Glutathione metabolism and its implications for health.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of NutriLife

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JN/134.3.489PMID 14988435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of influenza infection by glutathione.

  2003cited by this paper
• Effect of glutamine on glutathione, IGF-I, and TGF-β1

  2003cited by this paper
• Mitochondrial formation of reactive oxygen species

  2003cited by this paper
• Regulative capacity of glutamine

  2003cited by this paper
• Nitric Oxide Triggers the Toxicity due to Glutathione Depletion in Midbrain Cultures through 12-Lipoxygenase*

  2003cited by this paper
• Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action.

  2003cited by this paper
• Cellular redox: a modulator of intestinal epithelial cell proliferation.

  2003cited by this paper
• Effect of glutamine on glutathione, IGF-I, and TGF-beta 1.

  2003cited by this paper
• Heme oxygenase‐1 induction by endogenous nitric oxide: influence of intracellular glutathione

  2003cited by this paper
• The importance of glutathione in human disease.

  2003influential reference
• Redox potential of GSH/GSSG couple: assay and biological significance.

  2002cited by this paper
• Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

  2002cited by this paper
• II. Glutamine and glutamate.

  2002cited by this paper
• Cysteine metabolism in periportal and perivenous hepatocytes: Perivenous cells have greater capacity for glutathione production and taurine synthesis but not for cysteine catabolism

  2002cited by this paper
• Net interorgan transport of L-glutamate in rats occurs via the plasma, not via erythrocytes.

  2002cited by this paper
• In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice.

  2002cited by this paper
• Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition.

  2002cited by this paper
• Regulation of nitric oxide synthesis by dietary factors.

  2002cited by this paper
• Free radicals, antioxidants, and nutrition.

  2002cited by this paper
• Cooperative Binding of γ-Glutamyl Substrate to Human Glutathione Synthetase☆

  2001cited by this paper
• Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase.

  2001cited by this paper
• In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition.

  2000cited by this paper
• Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet.

  2000influential reference
• Regulation of glutathione synthesis.

  2000cited by this paper
• Cellular thiols and redox-regulated signal transduction.

  2000cited by this paper
• Erythrocyte glutathione deficiency in symptom-free HIV infection is associated with decreased synthesis rate.

  1999cited by this paper
• Biologic and pharmacologic regulation of mammalian glutathione synthesis.

  1999influential reference
• Glutathione and its role in cellular functions.

  1999cited by this paper
• Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon.

  1998cited by this paper
• Enteral glutamate is the preferential source for mucosal glutathione synthesis in fed piglets.

  1997cited by this paper
• Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine.

  1996cited by this paper
• Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.

  1992cited by this paper
• L-2-oxothiazolidine-4-carboxylate as a cysteine precursor: efficacy for growth and hepatic glutathione synthesis in chicks and rats.

  1990cited by this paper

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