A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Clinical Investigation

• Publication date

  1989-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1172/JCI114318PMID 2808700PMCID PMC304007
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.

  1988cited by this paper
• Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of different molecular weight.

  1988cited by this paper
• Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder.

  1988cited by this paper
• ROLE OF PLATELET MEMBRANE GLYCOPROTEIN IV IN PLATELET-COLLAGEN INTERACTION: A MICROTITER ASSAY TO STUDY PLATELET ADHERENCE

  1987cited by this paper
• A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia.

  1987cited by this paper
• Specific adsorption of a platelet membrane glycoprotein by human insoluble collagen.

  1986cited by this paper
• [Collagen adhesion abnormality].

  1986cited by this paper
• Platelet factor XIII. The collagen receptor?

  1986cited by this paper
• Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

  1985cited by this paper
• Selective staining of human platelet glycoproteins using nitrocellulose transfer of electrophoresed proteins and peroxidase-conjugated lectins.

  1984cited by this paper
• Interaction of human platelet membrane glycoproteins with collagen and lectins.

  1984cited by this paper
• Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen.

  1982cited by this paper
• Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis.

  1982cited by this paper
• Isolation and purification of collagen alpha 1(I) receptor from human platelet membrane.

  1982cited by this paper
• Purification and preliminary physicochemical characterization of human platelet membrane glycoprotein V.

  1981cited by this paper
• Surface labelling as a tool to determine structure-function relationships of platelet plasma membrane glycoproteins.

  1980cited by this paper
• Surface Labeling as a Tool to Determine Structure-Function Relationships of Platelet Plasma Membrane Glycoproteins

  1979cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Affinity isolation and characterization of immunoglobulin G Fc fragment-binding glycoprotein from human blood platelets.

  1979cited by this paper
• Evidence that fibronectin is the collagen receptor on platelet membranes.

  1978cited by this paper
• Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

  1977cited by this paper
• Platelet adherence to collagen: a simple, reproducible, quantitative method for its measurement.

  1977cited by this paper
• Effect of trypsin on the exposed polypeptides and glycoproteins in the human platelet membrane.

  1972cited by this paper
• Enzymatic basis for platelet: collagen adhesion as the primary step in haemostasis.

  1971cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• A familialdefect in platelet function associated with imapired release of adenosine diphosphate.

  1969cited by this paper

• Humanized murine models of platelet function.

  2025cites this paper
• Clinicopathological Spectrum of Functional Platelet Disorders Diagnosed Using Light Transmission Aggregometry

  2025cites this paper
• Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure

  2025cites this paper
• Blocking platelet glycoprotein VI (GPVI) as a promising anti-thrombotic treatment.

  2025cites this paper
• Antiplatelet activity of Alisma orientale extract through inhibiting glycoprotein VI and its downstream signaling pathways

  2025cites this paper
• STEMI Antithrombotic Therapy: The Evolving Role of P2Y12 Inhibitor Pretreatment in Contemporary Practice

  2024cites this paper
• De l’identification d’un récepteur plaquettaire (GPVI) au développement d’un candidat antiplaquettaire découplé du risque hémorragique

  2024cites this paper
• Molecular mechanisms driving the interactions between platelet and gastric cancer cells during peritoneal dissemination

  2024cites this paper
• Recurrent Cerebral Hemorrhaging with Platelet Dysfunction Accompanied by Anti-glycoprotein VI Autoantibodies in a Patient with TAFRO Syndrome

  2024cites this paper
• GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease

  2024cites this paper
• Knockdown of tmem183a in Zebrafish Causes Thrombocytopenia and Reduces Coagulation Factors, Disrupting Hemostasis

  2024cites this paper
• Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI

  2023cites this paper
• Novel strategies in antithrombotic therapy: targeting thrombosis while preserving hemostasis

  2023cites this paper
• Plasma Soluble Glycoprotein VI, Platelet Function, Bleeding, and Ischemic Events in Patients Undergoing Elective Percutaneous Coronary Intervention

  2023cites this paper
• Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer

  2023cites this paper
• Screening and diagnosis of inherited platelet disorders

  2022cites this paper
• Evaluating fostamatinib disodium as a treatment option for immune thrombocytopenia in adult patients

  2022influential citation
• Structural insights into collagen-binding by platelet receptor Glycoprotein VI.

