Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Oncogene

• Publication date

  2001-06-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1204500PMID 11439338
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription

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  1998cited by this paper
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  1997influential reference
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer.

  1995cited by this paper
• Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes

  1995influential reference
• Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor.

  1995cited by this paper
• Cobalt stimulates the expression of vascular endothelial growth factor mRNA in rat cardiac cells.

  1994cited by this paper
• Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

  1992cited by this paper
• Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

  1990cited by this paper
• Requirement of the Na+/H+ exchanger for tumor growth.

  1989cited by this paper
• Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

  1989cited by this paper
• Vascular endothelial growth factor is a secreted angiogenic mitogen.

  1989cited by this paper
• Invasion and metastasis following orthotopic transplantation of human pancreatic cancer in the nude mouse

  1989cited by this paper
• pH distributions in spontaneous and isotransplanted rat tumours.

  1988cited by this paper
• The relevance of tumour pH to the treatment of malignant disease.

  1984cited by this paper
• Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

  1983cited by this paper
• Measurement of magnetocrystalline anisotropy torque in sheared crystals

  1978cited by this paper
• Measurement of flow dynamics in the microcirculation.

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