Defective Mitochondrial Gene Expression Results in Reactive Oxygen Species-Mediated Inhibition of Respiration and Reduction of Yeast Life Span

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.02360-05PMID 16782871PMCID PMC1489155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cross-compartment protection by SOD1.

  2005cited by this paper
• Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

  2005cited by this paper
• Yeast longevity and aging--the mitochondrial connection.

  2005cited by this paper
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

  2005cited by this paper
• Mitochondria, oxidants, and aging.

  2005cited by this paper
• Faculty Opinions recommendation of Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase.

  2004cited by this paper
• Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

  2004cited by this paper
• Premature ageing in mice expressing defective mitochondrial DNA polymerase

  2004cited by this paper
• Superoxide Inhibits 4Fe-4S Cluster Enzymes Involved in Amino Acid Biosynthesis

  2004cited by this paper
• Coupling the mitochondrial transcription machinery to human disease.

  2004cited by this paper
• Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Life Span in Saccharomyces cerevisiae*

  2004cited by this paper
• Mitochondrial Protein Oxidation in Yeast Mutants Lacking Manganese-(MnSOD) or Copper- and Zinc-containing Superoxide Dismutase (CuZnSOD)

  2004cited by this paper
• Mitochondrial respiratory-chain diseases.

  2003cited by this paper
• The chronological life span of Saccharomyces cerevisiae.

  2003cited by this paper
• Multiple Interactions Involving the Amino-terminal Domain of Yeast mtRNA Polymerase Determine the Efficiency of Mitochondrial Protein Synthesis*

  2003cited by this paper
• Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

  2002cited by this paper
• Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

  2002cited by this paper
• Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression.

  2002cited by this paper
• Nab2p Is Required for Poly(A) RNA Export in Saccharomyces cerevisiae and Is Regulated by Arginine Methylation via Hmt1p*

  2002cited by this paper
• Nam1p, a Protein Involved in RNA Processing and Translation, Is Coupled to Transcription through an Interaction with Yeast Mitochondrial RNA Polymerase*

  2001cited by this paper
• A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

  2001cited by this paper
• Oxidative stress during aging of stationary cultures of the yeast Saccharomyces cerevisiae.

  2000cited by this paper
• Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase.

  1999cited by this paper
• Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.

  1999cited by this paper
• Yeast as a model for human mtDNA replication.

  1999cited by this paper
• Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity.

  1998influential reference
• Mitochondrial DNA maintenance in vertebrates.

  1997cited by this paper
• Superoxide Production by the Mitochondrial Respiratory Chain

  1997cited by this paper
• Oxidative Stress, Caloric Restriction, and Aging

  1996cited by this paper
• Kinetics of spindle pole body separation in budding yeast.

  1995cited by this paper
• Oxidative damage and mitochondrial decay in aging.

  1994cited by this paper
• Getting started with yeast.

  1991cited by this paper
• Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

  1990cited by this paper
• A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

  1989cited by this paper
• Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome.

  1986cited by this paper
• Genetics of mitochondrial biogenesis.

  1986cited by this paper
• Mitochondrial role in cell aging.

  1980cited by this paper
• The cellular production of hydrogen peroxide.

  1972cited by this paper
• Aging: a theory based on free radical and radiation chemistry.

  1956cited by this paper

• Chromatin stability safeguards mitochondrial homeostasis and prevents mTORC1 hyperactivation

  2025cites this paper
• Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels

  2025cites this paper
• Chromosome duplication causes premature aging via defects in ribosome quality control

  2025cites this paper
• Proteomic and phosphoproteomic signatures of aging mouse liver

  2025cites this paper
• Glucosinolates from Seed-Press Cake of Camelina sativa (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration

  2025cites this paper
• Intermittent caloric restriction effectively increases yeast chronological lifespan

  2024cites this paper
• Glucosylglycerol and proline reverse the effects of glucose on Rhodosporidium toruloides lifespan

  2024cites this paper
• P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance

  2024influential citation
• Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control

  2024cites this paper
• Mitochondrial Reactive Oxygen Species in Infection and Immunity

