Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature Medicine

• Publication date

  2007-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nm1548PMID 17351625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The GM2 Gangliosidoses

  2007cited by this paper
• Acute injury directs the migration, proliferation, and differentiation of solid organ stem cells: evidence from the effect of hypoxia-ischemia in the CNS on clonal "reporter" neural stem cells.

  2006cited by this paper
• Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury.

  2006cited by this paper
• Oligodendroglial Progenitor Cell Therapy Limits Central Neurological Deficits in Mice with Metachromatic Leukodystrophy

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• The therapeutic potential of neural stem/progenitor cells in murine globoid cell leukodystrophy is conditioned by macrophage/microglia activation.

  2006cited by this paper
• Effective gene therapy in an authentic model of Tay-Sachs-related diseases

  2006cited by this paper
• Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes

  2006cited by this paper
• Screening for lysosomal disorders

  2005cited by this paper
• Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells

  2005cited by this paper
• More than just proliferation: Myc function in stem cells.

  2005cited by this paper
• Expression profile of an operationally-defined neural stem cell clone.

  2005cited by this paper
• Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice.

  2005cited by this paper
• Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro

  2005cited by this paper
• LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism

  2005cited by this paper
• Development of functional human embryonic stem cell-derived neurons in mouse brain.

  2005cited by this paper
• Neural stem cells and neurospheres—re-evaluating the relationship

  2005cited by this paper
• Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease.

  2004cited by this paper
• Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

  2004cited by this paper
• N‐butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis

  2004cited by this paper
• Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice.

  2004cited by this paper
• Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling.

  2004cited by this paper
• NSAIDs increase survival in the Sandhoff disease mouse: Synergy with N‐butyldeoxynojirimycin

  2004cited by this paper
• Isolation and characterization of neural progenitor cells from post‐mortem human cortex

  2003cited by this paper
• Neural Stem Cells: An Overview

  2003cited by this paper
• Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

  2003cited by this paper
• Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.

  2003cited by this paper
• Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

  2002cited by this paper
• Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling.

  2002cited by this paper
• The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

  2002cited by this paper
• N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.

  2002cited by this paper
• The Metabolic and Molecular Bases of Inherited Disease

  2001cited by this paper
• Neural progenitors from human embryonic stem cells

  2001cited by this paper
• Segregation of Human Neural Stem Cells in the Developing Primate Forebrain

  2001cited by this paper
• In vitro differentiation of transplantable neural precursors from human embryonic stem cells

  2001cited by this paper
• Enrichment of neurons and neural precursors from human embryonic stem cells.

  2001cited by this paper
• Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation.

  2000cited by this paper
• Stemming the tide: glycosphingolipid synthesis inhibitors as therapy for storage diseases.

  2000cited by this paper
• Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin.

  1999cited by this paper
• Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

  1998cited by this paper
• Bootstrap Methods and Their Application

  1998cited by this paper
• Quantification without pontification: Choosing a method for counting objects in sectioned tissues

  1997cited by this paper
• Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease.

  1997cited by this paper
• Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin.

  1997cited by this paper
• Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action.

  1997cited by this paper
• Expression of human β–hexosaminidase α–subunit gene (the gene defect of Tay–Sachs disease) in mouse brains upon engraftment of transduced progenitor cells

  1996cited by this paper
• Mice lacking both subunits of lysosomal β–hexosaminidase display gangliosidosis and mucopolysaccharidosis

  1996cited by this paper
• Expression of human beta-hexosaminidase alpha-subunit gene (the gene defect of Tay-Sachs disease) in mouse brains upon engraftment of transduced progenitor cells.

  1996cited by this paper
• Methods for determining numbers of cells and synapses: A case for more uniform standards of review

  1996cited by this paper
• Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain.

  1995cited by this paper
• Neural progenitor cell engraftment corrects lysosomal storage throughout the MRS VII mouse brain

  1995cited by this paper
• Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy

  1993cited by this paper
• Release of β-hexosaminidase isoenzymes in cultured human fibroblasts

  1993cited by this paper
• Release of beta-hexosaminidase isoenzymes in cultured human fibroblasts.

  1993cited by this paper
• Techniques in diagnostic human biochemical genetics

  1991cited by this paper
• A Laboratory manual

  1989cited by this paper
• Partial enzyme deficiencies: residual activities and the development of neurological disorders.

  1983cited by this paper

• The future of clinical studies of in-utero therapy for genetic diseases.

  2025cites this paper
• The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS

  2025cites this paper
• Therapeutic genetic restoration through allogeneic brain microglia replacement

  2025cites this paper
• Single‐Cell Analysis of L‐Myc Expressing Neural Stem Cells and Their Extracellular Vesicles Revealed Distinct Progenitor Populations With Neurogenic Potential

  2025cites this paper
• A systematic review of lifespan studies in rodents using stem cell transplantations.

