Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Pediatrics

• Publication date

  2009-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1542/peds.2007-3423PMID 19117861PMCID PMC2760222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new arenavirus in a cluster of fatal transplant-associated diseases.

  2008cited by this paper
• The new age of molecular diagnostics for microbial agents.

  2008cited by this paper
• The Roles of Bacteria and TLR4 in Rat and Murine Models of Necrotizing Enterocolitis1

  2006cited by this paper
• Empiric Use of Ampicillin and Cefotaxime, Compared With Ampicillin and Gentamicin, for Neonates at Risk for Sepsis Is Associated With an Increased Risk of Neonatal Death

  2006cited by this paper
• Reported Medication Use in the Neonatal Intensive Care Unit: Data From a Large National Data Set

  2006cited by this paper
• Very Low Birth Weight Preterm Infants With Early Onset Neonatal Sepsis: The Predominance of Gram-Negative Infections Continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002–2003

  2005cited by this paper
• An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

  2005cited by this paper
• Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight Infants After Necrotizing Enterocolitis

  2005cited by this paper
• Randomized Trial of Donor Human Milk Versus Preterm Formula as Substitutes for Mothers' Own Milk in the Feeding of Extremely Premature Infants

  2005cited by this paper
• Newer approaches to the diagnosis of early onset neonatal sepsis

  2005cited by this paper
• Prediction of Death for Extremely Low Birth Weight Neonates

  2005cited by this paper
• The Developing Intestinal Ecosystem: Implications for the Neonate

  2005cited by this paper
• Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

  2004cited by this paper
• Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.

  2004cited by this paper
• Duration of Empiric Antibiotics for Suspected Early-Onset Sepsis in Extremely Low Birth Weight Infants

  2003cited by this paper
• Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants.

  2003cited by this paper
• Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network.

  2001cited by this paper
• 超出生体重児に対する早期デキサメサゾン投与の有用性 : National Institute of Child Health and Human Development Neonatal research Network報告 (海外誌掲載論文の和文概要とそれに対するコメント)

  2001cited by this paper
• Rapid Detection of Microorganisms in Blood Cultures of Newborn Infants Utilizing an Automated Blood Culture System

  2000cited by this paper
• Stool microflora in extremely low birthweight infants

  1999cited by this paper
• National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units.

  1999cited by this paper
• Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994.

  1998cited by this paper
• Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial

  1997cited by this paper
• Volume of blood required to detect common neonatal pathogens.

  1996cited by this paper
• VOLUME OF BLOOD REQUIRED TO DETECT COMMON NEONATAL PATHOGENS †1442

  1996cited by this paper
• Use of the CRIB (clinical risk index for babies) score in prediction of neonatal mortality and morbidity.

  1995cited by this paper
• Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network.

  1991cited by this paper
• Gastrointestinal Colonization with Yeast Species and Candida Septicemia in Very Low Birth Weight Infants

  1990cited by this paper
• Time to positivity for detection of bacteremia in neonates

  1989cited by this paper
• Necrotizing Enterocolitis: Treatment Based on Staging Criteria

  1986cited by this paper

• Antibiotic exposure in culture-negative preterm infants: a 10-year single-centre study.

  2026cites this paper
• Surgical site infections in neonates: A contemporary review.

  2026cites this paper
• Brief early antibiotic exposure (≤2 days) is not associated with disruption of gut microbiome in very low birth weight infants

  2026cites this paper
• Protocol for developing a national approach to surveillance and prevention for neonatal ventilator-associated pneumonia

  2026cites this paper
• Presepsin to safely reduce antibiotics in preterm infants (PRESAFE): study protocol for a randomized controlled trial with a concurrent observational study.

  2026cites this paper
• Variation in neonatal antibiotic management for patients undergoing fetal myelomeningocele repair across Children's Hospitals Neonatal Consortium (CHNC) centers.

  2026cites this paper
• Duration of Antibiotic Therapy for Gram-Negative Bloodstream Infections in the Neonatal Intensive Care Unit.

