Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-05-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1407001111PMID 24821797PMCID PMC4040621
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetics and Pathogenesis of Inflammatory Bowel Disease.

  2016cited by this paper
• Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

  2014cited by this paper
• Conventional CD4+ T cells regulate IL-22 producing intestinal innate lymphoid cells

  2014influential reference
• A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

  2014cited by this paper
• NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.

  2014cited by this paper
• Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

  2013cited by this paper
• Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

  2013cited by this paper
• Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.

  2013cited by this paper
• Paneth cells as a site of origin for intestinal inflammation

  2013cited by this paper
• Autophagy and intestinal homeostasis.

  2013cited by this paper
• Complex roles of caspases in the pathogenesis of inflammatory bowel disease.

  2013cited by this paper
• Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

  2013cited by this paper
• A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways

  2013cited by this paper
• A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

  2012cited by this paper
• Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

  2012cited by this paper
• Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease

  2012cited by this paper
• The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium.

  2012cited by this paper
• Genetics and pathogenesis of inflammatory bowel disease

  2011cited by this paper
• Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

  2011cited by this paper
• Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

  2011cited by this paper
• Galectin-8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

  2011cited by this paper
• Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

  2011cited by this paper
• Image-Based Genome-Wide siRNA Screen Identifies Selective Autophagy Factors

  2011cited by this paper
• NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

  2010cited by this paper
• Network organization of the human autophagy system

  2010cited by this paper
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

  2010cited by this paper
• Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

  2010cited by this paper
• Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

  2010cited by this paper
• Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy

  2009cited by this paper
• A Novel Hybrid Yeast-Human Network Analysis Reveals an Essential Role for FNBP1L in Antibacterial Autophagy 1

  2009cited by this paper
• Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini.

  2008cited by this paper
• Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.

  2008cited by this paper
• Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

  2008influential reference
• Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

  2008cited by this paper
• A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

  2008cited by this paper
• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

  2007cited by this paper
• Escape of Intracellular Shigella from Autophagy

  2005cited by this paper
• Cloning and Analysis of Human Apg16L

  2004cited by this paper

• Mitophagy-related molecular signatures in ulcerative colitis revealed by machine learning and molecular dynamics

  2026cites this paper
• AXL-dependent autophagy impairment differentiates monocyte-derived macrophages from Crohn's disease and intestinal tuberculosis.

  2026cites this paper
• Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis.

  2026cites this paper
• Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity

  2025cites this paper
• Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease

  2025cites this paper
• Chronic enteritis triggered by diet westernization is driven by epithelial ATG16L1-mediated autophagy

  2025cites this paper
• The intestinal barrier: a pivotal role in health, inflammation, and cancer.

  2025cites this paper
• BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis

  2025cites this paper
• Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD

  2025cites this paper
• Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation

  2025cites this paper
• The role of ATG16L1 in Crohn’s disease and the structural alteration mechanisms and functional consequences of the rs2241880 variant

  2025cites this paper
• Balancing immunity: disease risk mutation can be beneficial.

  2025cites this paper
• The clinical application value of the biomarkers based on autophagy screening in the diagnosis and monitoring of inflammatory bowel disease in pediatric patients

  2025cites this paper
• ATG16L1 WD domain and linker regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection

  2025cites this paper
• Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages

  2025cites this paper
• A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals

  2025cites this paper
• Calcitriol/Vitamin D Receptor Ameliorates Fructose-Induced Enteritis-Hepatitis Axis Dysregulation in Mice.

  2025cites this paper
• Autophagy and Bacterial infections

  2025cites this paper
• New insights into Th9 cells in inflammatory bowel diseases.

  2025cites this paper
• Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection.

  2025cites this paper
• Resveratrol alleviates acute lung injury in mice by promoting Pink1/Parkin-related mitophagy and inhibiting NLRP3 inflammasome activation.

  2024cites this paper
• Black carp ATG16L1 negatively regulates STING-mediated antiviral innate immune response.

  2024cites this paper
• The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk

  2024cites this paper
• Association between ATG16L1 rs2241880(T300A) and rs4663421 and ANCA‑associated vasculitis in the Guangxi population of China: Propensity score matching analysis

  2024cites this paper
• Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection

  2024influential citation
• Function of autophagy genes in innate immune defense against mucosal pathogens.

  2024cites this paper
• Defective Atg16l1 in intestinal epithelial cells links to altered fecal microbiota and metabolic shifts during pregnancy in mice

  2024cites this paper
• BCL2 regulates antibacterial autophagy in the intestinal epithelium

  2024cites this paper
• The Role of Gut Microbiota, Immune System, and Autophagy in the Pathogenesis of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutic Approaches

  2024cites this paper
• Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the Gut

  2024cites this paper
• Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.

  2024cites this paper
• Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms

  2024influential citation
• Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell Niche

  2024cites this paper
• Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.

  2024cites this paper
• Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin.

