A novel approach to enhancing cellular glutathione levels

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Neurochemistry

• Publication date

  2008-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1471-4159.2008.05620.xPMID 18702664PMCID PMC2644427
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of thiol-containing molecule cysteamine on the induction of inducible nitric oxide synthase in hepatocytes.

  2007cited by this paper
• Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes: central role of free cysteine and cysteamine.

  2007cited by this paper
• System xc− Activity and Astrocytes Are Necessary for Interleukin-1β-Mediated Hypoxic Neuronal Injury

  2007cited by this paper
• Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice

  2007cited by this paper
• Redox Control of Neural Function: Background, Mechanisms, and Significance

  2006cited by this paper
• Distribution of the Cystine/Glutamate Antiporter System x− c in the Brain, Kidney, and Duodenum

  2006cited by this paper
• Cystine/Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation

  2006cited by this paper
• Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc– protects from oxidative glutamate toxicity

  2006cited by this paper
• Electron‐transfer capacity of catechin derivatives and influence on the cell cycle and apoptosis in HT29 cells

  2006cited by this paper
• The effects of stress and aging on glutathione metabolism.

  2005cited by this paper
• Conjugation of catechins with cysteine generates antioxidant compounds with enhanced neuroprotective activity.

  2005cited by this paper
• Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice*

  2005cited by this paper
• Immunomodulatory activity of a new family of antioxidants obtained from grape polyphenols.

  2004cited by this paper
• Glutathione metabolism and its implications for health.

  2004cited by this paper
• Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture.

  2004cited by this paper
• The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

  2003cited by this paper
• Amino acid transporters: roles in amino acid sensing and signalling in animal cells.

  2003influential reference
• Cysteinyl-flavan-3-ol conjugates from grape procyanidins. Antioxidant and antiproliferative properties.

  2002cited by this paper
• Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.

  2002cited by this paper
• Glutathione in defense and signaling: lessons from a small thiol.

  2002cited by this paper
• Glutathione in Defense and Signaling

  2002cited by this paper
• Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.

  2001cited by this paper
• Mechanism of Growth Stimulation of L 1210 Cells by 2-Mercaptoethanol in Vitro

  2001influential reference
• How Protein Kinase C Activation Protects Nerve Cells from Oxidative Stress-Induced Cell Death

  2001cited by this paper
• Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms.

  2001cited by this paper
• Oxytosis: A novel form of programmed cell death.

  2001cited by this paper
• Function and structure of heterodimeric amino acid transporters.

  2001cited by this paper
• The uptake of cysteine in cultured primary astrocytes and neurons.

  2001cited by this paper
• New flavanol derivatives from grape (Vitis vinifera) byproducts. Antioxidant aminoethylthio-flavan-3-ol conjugates from a polymeric waste fraction used as a source of flavanols.

  2001cited by this paper
• L‐lactate inhibits L‐cystine/L‐glutamate exchange transport and decreases glutathione content in rat cultured astrocytes

  2000cited by this paper
• Ischemic cell death in brain neurons.

  1999cited by this paper
• Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

  1999cited by this paper
• Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins*

  1999cited by this paper
• Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?

  1998cited by this paper
• Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death.

  1997cited by this paper
• Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter*

  1996cited by this paper
• Promotion of cyst(e)ine uptake.

  1995cited by this paper
• [11] Promotion of cyst(e)ine uptake

  1995influential reference
• Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.

  1994cited by this paper
• Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.

  1994cited by this paper
• Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.

  1993cited by this paper
• Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine.

  1992cited by this paper
• Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress.

  1989cited by this paper
• Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill.

  1989cited by this paper
• Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine.

  1988cited by this paper
• Glutathione.

  1983cited by this paper
• Mechanism of growth stimulation of L1210 cells by 2-mercaptoethanol in vitro. Role of the mixed disulfide of 2-mercaptoethanol and cysteine.

  1981cited by this paper
• Role of proton dissociation in the transport of cystine and glutamate in human diploid fibroblasts in culture.

  1981cited by this paper
• Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.

  1980cited by this paper
• Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

  1979cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper
• Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.