  2026cites this paper
• Rapid Detection of Inter-alpha Inhibitor Proteins in Neonatal Sepsis and Necrotizing Enterocolitis

  2026cites this paper
• The Angel in the Marble: Antibiotic Duration in the Neonatal Intensive Care Unit.

  2026cites this paper
• Duration of Antibiotic Therapy for Escherichia coli Bacteremia in Infants With Normal Cerebrospinal Fluid Studies and Without Meningitis.

  2026cites this paper
• Gut microbiota immaturity with DL-endopeptidase deficiency links antibiotic use to preterm late-onset sepsis.

  2026cites this paper
• Outcomes and antimicrobial usage in preterm neonates < 34 weeks gestation with culture-negative neonatal sepsis: a prospective observational study

  2025cites this paper
• Reducing Antibiotic Use for Culture-Negative Sepsis in a Level IV Neonatal Intensive Care Unit.

  2025cites this paper
• Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol

  2025cites this paper
• Theoretical impact of a bedside decision-making tool on antibiotic use for suspected neonatal healthcare-associated infection: an observational study

  2025cites this paper
• Preterm prelabour rupture of membranes: the use of amniocentesis to detect intra-amniotic infection reduces maternal and neonatal duration of antibiotic exposure.

  2025cites this paper
• Neonatal Mucormycosis: A Rare but Highly Lethal Fungal Infection in Term and Preterm Newborns—A 20-Year Systematic Review

  2025cites this paper
• Early Effective Antibiotic Therapy and Meningitis following a Bloodstream Infection in Hospitalized Infants: A Cohort Study

  2025cites this paper
• Serial physical examination to reduce unnecessary antibiotic exposure in newborn infants: a population-based study

  2025cites this paper
• Neonatal Sepsis: Etiology, Antimicrobial Susceptibility, and Treatment Outcomes in a Tertiary Hospital in Jos, Nigeria

  2025cites this paper
• Does the duration of empiric antibiotic treatment influence NEC incidence and severity relative to placental pathology?

  2025cites this paper
• Neonatology: First Exposure to Antibiotics from the Ethical Perspective of Parents, Physicians, and Regulators

  2025cites this paper
• Gut microbiota in necrotizing enterocolitis: a bibliometric and visualization analysis.

  2025cites this paper
• The association of early antibiotic exposure with subsequent development of late-onset sepsis in preterm infants: a systematic review and meta-analysis studies

  2025cites this paper
• Neonatal microbiome in the multiomics era: development and its impact on long-term health

  2025cites this paper
• Effect of early antibiotic exposure on necrotizing enterocolitis and growth in extremely preterm infants

  2025cites this paper
• Epidemiology, etiology and risk factors of culture confirmed, nosocomial late onset neonatal sepsis in Western Mexico

  2025cites this paper
• Association of Placental Pathology and Antibiotic Exposure after Birth with the Severity of Necrotizing Enterocolitis in Preterm Infants: A Case–Control Study

  2025cites this paper
• Bone marrow-derived mesenchymal stromal cells in necrotizing enterocolitis treatment: a narrative review

  2025cites this paper
• Consequences of host-microbiome interactions in preterm infants

  2025cites this paper
• New Insight into The Use of Prophylactic Probiotic Supplement in Preterm and Very Low Birth Weight Infants

  2025cites this paper
• Point of care v/s central lab automated blood culture system in decreasing antibiotic usage in NICU: A randomized controlled trial

  2025influential citation
• Association of Placental Pathology and antibiotic exposure after birth with the Severity of Necrotizing Enterocolitis in Preterm infants - A Matched Case-Control Study

  2025cites this paper
• Absence of association between early antibiotic exposure and short-term adverse outcomes in very preterm infants: a single-center retrospective study

  2025cites this paper
• Early antibiotic exposure and necrotizing enterocolitis among preterm infants < 34 weeks’ gestation

  2025cites this paper
• Demystifying Prolonged Antibiotic Use for Blood Culture-negative Sepsis Evaluations in the Neonatal Intensive Care Unit.