  2024cites this paper
• Overexpression of polyphosphate polymerases and deletion of polyphosphate phosphatases shorten the replicative lifespan in yeast

  2023cites this paper
• Exogenous glucosylglycerol and proline extend the chronological lifespan of Rhodosporidium toruloides

  2023cites this paper
• Glucosylglycerol Extends Chronological Lifespan of the Budding Yeast via an Increased Osmolarity Response

  2023cites this paper
• Absence of the Rpb9 subunit of RNA polymerase II reduces the chronological life span in fission yeast

  2022cites this paper
• Engineering microbial cell viability for enhancing chemical production by second codon engineering.

  2022cites this paper
• Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

  2022cites this paper
• Ehretiquinone from Onosma bracteatum Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction

  2021cites this paper
• Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss

  2021cites this paper
• Mitophagy Impairment Aggravates Cisplatin-Induced Ototoxicity

  2021cites this paper
• Hair Cell Protection from Ototoxic Drugs

  2021cites this paper
• Increased mitochondrial content and function by resveratrol and select flavonoids protects against benzo[a]pyrene-induced bioenergetic dysfunction and ROS generation in a cell model of neoplastic transformation.

  2020cites this paper
• Domestication reprogrammed the budding yeast life cycle

  2020cites this paper
• Reductive Stress: New Insights in Physiology and Drug Tolerance of Mycobacterium

  2020cites this paper
• Nicotinamide, Nicotinamide Riboside and Nicotinic Acid—Emerging Roles in Replicative and Chronological Aging in Yeast

  2020cites this paper
• Schizosaccharomyces pombe Mti2 and Mti3 act in conjunction during mitochondrial translation initiation

  2019cites this paper
• The cell biology of quiescent yeast – a diversity of individual scenarios

  2019cites this paper
• The vacuolar shapes of ageing: From function to morphology.

  2019cites this paper
• Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review

  2019cites this paper
• Cell organelles and yeast longevity: an intertwined regulation

  2019cites this paper
• Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism

  2018cites this paper
• Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1

  2018cites this paper
• Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeast Saccharomyces cerevisiae

  2018cites this paper
• Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells

  2018cites this paper
• Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate

  2018cites this paper
• Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDylation status

  2018cites this paper
• Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis.

  2018cites this paper
• Allopurinol supplementation of the growth medium enhances the fermentation of lignocellulosic hydrolysates to ethanol by Saccharomyces cerevisiae

  2018cites this paper
• Antioxidant Vitamins and Ageing.

  2018cites this paper
• Oxidative Stress and Amyloid Toxicity: Insights From Yeast

  2017cites this paper
• Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

  2017cites this paper
• Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae

  2017cites this paper
• Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity

  2017cites this paper
• The Evolution of Dark Matter in the Mitogenome of Seed Beetles

  2017cites this paper
• Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2

  2017cites this paper
• Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging.

  2017cites this paper
• A stimulates aberrant mitochondrial biogenesis through a CDK 4 / Rb-independent pathway

  2017cites this paper
• Mutually Synergistic Nanoparticles for Effective Thermo‐Molecularly Targeted Therapy

  2017cites this paper
• Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2

  2017cites this paper
• Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

  2016cites this paper
• Understanding genetic changes underlying the molybdate resistance and the glutathione production in Saccharomyces cerevisiae wine strains using an evolution-based strategy

  2016cites this paper
• An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast

  2016cites this paper
• The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation

  2016cites this paper
• Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae

  2016cites this paper
• Lack of phosphatidate phosphatase causes reduced chronological life span through increased energy expenditure and oxidative stress

  2015cites this paper
• The Stationary-Phase Cells of Saccharomyces cerevisiae Display Dynamic Actin Filaments Required for Processes Extending Chronological Life Span

  2015cites this paper
• Dietary restriction, mitochondrial function and aging: from yeast to humans.

