Human U2 snRNA Genes Exhibit a Persistently Open Transcriptional State and Promoter Disassembly at Metaphase

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular and Cellular Biology

• Publication date

  2008-03-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00087-08PMID 18378697PMCID PMC2423282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An Abundant Evolutionarily Conserved CSB-PiggyBac Fusion Protein Expressed in Cockayne Syndrome

  2008cited by this paper
• Transcriptional regulation of human small nuclear RNA genes.

  2008cited by this paper
• Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.

  2007cited by this paper
• Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates

  2007cited by this paper
• rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch.

  2007cited by this paper
• BRCA1 ubiquitinates RPB8 in response to DNA damage.

  2007cited by this paper
• A central role of the RNA polymerase trigger loop in active-site rearrangement during transcriptional pausing.

  2007cited by this paper
• Imaging Drosophila gene activation and polymerase pausing in vivo

  2007cited by this paper
• A transcription-independent role for TFIIB in gene looping.

  2007cited by this paper
• Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression

  2007cited by this paper
• Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

  2006cited by this paper
• Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.

  2006influential reference
• The Unorthodox SNAP50 Zinc Finger Domain Contributes to Cooperative Promoter Recognition by Human SNAPC*

  2006influential reference
• Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

  2006cited by this paper
• Heat shock transcription factor (Hsf)‐4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins

  2006cited by this paper
• Oxymoron no more: the expanding world of heterochromatic genes.

  2006cited by this paper
• UBF activates RNA polymerase I transcription by stimulating promoter escape

  2006cited by this paper
• Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.

  2006influential reference
• Mechanism of hsp70i Gene Bookmarking

  2005cited by this paper
• Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.

  2005cited by this paper
• Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

  2005influential reference
• P‐TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

  2005cited by this paper
• BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

  2005cited by this paper
• Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant.

  2005cited by this paper
• Nature of the nucleosomal barrier to RNA polymerase II.

  2005cited by this paper
• Crosstalk in gene expression: coupling and co-regulation of rDNA transcription, pre-ribosome assembly and pre-rRNA processing.

  2005cited by this paper
• Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage

  2004cited by this paper
• Potassium bromate but not X-rays cause unexpectedly elevated levels of DNA breakage similar to those induced by ultraviolet light in Cockayne syndrome (CS-B) fibroblasts

  2004cited by this paper
• Transcriptional Coactivator PC4 Stimulates Promoter Escape and Facilitates Transcriptional Synergy by GAL4-VP16

  2004cited by this paper
• Role of the C-Terminal Domain of RNA Polymerase II in U2 snRNA Transcription and 3′ Processing

  2004cited by this paper
• Gene regulation and DNA damage in the ageing human brain

  2004cited by this paper
• BRCA1 Can Modulate RNA Polymerase II Carboxy-Terminal Domain Phosphorylation Levels

  2004cited by this paper
• Constitutive DNase I Hypersensitivity of p53-Regulated Promoters*

  2003cited by this paper
• The 3′ ends of human pre‐snRNAs are produced by RNA polymerase II CTD‐dependent RNA processing

  2003cited by this paper
• A single-stranded promoter for RNA polymerase III

  2003cited by this paper
• Strange bedfellows: polyadenylation factors at the promoter.

  2003influential reference
• The C‐terminal domain of pol II and a DRB‐sensitive kinase are required for 3′ processing of U2 snRNA

  2003cited by this paper
• Interaction of proteins with promoter elements of the human U2 snRNA genes in vivo.

  2003influential reference
• The spliceosome: the most complex macromolecular machine in the cell?

  2003cited by this paper
• Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution.

  2002cited by this paper
• Association of human TFIID–promoter complexes with silenced mitotic chromatin in vivo

  2002cited by this paper
• Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.

  2002cited by this paper
• CSB is a component of RNA pol I transcription.

  2002cited by this paper
• SWI/SNF Complex Interacts with Tumor Suppressor p53 and Is Necessary for the Activation of p53-mediated Transcription*

  2002cited by this paper
• A Senior Thesis

  2002cited by this paper
• Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution

  2002cited by this paper
• BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

  2002cited by this paper
• RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase

  2002cited by this paper
• Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.

  2001cited by this paper
• A Map of Protein-Protein Contacts within the Small Nuclear RNA-activating Protein Complex SNAPc *

  2001cited by this paper
• Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

  2001cited by this paper
• The RNA polymerase III transcription apparatus.

  2001cited by this paper
• A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.

  2001cited by this paper
• c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism*

  2001cited by this paper
• RNA Polymerase III Transcription Complexes on Chromosomal 5S rRNA Genes In Vivo: TFIIIB Occupancy and Promoter Opening

  2001cited by this paper
• Small Nuclear RNA Genes: a Model System to Study Fundamental Mechanisms of Transcription*

  2001influential reference
• ATP-Dependent Chromatin Remodeling by the Cockayne Syndrome B DNA Repair-Transcription-Coupling Factor

  2000cited by this paper
• BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells.

  2000cited by this paper
• Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes.

  2000influential reference
• Distinct Roles for the Helicases of TFIIH in Transcript Initiation and Promoter Escape*

  2000influential reference
• In vivo footprinting studies suggest a role for chromatin in transcription of the human 7SK gene.

  2000cited by this paper
• Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation.

  2000cited by this paper
• Cockayne syndrome and xeroderma pigmentosum

  2000cited by this paper
• Striking bimodal methylation of the repeat unit of the tandem array encoding human U2 snRNA (the RNU2 locus).

  1999cited by this paper
• DNA distortion as a factor in nucleosome positioning.

