Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of applied physiology

• Publication date

  2011-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/japplphysiol.00071.2011PMID 21454745PMCID PMC3119136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.

  2011influential reference
• Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO

  2010cited by this paper
• Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise.

  2010cited by this paper
• Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise.

  2010influential reference
• Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

  2010influential reference
• Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training.

  2010cited by this paper
• Food sources of nitrates and nitrites: the physiologic context for potential health benefits.

  2009cited by this paper
• Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

  2009influential reference
• Plasma nitrite response and arterial reactivity differentiate vascular health and performance.

  2009cited by this paper
• Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.

  2009cited by this paper
• Nitrite as regulator of hypoxic signaling in mammalian physiology

  2009cited by this paper
• Nitrite directly vasodilates hypoxic vasculature via nitric oxide‐dependent and ‐independent pathways

  2009cited by this paper
• The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

  2008cited by this paper
• The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash.

  2008cited by this paper
• Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

  2008influential reference
• Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

  2007cited by this paper
• Dynamics of noninvasively estimated microvascular O2 extraction during ramp exercise.

  2007cited by this paper
• Effects of dietary nitrate on oxygen cost during exercise

  2007influential reference
• Prior exercise speeds pulmonary O2 uptake kinetics by increases in both local muscle O2 availability and O2 utilization.

  2007cited by this paper
• ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography

  2006cited by this paper
• Exercise training decreases ventilatory requirements and exercise-induced hyperinflation at submaximal intensities in patients with COPD.

  2006cited by this paper
• Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics

  2006cited by this paper
• Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.

  2005cited by this paper
• Regional and whole-body markers of nitric oxide production following hyperemic stimuli.

  2005cited by this paper
• Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion.

  2004cited by this paper
• Influence of L-NAME on pulmonary O2 uptake kinetics during heavy-intensity cycle exercise.

  2004cited by this paper
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  2004cited by this paper
• Inorganic nitrate is a possible source for systemic generation of nitric oxide.

  2004influential reference
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  2004cited by this paper
• Nitrate, bacteria and human health

  2004cited by this paper
• Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator

  2004cited by this paper
• The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.

  2003cited by this paper
• Critical issues in peripheral arterial disease detection and management: a call to action.

  2003cited by this paper
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  2003cited by this paper
• Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.

  2003cited by this paper
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  2003cited by this paper
• Endothelial function testing as a biomarker of vascular disease.

  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1991cited by this paper

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