  2024cites this paper
• Human neural stem cell–derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

  2024cites this paper
• Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment.

  2023cites this paper
• Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury

  2023cites this paper
• Therapeutic Potential of Chinese Medicine for Endogenous Neurogenesis: A Promising Candidate for Stroke Treatment

  2023cites this paper
• Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury

  2023cites this paper
• Reduced dopaminergic neuron degeneration and global transcriptional changes in Parkinson's disease mouse brains engrafted with human neural stems during the early disease stage.

  2022cites this paper
• Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

  2022cites this paper
• Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease

  2022cites this paper
• An In Vivo Platform for Rebuilding Functional Neocortical Tissue

  2022cites this paper
• Isolation and Culture of Neural Stem/Progenitor Cells from the Postnatal Periventricular Region.

  2022cites this paper
• Targeting the Central Nervous System in Lysosomal Storage Diseases: Strategies to Deliver Therapeutics Across the Blood-Brain Barrier.

  2022cites this paper
• Sphingolipid lysosomal storage diseases: from bench to bedside

  2021influential citation
• Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

  2021cites this paper
• Stem Cell Applications in Lysosomal Storage Disorders: Progress and Ongoing Challenges.

  2021cites this paper
• Modulation of gene expression on a transcriptome-wide level following human neural stem cell transplantation in aged mouse stroke brains.

  2021influential citation
• Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis

  2021cites this paper
• Shikonin regulates autophagy via the AMPK/mTOR pathway and reduces apoptosis of human umbilical cord mesenchymal stem cells to improve survival in tissues surrounding brain contusion

  2021cites this paper
• Neural Stem Cells for Early Ischemic Stroke

  2021cites this paper
• An Engineered sgsh Mutant Zebrafish Recapitulates Molecular and Behavioural Pathobiology of Sanfilippo Syndrome A/MPS IIIA

  2021cites this paper
• Prospects of Therapeutic Target and Directions for Ischemic Stroke

  2021cites this paper
• Shear-Resistant, Biological Tethering of Nanostimulators for Enhanced Therapeutic Cell Paracrine Factor Secretion.

  2021cites this paper
• New Avenues for the Treatment of Huntington’s Disease

  2021cites this paper
• KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

  2021cites this paper
• Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned.

  2021cites this paper
• Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice

  2020cites this paper
• Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration

  2020influential citation
• “Reprogram Enablement” as an Assay for Identifying Early Oncogenic Pathways by Their Ability to Allow Neoplastic Cells to Reacquire an Epiblast State

  2020cites this paper
• Stem Cell Therapy& Its Application in Neurological Conditions A Review

  2020cites this paper
• Pronounced Therapeutic Benefit of a Single Bidirectional AAV Vector Administered Systemically in Sandhoff Mice.

  2020cites this paper
• Neuroregeneration: Regulation in Neurodegenerative Diseases and Aging

  2020cites this paper
• Human neural stem cells improve early stage stroke outcome in delayed tissue plasminogen activator-treated aged stroke brains.

  2020cites this paper
• Prenatal transplantation of human amniotic fluid stem cell could improve clinical outcome of type III spinal muscular atrophy in mice

  2020cites this paper
• Dietary phytochemical approaches to stem cell regulation

  2020cites this paper
• Application of Stem Cells in Stroke: A Multifactorial Approach

  2020cites this paper
• A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury.

  2020cites this paper
• Haematopoietic stem cell gene therapy with IL‐1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

  2020cites this paper
• Editorial of special issue: Blood-CNS and blood-nerve barriers in health and diseases and potential therapy.

  2020cites this paper
• Neural stem cell therapy for neurovascular injury in Alzheimer's disease.

  2019cites this paper
• Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy

  2019cites this paper
• Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury

  2019cites this paper
• D-mannose-Coating of Maghemite Nanoparticles Improved Labeling of Neural Stem Cells and Allowed Their Visualization by ex vivo MRI after Transplantation in the Mouse Brain

  2019cites this paper
• The state of the art in stem cell biology and regenerative medicine: the end of the beginning

  2018cites this paper
• Engineering the Surface of Therapeutic "Living" Cells.

  2018cites this paper
• Neural stem cell therapy for subacute and chronic ischemic stroke

  2018cites this paper
• Interactions Between Neural Progenitor Cells and Microglia in the Subventricular Zone: Physiological Implications in the Neurogenic Niche and After Implantation in the Injured Brain

  2018cites this paper
• Suppression of NK and CD8+ T cells reduces astrogliosis but accelerates cerebellar dysfunction and shortens life span in a mouse model of Sandhoff disease.

  2017cites this paper
• Biobridge concept in stem cell therapy for ischemic stroke.