  2022cites this paper
• Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner

  2022cites this paper
• GPR56, a novel platelet collagen receptor that loves stress

  2021cites this paper
• Platelet Activation through GPVI Receptor: Variability of the Response

  2021cites this paper
• Snake Venoms in Diagnostic Hemostasis and Thrombosis

  2021cites this paper
• Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease: The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial.

  2021cites this paper
• Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury

  2021cites this paper
• Platelet Activation through GPVI Receptor: Variability of the Response

  2021cites this paper
• Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

  2021cites this paper
• Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis

  2021cites this paper
• Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment

  2021cites this paper
• A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbα and glycoprotein GPVI.

  2021cites this paper
• The molecular basis of immune-based platelet disorders.

  2020cites this paper
• Inherited platelet diseases with normal platelet count: phenotypes, genotypes and diagnostic strategy

  2020cites this paper
• Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy

  2020cites this paper
• Inherited Platelet Disorders: Diagnosis and Management.

  2020cites this paper
• Towards the Therapeutic Use of Thrombospondin 1/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent

  2020cites this paper
• Glycoprotein VI - Novel target in antiplatelet medication.

  2020cites this paper
• Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

  2020cites this paper
• Progress Towards a Glycoprotein VI Modulator for the Treatment of Thrombosis.

  2020cites this paper
• Novel scientific approaches and future research directions in understanding ITP

  2020cites this paper
• Platelet receptor glycoprotein VI

  2020cites this paper
• Anti-Oncogenic Activities Exhibited By Secretomes Of Mesenchymal Stem Cells Are Mediated By Modulation Of KITLG and DKK1 Genes In Glioma Stem Cells.

  2020cites this paper
• Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro

  2020cites this paper
• Qualitative disorders of platelets and vasculature

  2020cites this paper
• Platelet immunophenotyping in health and inherited bleeding disorders, a review and practical hints

  2020cites this paper
• Clinical significance of altered collagen-receptor functioning in platelets with emphasis on glycoprotein VI.

  2019cites this paper
• From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks

  2019cites this paper
• Emerging Factors Implicated in Fibrotic Organ–Associated Thrombosis: The Case of Two Organs

  2019cites this paper
• Dichotomy of the function of DDR1 in cells and disease progression.

  2019cites this paper
• Peripheral serotonin causes dengue virus-induced thrombocytopenia through 5HT2 receptors.

  2019cites this paper
• Revacept, a Novel Inhibitor of Platelet Adhesion, in Patients Undergoing Elective PCI—Design and Rationale of the Randomized ISAR-PLASTER Trial

  2019cites this paper
• Platelet biology of the rapidly failing lung

  2019cites this paper
• Laboratory investigation of platelet function in patients with mild bleeding disorders

  2018cites this paper
• Role of platelets and platelet receptors in cancer metastasis

  2018cites this paper
• Proteolytic processing of platelet receptors

  2018cites this paper
• Glycoprotein VI in securing vascular integrity in inflamed vessels

  2018cites this paper
• Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram

  2018cites this paper
• The Role of 12-Lipoxygenase in the Regulation of Platelet Function

  2018cites this paper
• The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation

  2017cites this paper
• Novel Glycoprotein VI Antagonists as Antithrombotics: Synthesis, Biological Evaluation, and Molecular Modeling Studies on 2,3-Disubstituted Tetrahydropyrido(3,4-b)indoles.