  2024cites this paper
• Therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles: A focus on inflammatory bowel disease

  2024cites this paper
• Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8+ T cells

  2024cites this paper
• The role of autophagy in RIP1 mediated cell death and intestinal inflammation.

  2024cites this paper
• BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking

  2024cites this paper
• Mitochondrial quality control in human health and disease

  2024cites this paper
• Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies.

  2024cites this paper
• Commensal microbiome and gastrointestinal mucosal immunity: Harmony and conflict with our closest neighbor

  2024cites this paper
• Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia

  2024cites this paper
• New insights into the interplay between autophagy, gut microbiota and insulin resistance in metabolic syndrome.

  2024cites this paper
• Establishment and analysis of a novel diagnostic model for systemic juvenile idiopathic arthritis based on machine learning

  2024cites this paper
• Regulation of Mitochondrial Quality Control of Intestinal Stem Cells in Homeostasis and Diseases

  2024cites this paper
• The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy

  2024cites this paper
• Multifaceted involvements of Paneth cells in various diseases within intestine and systemically

  2023cites this paper
• Mapping pQTLs of circulating inflammatory proteins identifies drivers of and novel therapeutic targets

  2023cites this paper
• The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease

  2023cites this paper
• Autophagy genes in biology and disease

  2023cites this paper
• Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites

  2023cites this paper
• Modulation of the immunity and inflammation by autophagy

  2023cites this paper
• Autophagy and Apoptosis in Inflammatory Bowel Disease

  2023cites this paper
• The interplay between the microbiota, diet and T regulatory cells in the preservation of the gut barrier in inflammatory bowel disease

  2023cites this paper
• Intestinal epithelial Atg16l1 influences pregnancy-induced fecal microbiota shifts in mice

  2023cites this paper
• HuR and Its Interactions with Noncoding RNAs in Gut Epithelium Homeostasis and Diseases.

  2023cites this paper
• Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

  2023cites this paper
• ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

  2023cites this paper
• Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn’s Disease

  2023cites this paper
• ATG16L1 protects from IFN-γ-induced cell death in the small intestinal crypt.

  2023cites this paper
• The protein kinase R modifies gut physiology to limit colitis

  2023cites this paper
• Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination

  2023cites this paper
• Deciphering the different phases of preclinical inflammatory bowel disease

  2023cites this paper
• Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives

  2023cites this paper
• Controlling Intestinal Infections and Digestive Disorders Using Probiotics

  2023cites this paper
• β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitis

  2023cites this paper
• Effect of Nano-selenium on Biological Mechanism of Goblet Cells of the Small Intestine Within Laying Hen

  2023cites this paper
• Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-related disease risk and novel therapeutic targets

  2023cites this paper
• The Role of AMPK Signaling in Ulcerative Colitis

  2023cites this paper
• Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity

  2023cites this paper
• Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis

  2023cites this paper
• Paneth cells as the cornerstones of intestinal and organismal health: a primer

  2022cites this paper
• Proteolytic processing in autophagy

  2022cites this paper
• The potential importance of Autophagy genes expression profile dysregulation and ATG polymorphisms in COVID‐19 pathogenesis

  2022cites this paper
• AR12 increases BAG3 expression via ER stress signaling which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

  2022cites this paper
• Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape

  2022cites this paper
• Interactions of Autophagy and the Immune System in Health and Diseases

  2022cites this paper
• Autophagy in the gastrointestinal system and cross talk with microbiota

  2022cites this paper
• AR12 increases BAG3 expression which is essential for Tau and APP degradation via LC3-associated phagocytosis and macroautophagy

  2022cites this paper
• IBD-Associated Atg16L1T300A Polymorphism Regulates Commensal Microbiota of the Intestine

  2022cites this paper
• Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update

  2022cites this paper
• Autophagy on the road to longevity and aging

  2022cites this paper
• The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death

  2022cites this paper
• Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.

  2022cites this paper
• Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy

  2022influential citation
• mTOR-Mediated Autophagy Regulates Fumonisin B1-Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro.

  2022cites this paper
• LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients

  2022cites this paper
• Association of ATG16L1 rs2241880 and TP53 rs1042522 with characteristics and course of diffuse large B-cell lymphoma.

  2022cites this paper
• The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways

  2022cites this paper
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

  2022cites this paper
• Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption

  2022cites this paper
• Alterations of autophagic and innate immune responses by the Crohn’s disease-associated ATG16L1 mutation

  2022cites this paper
• Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases

  2022cites this paper
• Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival

  2022cites this paper
• Transcription factor TFEB cell-autonomously modulates Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo susceptibility to intestinal epithelial cell injury in vivo

  2022cites this paper
• ATG16L1 WD40 domain-dependent IL10R (interleukin 10 receptor) signaling is insensitive to the T300A Crohn disease risk polymorphism

  2022influential citation
• The Role of Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases

  2022cites this paper
• Intestinal epithelial cell autophagy deficiency suppresses inflammation-associated colon tumorigenesis

  2022cites this paper
• Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media

  2022cites this paper