  1999cited by this paper
• Coexpression of the adenovirus 12 E1B 55 kDa oncoprotein and cellular tumor suppressor p53 is sufficient to induce metaphase fragility of the human RNU2 locus.

  1999cited by this paper
• Inactivation of Both RNA Binding and Aconitase Activities of Iron Regulatory Protein-1 by Quinone-induced Oxidative Stress*

  1999influential reference
• Reactivity of potassium permanganate and tetraethylammonium chloride with mismatched bases and a simple mutation detection protocol.

  1999cited by this paper
• Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts.

  1999cited by this paper
• Concerted evolution of the tandem array encoding primate U2 snRNA (the RNU2 locus) is accompanied by dramatic remodeling of the junctions with flanking chromosomal sequences

  1999cited by this paper
• Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme.

  1999cited by this paper
• The General Transcription Factors IIA, IIB, IIF, and IIE Are Required for RNA Polymerase II Transcription from the Human U1 Small Nuclear RNA Promoter

  1999cited by this paper
• Transcription of the human U2 snRNA genes continues beyond the 3′ box in vivo

  1999influential reference
• Concerted evolution: molecular mechanism and biological implications.

  1999cited by this paper
• The Microsatellite Sequence (CT)n · (GA)nPromotes Stable Chromosomal Integration of Large Tandem Arrays of Functional Human U2 Small Nuclear RNA Genes

  1998cited by this paper
• c-Myc target gene specificity is determined by a post-DNAbinding mechanism.

  1998cited by this paper
• Characterization of a Novel Class of Interspersed LTR Elements in Primate Genomes: Structure, Genomic Distribution, and Evolution

  1998cited by this paper
• Adenovirus Type 12-Induced Fragility of the Human RNU2 Locus Requires p53 Function

  1998cited by this paper
• Metaphase fragility of the human RNU1 and RNU2 loci is induced by actinomycin D through a p53-dependent pathway.

  1998influential reference
• Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

  1998cited by this paper
• Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

  1998cited by this paper
• Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter.

  1998cited by this paper
• Promoter escape limits the rate of RNA polymerase II transcription and is enhanced by TFIIE, TFIIH, and ATP on negatively supercoiled DNA.

  1998cited by this paper
• Ligation-mediated PCR for chromatin-structure analysis of interphase and metaphase chromatin.

  1997cited by this paper
• Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion

  1997cited by this paper
• Structural analysis of mouse rDNA: coincidence between nuclease hypersensitive sites, DNA curvature and regulatory elements in the intergenic spacer.

  1997influential reference
• Analysis of chromatin structure by in vivo formaldehyde cross-linking.

  1997cited by this paper
• Marking of active genes on mitotic chromosomes

  1997cited by this paper
• Analysis of open complex formation during RNA polymerase II transcription initiation using heteroduplex templates and potassium permanganate probing.

  1997cited by this paper
• Facilitated recycling pathway for RNA polymerase III.

  1996influential reference
• Concerted evolution of the tandemly repeated genes encoding primate U2 small nuclear RNA (the RNU2 locus) does not prevent rapid diversification of the (CT)n.(GA)n microsatellite embedded within the U2 repeat unit.

  1995cited by this paper
• Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.

  1995influential reference
• Proximal sequence element-binding transcription factor (PTF) is a multisubunit complex required for transcription of both RNA polymerase II- and RNA polymerase III-dependent small nuclear RNA genes

  1995cited by this paper
• Balanced translocation in a neuroblastoma patient disrupts a cluster of small nuclear RNA UI and tRNA genes in chromosomal band Ip36

  1995cited by this paper
• Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements

  1995influential reference
• Substrate Specificity of Fpg Protein

  1994cited by this paper
• Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

  1994cited by this paper
• ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.

  1992influential reference
• Effects of different DNA polymerases in ligation-mediated PCR: enhanced genomic sequencing and in vivo footprinting.

  1992cited by this paper
• In vivo footprinting of a muscle specific enhancer by ligation mediated PCR.

  1990cited by this paper

• Mutational Selection: Fragile Sites, Replicative Stress, and Genome Evolution

  2025cites this paper
• A human supergene: BRCA1, CCDC200, and U2 snRNAs

  2025cites this paper
• The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions

  2023cites this paper
• The Mediator complex as a master regulator of transcription by RNA polymerase II

  2022cites this paper
• Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1

  2022cites this paper
• Merging established mechanisms with new insights: Condensates, hubs, and the regulation of RNA polymerase II transcription.

  2021cites this paper
• Small RNA Plays Important Roles in Virus–Host Interactions

  2020cites this paper
• RNA polymerase II transcribes snRNA genes

  2016cites this paper
• Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

  2015cites this paper
• Human snRNA genes use polyadenylation factors to promote efficient transcription termination

  2013cites this paper
• Functional Analysis of the Integrator Subunit 12 Identifies a Microdomain That Mediates Activation of the Drosophila Integrator Complex*

  2013cites this paper
• Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

  2013cites this paper
• Interaction between the Cockayne syndrome B and p53 proteins: implications for aging

  2012cites this paper
• Functional Analysis of Drosophila Integrator Complex in snRNA 3' End Processing

  2012cites this paper
• Procédé de détection et/ou de quantification de l'adn humain

  2011cites this paper
• Chromatin Structure Is Implicated in “Late” Elongation Checkpoints on the U2 snRNA and (cid:2) -Actin Genes (cid:1) §

  2009cites this paper
• Chromatin Structure Is Implicated in “Late” Elongation Checkpoints on the U2 snRNA and β-Actin Genes

  2009cites this paper