by this paper
• Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

  1990cited by this paper
• Developmental biology of T cells in T cell-receptor transgenic mice.

  1990cited by this paper
• Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants.

  1989cited by this paper
• T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates.

  1989cited by this paper
• Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly

  1989cited by this paper
• Inability of CD8α′polypeptides to associate with p56 lck correlates with impaired function in vitro and lack of expression in vivo

  1989cited by this paper
• Co-association of CD3ζ with a receptor (CD16) for IgG Fc on human natural killer cells

  1989cited by this paper
• CD3-negative natural killer cells express ε TCR as part of a novel molecular complex

  1989cited by this paper
• Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

  1989cited by this paper
• Surface expression of the T cell receptor complex requires charged residues within the α chain transmembrane region

  1989cited by this paper
• Contingent genetic regulatory events in T lymphocyte activation.

  1989cited by this paper
• Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid.

  1989cited by this paper
• Antigen recognition by class I-restricted T lymphocytes.

  1989cited by this paper
• Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

  1989cited by this paper
• CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells.

  1989cited by this paper
• The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors

  1989cited by this paper
• Biochemical characterization of the eta chain of the T-cell receptor. A unique subunit related to zeta.

  1989cited by this paper
• The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

  1989cited by this paper
• Assembly, intracellular processing, and expression at the cell surface of the human alpha beta T cell receptor/CD3 complex. Function of the CD3-zeta chain.

  1989cited by this paper
• Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

  1989cited by this paper
• A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester

  1989cited by this paper
• Inositol phosphates and cell signalling

  1989cited by this paper
• Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

  1989cited by this paper
• Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

  1989cited by this paper
• Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro.

  1989cited by this paper
• Activation-driven programmed cell death and T cell receptor zeta eta expression.

  1989cited by this paper
• An immunodeficiency characterized by defective signal transduction in T lymphocytes.

  1989cited by this paper
• Studies of inositol phospholipid-specific phospholipase C.

  1989cited by this paper
• The leukocyte common antigen family.

  1989cited by this paper
• Immunology. Antigens for gamma/delta T cells.

  1989cited by this paper
• Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post‐endoplasmic reticulum compartment

  1989cited by this paper
• Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

  1989cited by this paper
• Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

  1989cited by this paper
• Early signal transduction by the antigen receptor without commitment to T cell activation.

  1988cited by this paper
• Differential activation requirements for virgin and memory T cells.

  1988cited by this paper
• Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex.

  1988cited by this paper
• Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

  1988cited by this paper
• Cell-cell adhesion mediated by CD8 and MHC class I molecules

  1988cited by this paper
• At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.

  1988cited by this paper
• A T cell receptor-associated GTP-binding protein triggers T cell receptor-mediated granule exocytosis in cytotoxic T lymphocytes.

  1988cited by this paper
• Transfection of genes encoding the T cell receptor-associated CD3 complex into COS cells results in assembly of the macromolecular structure.

  1988cited by this paper
• T-cell antigen receptor genes and T-cell recognition

  1988cited by this paper
• Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells.

  1988cited by this paper
• The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

  1988cited by this paper
• The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.

  1988cited by this paper
• Characterization and expression of the murine CD3-epsilon gene.

  1988cited by this paper
• The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

  1988cited by this paper
• The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

  1988cited by this paper
• Molecular cloning of the zeta chain of the T cell antigen receptor.

  1988cited by this paper
• The biosynthesis and assembly of T cell receptor alpha- and beta-chains with the CD3 complex.

  1988cited by this paper
• Familial defect in the surface expression of the T-cell receptor-CD3 complex.

  1988cited by this paper
• The gamma delta T cell receptor.

  1988cited by this paper
• The T cell receptor/CD3 complex: a dynamic protein ensemble.

  1988cited by this paper
• Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex.

  1988cited by this paper
• Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

  1988cited by this paper
• Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains

  1988cited by this paper

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