  2017cites this paper
• Stem Cell-Induced Biobridges as Possible Tools to Aid Neuroreconstruction after CNS Injury

  2017influential citation
• 6 – Stem Cell Biology

  2017cites this paper
• Haematopoietic Stem Cell Transplantation Arrests the Progression of Neurodegenerative Disease in Late-Onset Tay-Sachs Disease.

  2017cites this paper
• 15 – Stem Cell Transplantation for Childhood Neurologic Disorders

  2017cites this paper
• Embryogenesis and Regeneration of the Intervertebral Disk (Review)

  2017cites this paper
• Progenitor cell-based treatment of glial disease.

  2017cites this paper
• Intraspinal administration of human spinal cord‐derived neural progenitor cells in the G93A–SOD1 mouse model of ALS delays symptom progression, prolongs survival and increases expression of endogenous neurotrophic factors

  2017cites this paper
• Exogenous stem cells pioneer a biobridge to the advantage of host brain cells following stroke: New insights for clinical applications

  2017cites this paper
• ДЕГЕНЕРАЦИЯ МЕЖПОЗВОНКОВОГО ДИСКА И ВОЗМОЖНОСТИ ТКАНЕВОЙ ИНЖЕНЕРИИ: ОБЗОР ЛИТЕРАТУРЫ

  2017cites this paper
• Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

  2017cites this paper
• Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage

  2017cites this paper
• Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice

  2017cites this paper
• Delayed Umbilical Cord Clamping: A State of the Science

  2016cites this paper
• Glial progenitor cell-based treatment of the childhood leukodystrophies.

  2016cites this paper
• Cell Therapy for Pediatric Disorders of Glia

  2016cites this paper
• Generation of Human Induced Pluripotent Stem Cell‐Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy

  2016cites this paper
• Stem Cell Therapy for the Central Nervous System in Lysosomal Storage Diseases

  2016cites this paper
• Interneuron Progenitor Transplantation to Treat CNS Dysfunction

  2016cites this paper
• Neural Stem Cell Transplantation and CNS Diseases.

  2016cites this paper
• Biomaterial strategies for controlling stem cell fate via morphogen sequestration.

  2016cites this paper
• Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking.

  2016cites this paper
• Overcoming Toxicity from Transgene Overexpression Through Vector Design in AAV Gene Therapy for GM2 Gangliosidoses

  2016cites this paper
• Stem Cells Reduced Neuroinflammatory Response During the Process of Stroke

  2016cites this paper
• The GM1 and GM2 Gangliosidoses: Natural History and Progress toward Therapy.

  2016cites this paper
• Extracellular uridine diphosphate-mediated microglial inflammation in a mouse model of Sandhoff disease

  2016cites this paper
• Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis

  2016cites this paper
• Gene therapy for lysosomal storage disorders: a good start.

  2016cites this paper
• Role of IGF1R+ MSCs in modulating neuroplasticity via CXCR4 cross-interaction

  2016cites this paper
• In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells.

  2016cites this paper
• Personalized Pharmacoperones for Lysosomal Storage Disorder: Approach for Next-Generation Treatment.

  2016cites this paper
• Stem Cell Therapy for Ischemic Stroke

  2016cites this paper
• Bystander Effect Fuels Human Induced Pluripotent Stem Cell‐Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke

  2015cites this paper
• Thrombin/Matrix Metalloproteinase-9-Dependent SK-N-SH Cell Migration is Mediated Through a PLC/PKC/MAPKs/NF-κB Cascade

  2015cites this paper
• Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy.

  2015cites this paper
• Enhancement by Uridine Diphosphate of Macrophage Inflammatory Protein-1 Alpha Production in Microglia Derived from Sandhoff Disease Model Mice.

  2015cites this paper
• A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I

  2015cites this paper
• Combined gene/cell therapies provide long-term and pervasive rescue of multiple pathological symptoms in a murine model of globoid cell leukodystrophy

  2015cites this paper
• Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

  2015cites this paper
• AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System

  2015cites this paper
• CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice

  2015cites this paper
• From Neurogenic Niche to Site of Injury: Stem Cell-Mediated Biobridge for Brain Repair

  2015cites this paper
• Engineering a Platform to Harness Pluripotent Stem Cell-Derived Paracrine Factors

  2015cites this paper
• The Application and Future of Neural Stem Cells in Regenerative Medicine

  2015cites this paper
• A possible new focus for stroke treatment – migrating stem cells

  2015cites this paper
• Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules

  2015cites this paper
• Ex vivo gene therapy for lysosomal storage disease using IPSC-derived neural stem cells

  2015cites this paper
• pathological symptoms in a murine model of globoid cell leukodystrophy

  2015cites this paper
• Reflectin as a Material for Neural Stem Cell Growth

  2015cites this paper