  2015cites this paper
• Mechanisms Underlying the Essential Role of Mitochondria in Chronological Aging of the Yeast Saccharomyces cerevisiae

  2015cites this paper
• Endogenic oxidative stress response contributes to glutathione over-accumulation in mutant Saccharomyces cerevisiae Y518

  2015cites this paper
• Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span*

  2015cites this paper
• The many ways to age for a single yeast cell

  2014cites this paper
• A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo*

  2014cites this paper
• CHARACTERIZING THE ROLE OF MITOCHONDRIA IN THE TOXICITY OF TRICHOTHECENES PRODUCED BY FUSARIUM GRAMINEARUM

  2014cites this paper
• Mitochondria as integral modulators of cellular signaling

  2014cites this paper
• Elimination of damaged mitochondria through mitophagy reduces mitochondrial oxidative stress and increases tolerance to trichothecenes

  2014influential citation
• Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan.

  2014cites this paper
• Mitochondrial Aminopeptidase Deletion Increases Chronological Lifespan and Oxidative Stress Resistance while Decreasing Respiratory Metabolism in S. cerevisiae

  2013influential citation
• Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

  2013cites this paper
• Epigenetic silencing mediates mitochondria stress-induced longevity.

  2013cites this paper
• Ethanol and Acetate Acting as Carbon/Energy Sources Negatively Affect Yeast Chronological Aging

  2013cites this paper
• LOW METABOLIC RATES IN SALAMANDERS ARE CORRELATED WITH WEAK SELECTIVE CONSTRAINTS ON MITOCHONDRIAL GENES

  2013cites this paper
• Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair

  2013cites this paper
• EVOLUCIÓN GENÓMICA POR DISEÑO MOLECULAR DE LEVADURAS INDUSTRIALES

  2013cites this paper
• SOD2 deficiency promotes aging phenotypes in mouse skin

  2012cites this paper
• Replicative and chronological aging in Saccharomyces cerevisiae.

  2012cites this paper
• Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.

  2012influential citation
• Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast

  2012cites this paper
• Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60

  2012cites this paper
• PNPASE and RNA trafficking into mitochondria.

  2012cites this paper
• LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model.

  2012cites this paper
• Maximising the yeast chronological lifespan.

  2012cites this paper
• Aging Research in Yeast

  2012cites this paper
• The generation of oxidative stress-induced rearrangements in Saccharomyces cerevisiae mtDNA is dependent on the Nuc1 (EndoG/ExoG) nuclease and is enhanced by inactivation of the MRX complex.

  2012cites this paper
• Genome-wide analysis of transcription initiation and promoter architecture in eukaryotes

  2012cites this paper
• The Role of Mitochondrial Dysfunction in Neurodegenerative Proteinopathies and Aging.

  2012influential citation
• Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction.

  2012cites this paper
• Res Computans: The Living Subject from Yeast to Human

  2011cites this paper
• Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry.

  2011cites this paper
• Identification of Mutations that Extend the Fission Yeast Schizosaccharomyces pombe Chronological Lifespan by a Novel Parallel Selection Approach

  2011cites this paper
• Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.

  2011cites this paper
• The effect of trehalose on the fermentation performance of aged cells of Saccharomyces cerevisiae

  2011cites this paper
• Conserved role of medium acidification in chronological senescence of yeast and mammalian cells

  2011cites this paper
• Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae.

  2011cites this paper
• Unravelling the genomic structure of Saccharomyces cerevisiae

  2011cites this paper
• Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

  2011cites this paper
• Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.

  2011influential citation
• The role of redox-sensitive antioxidants in oxidative stress signalling in Candida albicans

  2011cites this paper
• Extending life span by increasing oxidative stress.

  2011cites this paper
• Progress on Molecular Mechanisms of Chronological Ageing in Model Organism Saccharomyces cerevisiae : Progress on Molecular Mechanisms of Chronological Ageing in Model Organism Saccharomyces cerevisiae

  2011cites this paper
• How budding yeast sense and transduce the oxidative stress signal and the impact in cell growth and morphogenesis.

  2010cites this paper
• Cu,Zn‐superoxide dismutase is required for cell wall structure and for tolerance to cell wall‐perturbing agents in Saccharomyces cerevisiae

  2010cites this paper