  2025cites this paper
• Early antibiotic exposure and the risk of necrotizing enterocolitis in preterm neonates: insights from a large multicenter cohort in China

  2025cites this paper
• Clinical, scientific and healthcare system consequences of misdiagnosing neonatal sepsis

  2025cites this paper
• Dysbiotic Microbiota in Necrotizing Enterocolitis: Insights into Pathogenesis, Treatment, and Prevention.

  2025cites this paper
• Pediatric stewardship in Italy: a necessity, not an option - a National Multi-Society Expert Consensus on Antimicrobial and Diagnostic Stewardship (SIP, SITIP, SIMRI, SIAIP, SIMEUP, SIPPS, SICUPP, SIMIT, SIMPE, SIPINF, SIT, SIAATIP, SARNEPI, AIEOP, SIM, SITI, SIF, SIFACT, SITA, SIN)

  2025cites this paper
• Neonatal enteral antibiotics reduce gut inflammation and delay systemic immune development in preterm pigs.

  2025cites this paper
• Gut Microbiota and Neurodevelopment in Preterm Infants: Mechanistic Insights and Prospects for Clinical Translation

  2025cites this paper
• Perioperative Nutrition in Pediatric Patients with Congenital Heart Disease and Heart Failure

  2025cites this paper
• What Is the Role of Antibiotic Stewardship in the NICU?

  2025cites this paper
• Risk Factors for Health Care–Associated Bloodstream Infections in NICUs

  2025cites this paper
• Elimination of Candida Sepsis and Reducing Several Morbidities in a Tertiary NICU in Greece After Changing Antibiotic, Ventilation, and Nutrition Protocols

  2025cites this paper
• Development of a Predictive Model for Neonatal Hospital-Acquired Gastrointestinal Infections Utilizing Multiple Machine Learning Algorithms

  2025cites this paper
• Bacterial DNA detection in blood using PCR/ESI-MS in neonates with suspected early onset infection

  2025cites this paper
• Molecular Characterization of a Rare ESBL E. coli Strain Causing a Necrotizing Enterocolitis Outbreak in Preterm Infants.

  2025cites this paper
• Use of Antibiotics and Severe Bacterial Infections Within the First 6 Months of Life—A Population‐Based Cohort Study From East Denmark

  2025cites this paper
• The double-edged sword of early antibiotic exposure in extremely preterm infants: implications for necrotizing enterocolitis and growth faltering

  2025cites this paper
• Gram-Negative Colonization and Bacterial Translocation Drive Neonatal Sepsis in the Indian Setting

  2024cites this paper
• Assessing Diagnostic Performance of Molecular Culture for Neonatal Sepsis: Protocol of the CHAMPIONS Study

  2024cites this paper
• Improved use of antibiotics following implementation of antimicrobial stewardship in a neonatal intensive care unit

  2024cites this paper
• Antibiotic use among extremely low birth-weight infants from 2009 to 2021: a retrospective observational study

  2024cites this paper
• [A quality improvement project on reducing antibiotic use duration in very low birth weight preterm infants in the neonatal intensive care unit].

  2024cites this paper
• Immunological aspects of necrotizing enterocolitis models: a review

  2024cites this paper
• Efficacy of short‐course antibiotics for culture‐positive neonatal sepsis: A systematic review and meta‐analysis

  2024cites this paper
• Shorter versus longer duration antibiotic regimens for treatment of culture-positive neonatal sepsis.

  2024cites this paper
• Shorter versus longer duration antibiotic regimens for treatment of suspected neonatal sepsis.

  2024cites this paper
• Regulation of intestinal epithelial homeostasis by mesenchymal cells

  2024cites this paper
• Blood volume collected for cultures in infants with suspected neonatal sepsis

  2024cites this paper
• High cumulative antibiotic exposure in extremely low birth weight infants during the first month of life: Risk factors and clinical outcomes.

  2024cites this paper
• Time to positivity of blood cultures in a level IV NICU varies based on organism category and population subgroups: is a 36-hour rule out safe?