  2017cites this paper
• Alpha-Dystroglycan Plays Functional Roles in Platelet Aggregation and Thrombus Growth

  2017cites this paper
• HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Influence of Fibrillar Collagen Structure on the Mechanisms of Platelet Thrombus Formation Under Flow

  2017cites this paper
• Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.

  2017cites this paper
• Molecular modelling studies in explaining the higher GPVI antagonistic activity of the racemic 2-(4-methoxyphenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide than its enantiomers$

  2017cites this paper
• Platelet “first responders” in wound response, cancer, and metastasis

  2017cites this paper
• Platelets in Arterial Thrombosis

  2017cites this paper
• Platelet Activation Under Conditions of Flow

  2017cites this paper
• Inhibitors of Platelet Adhesion to VWF and Collagen

  2017cites this paper
• Platelet-targeted pharmacologic treatments as anti-cancer therapy

  2017cites this paper
• Platelets and Coagulation

  2017cites this paper
• Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

  2017cites this paper
• Association of polymorphisms of platelet receptors GPIa (807C>T), GPVI (13254T>C), and P2Y12 (34C>T and H1/H2 haplotype) with increased risk of periprocedural bleeding in patients undergoing coronary angiography/percutaneous coronary intervention

  2017cites this paper
• New Concepts and Mechanisms of Platelet Activation Signaling.

  2017influential citation
• Vitamin C in Health and Disease

  2017cites this paper
• Platelet Adhesive Protein Defect Disorders

  2017cites this paper
• 119 – Platelet–Vessel Wall Interactions

  2017cites this paper
• Anti‐glycoprotein VI mediated immune thrombocytopenia: An under‐recognized and significant entity?

  2017cites this paper
• Platelet Membrane Glycoproteins

  2017cites this paper
• Characterization and Diagnostic Work-up of a Patient with Functionally Impaired Platelet GP6

  2017cites this paper
• Expression and purification of the extracellular domains of human glycoprotein VI (GPVI) and the receptor for advanced glycation end products (RAGE) from Rattus norvegicus in Leishmania tarentolae

  2017cites this paper
• Autoimmune Thrombocytopenia　

  2017cites this paper
• Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet

  2017cites this paper
• Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

  2016cites this paper
• The role of GPVI and CLEC-2 in platelet activation by miscellaneous ligands

  2016cites this paper
• An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

  2016cites this paper
• La trombocitopenia como factor de riesgo en el ductus arteriosus persistente del recién nacido prematuro

  2016cites this paper
• HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Genetic and Pharmacological Analyses of Syk Function in aIIbb3 Signaling in Platelets

  2016cites this paper
• A Novel Approach To Antiplatelet Therapy: Targeting Protease Activated Receptor 4

  2016cites this paper
• Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke

  2016cites this paper
• cAMP signaling reverses platelet spreading via inhibition of RhoA

  2016cites this paper
• Platelets and Their Interactions with Other Immune Cells.

  2015cites this paper
• Diagnostik und Therapie atherosklerotischer Plaques mittels Ultraschallkontrastmittel am Mausmodell

  2015influential citation
• Surveillance of cell and tissue perturbation by receptors in the LRC

  2015cites this paper
• Fibrin activates GPVI in human and mouse platelets.

  2015cites this paper
• Influence des peptides d'élastine dans le diabète de type 2 et la thrombose et caractérisation biochimique et fonctionnelle de la sous-unité Neuraminidase-1 du complexe récepteur de l'élastine

  2015cites this paper
• Metrological techniques to study pirmary and secondar hemostasis

  2015cites this paper
• Comparison of platelet receptors P2Y12, GPIIB/IIIA, GPVI, and GPIBα between the Cape chacma baboon and the human

  2015cites this paper
• Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis, platelet activation and antithrombotic therapy.

  2015cites this paper
• The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents

  2015cites this paper
• Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

  2015cites this paper
• Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies

  2015cites this paper
• Ibrutinib Inhibits Platelet Integrin &agr;IIb&bgr;3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen

  2015cites this paper