Non-Coding RNAs and Cancer

The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.

• Publication year

  2013

• Venue

  International Journal of Molecular Sciences

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms140817085PMID 23965974PMCID 3759953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Non-coding RNAs and Cancer

  2014cited by this paper
• MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer

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• The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.

  2013cited by this paper
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  2013cited by this paper
• Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines.

  2013cited by this paper
• Oncogene and Cancer - From Bench to Clinic

  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• eRNAs are required for p53-dependent enhancer activity and gene transcription.

  2013cited by this paper
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  2013cited by this paper
• Effect of miR-21 and miR-30b/c on TRAIL-induced apoptosis in glioma cells

  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• CpG island methylation status of miRNAs in esophageal squamous cell carcinoma

  2012cited by this paper
• Non-coding RNAs: key regulators of mammalian transcription.

  2012cited by this paper
• miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma.

  2012cited by this paper
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  2012cited by this paper
• The hallmarks of cancer

  2012cited by this paper
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  2012cited by this paper
• miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ

  2012cited by this paper
• MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521.

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• Silencing microRNA by interfering nanoparticles in mice

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Identification of human miRNA precursors that resemble box C/D snoRNAs

  2011cited by this paper
• Transcriptome Sequencing Identifies PCAT-1, a Novel lincRNA Implicated in Prostate Cancer Progression

  2011cited by this paper
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  2011cited by this paper
• Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

  2011cited by this paper
• Liposomal Delivery of MicroRNA-7–Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells

  2011cited by this paper
• Extensive and coordinated transcription of noncoding RNAs within cell cycle promoters

  2011cited by this paper
• Identification of piRNAs in the central nervous system.

  2011cited by this paper
• Gatekeepers for Piwi-piRNA complexes to enter the nucleus.

  2011cited by this paper
• The functional role of long non-coding RNA in human carcinomas

  2011cited by this paper
• microRNAs: Master regulators as potential therapeutics in cancer.

  2011cited by this paper
• MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest.

  2011cited by this paper
• Non-coding RNAs as regulators of embryogenesis

  2011cited by this paper
• miR‐605 joins p53 network to form a p53:miR‐605:Mdm2 positive feedback loop in response to stress

  2011cited by this paper
• miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

  2011cited by this paper
• HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer.

  2011cited by this paper
• Clinical significance of Hiwi gene expression in gliomas.

  2011cited by this paper
• No-nonsense functions for long noncoding RNAs.

  2011cited by this paper
• EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

  2011cited by this paper
• Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control

  2011cited by this paper
• Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.

  2011cited by this paper
• Widespread expression of piRNA-like molecules in somatic tissues

  2011cited by this paper
• PIWI-interacting small RNAs: the vanguard of genome defence

  2011cited by this paper
• Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment.

  2011cited by this paper
• The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis

  2011cited by this paper
• Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis

  2011cited by this paper
• SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer.

  2011cited by this paper
• Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Roles of small RNAs in tumor formation.

  2010cited by this paper
• Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

  2010cited by this paper
• Decoding the function of nuclear long non-coding RNAs.

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• Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor

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• Non‐coding RNAs: regulators of disease

  2010cited by this paper
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  2010cited by this paper
• Frequent Downregulation of miR-34 Family in Human Ovarian Cancers

  2010cited by this paper
• Long noncoding RNAs with enhancer-like function in human cells.

  2010cited by this paper
• Small RNA-mediated quiescence of transposable elements in animals.

  2010cited by this paper
• Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens

  2010cited by this paper
• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

  2010cited by this paper
• Negative regulation of tumor suppressor p53 by microRNA miR-504.

  2010cited by this paper

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• MicroRNA-224 Up-regulation: A Risk for Complications in Type 2 Diabetes Mellitus Egyptian Patients

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• The Biological Function of TUSC7/miR-1224-3p Axis in Triple-Negative Breast Cancer

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• Y Chromosome LncRNA Are Involved in Radiation Response of Male Non–Small Cell Lung Cancer Cells

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• Evidence of Y Chromosome Long Non-Coding RNAs involved in the Radiation Response of Male Non-Small Cell Lung Cancer Cells

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• Non-Coding RNAs and Cancer Gianpiero Di Leva and Michela Garofalo

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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2014cites this paper
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  2014cites this paper
• The Intertwining of Transposable Elements and Non-Coding RNAs

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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