Site-Specific Molecular Diffusion in Articular Cartilage Measured using Fluorescence Recovery after Photobleaching

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Annals of Biomedical Engineering

• Publication date

  2003-07-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1114/1.1581879PMID 12971608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Static compression is associated with decreased diffusivity of dextrans in cartilage explants.

  2000cited by this paper
• Electron microscopic stereological study of collagen fibrils in bovine articular cartilage: volume and surface densities are best obtained indirectly (from length densities and diameters) using isotropic uniform random sampling

  1999cited by this paper
• Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.

  1999cited by this paper
• Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching.

  1998cited by this paper
• Local macromolecule diffusion coefficients in structurally non-uniform bacterial biofilms using fluorescence recovery after photobleaching (FRAP).

  1998cited by this paper
• Diffusive properties of immature articular cartilage.

  1998cited by this paper
• Effect of proteoglycan removal on solute mobility in articular cartilage.

  1997cited by this paper
• Translational Diffusion of Macromolecule-sized Solutes in Cytoplasm and Nucleus

  1997cited by this paper
• Ultrastructure of adult human articular cartilage matrix after cryotechnical processing

  1997cited by this paper
• Hindered diffusion of spherical macromolecules through dilute fibrous media

  1996cited by this paper
• Visualization of the diffusion of metal ions and organic molecules by magnetic resonance imaging of water.

  1996cited by this paper
• Visualisation of mass transport of small organic molecules and metal ions through articular cartilage by magnetic resonance imaging.

  1995cited by this paper
• Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis

  1994cited by this paper
• The structure, function and turnover of aggrecan, the large aggregating proteoglycan from cartilage.

  1994cited by this paper
• Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging

  1993cited by this paper
• Macromolecular diffusion in crowded solutions.

  1993cited by this paper
• Effects of temperature, concentration and articular surface removal on transient solute diffusion in articular cartilage

  1993cited by this paper
• Fluorescence photobleaching recovery in the confocal scanning light microscope

  1993cited by this paper
• Collagen fibril structure of normal, aging, and osteoarthritic cartilage

  1992cited by this paper
• Chondrons from articular cartilage. III. Morphologic changes in the cellular microenvironment of chondrons isolated from osteoarthritic cartilage.

  1991cited by this paper
• Three-dimensional collagen architecture in bovine articular cartilage.

  1991cited by this paper
• Influence of cyclic loading on the nutrition of articular cartilage.

  1990cited by this paper
• Structure and biology of cartilage and bone matrix noncollagenous macromolecules

  1989cited by this paper
• Quantitation of structural features characterizing weight‐ and less‐weight‐bearing regions in articular cartilage: A stereological analysis of medical femoral condyles in young adult rabbits

  1988cited by this paper
• Transient solute diffusion in articular cartilage.

  1987cited by this paper
• Molecular mobility and nucleocytoplasmic flux in hepatoma cells

  1986cited by this paper
• Probing the structure of cytoplasm

  1986cited by this paper
• Structure of proteoglycans from different layers of human articular cartilage.

  1983cited by this paper
• Variations in the composition of bovine hip articular cartilage with distance from the articular surface.

  1981cited by this paper
• Anisotropic molecular motion on cell surfaces.

  1979cited by this paper
• Changes in the hexosamine content and swelling ratio of articular cartilage as functions of depth from the surface.

  1976cited by this paper
• Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.

  1976cited by this paper
• Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport

  1975cited by this paper
• Distribution and diffusion of solutes in articular cartilage.

  1970cited by this paper

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• [Study on transport of small molecule rhodamine B within different layers of cartilage].

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