  1969cited by this paper

• Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment

  2022cites this paper
• Use of antioxidants to augment semen efficiency during liquid storage and cryopreservation in livestock animals: A review

  2021cites this paper
• Thiols: Role in Oxidative Stress-Related Disorders

  2021cites this paper
• Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

  2020cites this paper
• Statin administration activates System Xc- in skeletal muscle: a potential mechanism explaining statin-induced muscle pain.

  2019cites this paper
• Antioxidants and Periodontal Diseases

  2019cites this paper
• Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells

  2019cites this paper
• Molecular cloning, tissue distribution and the expression of cystine/glutamate exchanger (xCT, SLC7A11) in different tissues during development in broiler chickens

  2019cites this paper
• Cysteamine Protects Neurons from Mutant Huntingtin Toxicity

  2019cites this paper
• Current Concepts in Pediatric Nonalcoholic Fatty Liver Disease.

  2017cites this paper
• Methylglyoxal‐induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells

  2017cites this paper
• In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores.

  2016cites this paper
• Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells.

  2015cites this paper
• Oxidative Stress in Cornea

  2015cites this paper
• The Importance of Oxidative Stress in Early Week Pregnancy Losses

  2014cites this paper
• Physicochemical and toxicological characterization of sucrose-bound polynuclear iron oxyhydroxide formulations

  2014cites this paper
• Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

  2014cites this paper
• Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSHDelivery Systems

  2014cites this paper
• Phosphoinositide 3-Kinases Upregulate System xc − via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

  2014cites this paper
• Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery

  2014cites this paper
• Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

  2013cites this paper
• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

  2013cites this paper
• Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin.

  2013cites this paper
• Glutathione metabolism and Parkinson's disease.

  2013cites this paper
• Emerging drugs for non-alcoholic steatohepatitis

  2013cites this paper
• Oxidant/antioxidant equilibrium in rats supplemented with diesel fuel or with opium poppy (Papaver somniferum L.) seed oil biodiesel.

  2013cites this paper
• High electron transfer capacity of thio-derivatives of tea catechins measured using a water soluble stable free radical and their effects on colon cancer cells

  2013cites this paper
• Cysteine Dependence of Insulin-like Growth Factor Effects on Redox and Methylation Status

  2012cites this paper
• The effect of cysteamine bitartrate on adiponectin multimerization in non-alcoholic fatty liver disease and healthy subjects.

  2012cites this paper
• Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

  2012cites this paper
• Reactive astrocytes give neurons less support: implications for Alzheimer's disease.

  2012cites this paper
• EXPRESSION OF PORCINE INTESTINAL NUTRIENT TRANSPORTERS ALONG CRYPT-VILLUS AXIS AND DURING POSTNATAL DEVELOPMENT

  2011cites this paper
• Effect of Cysteamine on Oxidative Stress-induced Cell Death of Human Corneal Endothelial Cells

  2011cites this paper
• Cysteamine suppresses human peripheral blood mononuclear cells – human corneal endothelial cell reaction via reactive oxygen species reduction

  2011cites this paper
• Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

  2011cites this paper
• Enteric‐coated cysteamine for the treatment of paediatric non‐alcoholic fatty liver disease

  2011cites this paper
• Effect of proinflammatory activation on the neurosupportive functions of astrocytes

  2011cites this paper
• Absorption and Metabolization of Cytoprotective Epicatechin Thio-Conjugates in Rats

  2010cites this paper
• Absorption and Metabolization of Cytoprotective Epicatechin Thio Conjugates in Rats

  2010cites this paper
• Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.

  2010cites this paper
• Absorption and Metabolization of Cytoprotective Epicatechin Thio-Conjugates in Rats

  2010influential citation
• Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles?

  2010cites this paper
• Comparison of the renal, cardiovascular and hepatic toxicity data of original intravenous iron compounds.

  2010cites this paper
• Melatonin and Reproduction Revisited

  2009cites this paper
• Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression*

  2009cites this paper
• Differences Between Original Intravenous Iron Sucrose and Iron Sucrose Similar Preparations

  2009cites this paper
• Caracterización de derivados polifenólicos obtenidos de fuentes naturales. Citotoxicidad y capacidad antioxidante frente a estrés oxidativo en modelos celulares

  2009cites this paper
• Biobased epicatechin conjugates protect erythrocytes and nontumoral cell lines from H2O2-induced oxidative stress.

  2009cites this paper