  2024cites this paper
• Photoacoustic imaging for non-invasive assessment of biomarkers of intestinal injury in experimental necrotizing enterocolitis

  2024cites this paper
• The gut microbiome, resistome, and mycobiome in preterm newborn infants and mouse pups: lack of lasting effects by antimicrobial therapy or probiotic prophylaxis

  2024cites this paper
• Antibiotic Stewardship in the Neonatal Intensive Care Unit

  2024cites this paper
• Ultrasound role in diagnosis and as an assisting tool in prognostication of surgery in neonates with Necrotizing Enterocolitis

  2024cites this paper
• Newer Insights in Etiology and Pathogenesis of Neonatal Sepsis

  2024cites this paper
• Fulfilling the Promise of the Premise in Neonatal Antimicrobial Stewardship.

  2024cites this paper
• Umbilical arterial catheter duration as risk factor for Bell's Stage III necrotizing enterocolitis in preterm neonates

  2024cites this paper
• Nosocomial Infections in the Neonatal Intensive Care Unit.

  2024cites this paper
• The Potential of Fecal Volatile Organic Compound Analysis for the Early Diagnosis of Late-Onset Sepsis in Preterm Infants: A Narrative Review

  2024cites this paper
• Early Antibiotic Exposure and Bronchopulmonary Dysplasia in Very Preterm Infants at Low Risk of Early-Onset Sepsis

  2024cites this paper
• Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem

  2024cites this paper
• Prevention Strategies and Management of Necrotizing Enterocolitis

  2024cites this paper
• Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention

  2024influential citation
• Umbilical cord blood culture for early onset sepsis in preterm infants

  2024cites this paper
• Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis

  2024cites this paper
• [A cross-sectional study on the pathogen composition and antimicrobial resistance in neonates with sepsis in Hebei Province, China].

  2024cites this paper
• Wide use of broad-spectrum antibiotics in very low birth weight infants with spontaneous focal intestinal perforation—is it really justified?

  2024cites this paper
• The hidden threat: Environmental toxins and their effects on gut microbiota.

  2024cites this paper
• Unexplained gut symptoms in extremely preterm infants are associated with gastrointestinal dysfunction at 5.5 years

  2024cites this paper
• Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection

  2024cites this paper
• Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test

  2024cites this paper
• Comparing two different Protocols in Withholding Feeds around time of Packed Red Cell Transfusion and Occurrence of TANEC (Transfusion Associated Necrotizing Enterocolitis) in Preterm Neonates

  2024cites this paper
• 28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use

  2024cites this paper
• The “pro” and “con” of probiotics, regulation and preterm infant health

  2024cites this paper
• Multidrug-Resistant Bacterial Infections Among Very Low Birthweight Infants With Late-Onset Sepsis in Johannesburg, South Africa

  2023cites this paper
• Influence of infant microbiome on health and development

  2023cites this paper
• Association of delivery risk phenotype with early-onset sepsis in preterm infants

  2023cites this paper
• Short-course antibiotic therapy for pneumonia in the neonatal intensive care unit

  2023cites this paper
• Preterm pigs for preterm birth research: reasonably feasible

  2023cites this paper
• Necrotizing enterocolitis, gut microbes, and sepsis

  2023cites this paper
• Decreasing Antibiotic Use in a Community Neonatal Intensive Care Unit: A Quality Improvement Initiative

  2023cites this paper
• The Detrimental Effects of Peripartum Antibiotics on Gut Proliferation and Formula Feeding Injury in Neonatal Mice Are Alleviated with Lactobacillus rhamnosus GG

  2023cites this paper
• Special Populations-Surgical Infants.

  2023cites this paper
• Antibiotics Use and Its Effects on the Establishment of Feeding Tolerance in Preterm Neonates

  2023cites this paper
• Early antibiotic exposure in very-low birth weight infants and infection risk at 3–7 days after birth

  2023cites this paper
• Gut pathogen colonization precedes bloodstream infection in the neonatal intensive care unit

  2023cites this paper