The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Gastroenterology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1053/GAST.2003.50022PMID 12512025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The human capsaicin model of allodynia and hyperalgesia: sources of variability and methods for reduction.

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• Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations.

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• Allodynia evoked by intrathecal administration of prostaglandin F2&agr; to conscious mice

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• Analysis of serial measurements in medical research.

  1990cited by this paper
• The short‐form McGill pain questionnaire

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• Indomethacin blocks central nociceptive effects of PGF2 alpha.

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• Evidence for a central component of post-injury pain hypersensitivity

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• The hyperalgesic effects of prostacyclin and prostaglandin E2.

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• INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN

  1976cited by this paper
• A clinical test for esophagitis.

  1958cited by this paper

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