Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression

The Golgi protein RhoBTB3 in complex with CUL3 and RBX1 promotes Cyclin E ubiquitylation to allow its turnover during S phase and progression through the cell cycle.

• Publication year

  2013

• Venue

  Journal of Cell Biology

• Publication date

  2013-10-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201305158PMID 24145166PMCID 3812982
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fbw7α and Fbw7γ Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation

  2012cited by this paper
• NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway

  2012cited by this paper
• Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome

  2012cited by this paper
• Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.

  2012cited by this paper
• An OBSL1-Cul7Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning

  2011influential reference
• Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery.

  2011cited by this paper
• The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle.

  2011cited by this paper
• Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients

  2011cited by this paper
• Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

  2010cited by this paper
• Report of Cyclin E-Cdk 2 Is Required for Initiation of DNA Synthesis

  2010cited by this paper
• Golgi Partitioning Controls Mitotic Entry through Aurora-A Kinase

  2010cited by this paper
• Identification of substrates for cyclin dependent kinases.

  2010influential reference
• Endoreplication: polyploidy with purpose.

  2009cited by this paper
• F-Box Protein FBXO31 Mediates Cyclin D1 Degradation to Induce G1 Arrest Following DNA Damage

  2009cited by this paper
• The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

  2009cited by this paper
• RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.

  2009influential reference
• Rho GTPases of the RhoBTB subfamily and tumorigenesis

  2008influential reference
• FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

  2008cited by this paper
• A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins*S

  2008cited by this paper
• Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.

  2008influential reference
• The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

  2007cited by this paper
• Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

  2007cited by this paper
• Constitutive Turnover of Cyclin E by Cul3 Maintains Quiescence

  2007influential reference
• Identification of Genes Selectively Regulated by IFNs in Endothelial Cells1

  2007cited by this paper
• Kinase-independent function of cyclin E.

  2007influential reference
• p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis.

  2006cited by this paper
• Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase.

  2006cited by this paper
• Centrosome abnormalities are frequently observed in non‐small‐cell lung cancer and are associated with aneuploidy and cyclin E overexpression

  2006cited by this paper
• Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation.

  2006cited by this paper
• A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling.

  2006cited by this paper
• Born to bind: the BTB protein–protein interaction domain

  2006cited by this paper
• Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.

  2006cited by this paper
• Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.

  2006cited by this paper
• The BTB-kelch Protein LZTR-1 Is a Novel Golgi Protein That Is Degraded upon Induction of Apoptosis*

  2006cited by this paper
• Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

  2006cited by this paper
• COSMIC 2005

  2006cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways.

  2005cited by this paper
• A tentative classification of centrosome abnormalities in cancer

  2005cited by this paper
• Function and regulation of cullin–RING ubiquitin ligases

  2005cited by this paper
• Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling

  2005cited by this paper
• Cyclin E in normal and neoplastic cell cycles

  2005influential reference
• Targeting Rab GTPases to distinct membrane compartments

  2004cited by this paper
• How cells coordinate growth and division.

  2004cited by this paper
• Inactivation of hCDC4 can cause chromosomal instability

  2004cited by this paper
• A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry

  2004influential reference
• Human RAS Superfamily Proteins and Related GTPases

  2004cited by this paper
• Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells

  2004cited by this paper
• BTB proteins as henchmen of Cul3-based ubiquitin ligases

  2003cited by this paper
• IFN-γ inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway

  2003cited by this paper
• RAS oncogenes: the first 30 years

  2003cited by this paper
• The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

  2003cited by this paper
• Cell-cycle-specific Golgi fragmentation: how and why?

  2003cited by this paper
• BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3

  2003cited by this paper
• Cyclin-Dependent Kinases and S Phase Control in Mammalian Cells

  2003cited by this paper
• IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway.

  2003cited by this paper
• Cyclin E ablation in the mouse.

  2003cited by this paper
• Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

  2003cited by this paper
• Centrosome amplification and the development of cancer

  2002cited by this paper
• Fragmentation and dispersal of the pericentriolar Golgi complex is required for entry into mitosis in mammalian cells.

  2002cited by this paper
• Cyclin E and survival in patients with breast cancer.

  2002cited by this paper
• Cyclins in breast cancer: too much of a good thing

  2002cited by this paper
• Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4

  2002cited by this paper
• RHO–GTPases and cancer

  2002cited by this paper
• Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

  2002cited by this paper
• The Localization of Human Cyclins B1 and B2 Determines Cdk1 Substrate Specificity and Neither Enzyme Requires Mek to Disassemble the Golgi Apparatus

  2001cited by this paper
• Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCFFbw7 Ubiquitin Ligase

  2001influential reference
• Accumulation of Cyclin E Is Not a Prerequisite for Passage through the Restriction Point

  2001influential reference
• Characterization of Cdk2-Cyclin E Complexes in Plasma Membrane and Endosomes of Liver Parenchyma

  2000cited by this paper
• Deregulated cyclin E induces chromosome instability

  1999cited by this paper
• Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

  1999influential reference
• Protein prenylation: molecular mechanisms and functional consequences.

  1996cited by this paper
• Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

  1995cited by this paper
• A cell cycle-regulated inhibitor of cyclin-dependent kinases.

  1994cited by this paper
• Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

  1994cited by this paper
• Association of human cyclin E with a periodic G1-S phase protein kinase.

  1992cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

  1992cited by this paper

• Diosmetin attenuates the ubiquitination of epidermal hypoxia-inducible factor 1 alpha by diminishing the formation of RhoBTB3/PHD2 complex in ultraviolet radiation-induced sunburn in mice.

  2025cites this paper
• Molecular basis and current insights of atypical Rho small GTPase in cancer

  2024cites this paper
• Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues

  2024cites this paper
• RhoBTB3 Functions as a Novel Regulator of Autophagy by Suppressing AMBRA1 Stability

  2024cites this paper
• Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex

  2024cites this paper
• Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing Pathways in Neurodegenerative Disorders and Cancer.

  2024cites this paper
• The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

  2023cites this paper
• Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis.

  2023cites this paper
• Genome wide association study identifies novel candidate genes for growth and body conformation traits in goats

  2022cites this paper
• High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

  2021influential citation
• Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta.

  2021cites this paper
• RhoGTPase Signalling in Cancer Progression and Dissemination.

  2021cites this paper
• RhoBTB3 Regulates Proliferation and Invasion of Breast Cancer Cells via Col1a1

  2021influential citation
• RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells

  2020cites this paper
• Tumor-specific genetic profiling and therapy in biomedicine

  2020cites this paper
• Emerging roles for Rho GTPases operating at the Golgi complex

  2020cites this paper
• Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation.

  2020cites this paper
• Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E

  2019cites this paper
• Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3

  2019cites this paper
• Multifaceted Rho GTPase Signaling at the Endomembranes

  2019cites this paper
• Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases

  2019cites this paper
• Alterations in platelet alpha granule secretion and 2 adhesion on collagen under flow in mice lacking the 3 atypical Rho GTPase RhoBTB 3 4

  2019cites this paper
• Functional analysis of Cullin 3 E3 ligases in tumorigenesis.

  2018cites this paper
• RHOBTB3 (Rho-related BTB domain containing 3)

  2018influential citation
• SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

  2018cites this paper
• An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

  2018cites this paper
• Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

  2018cites this paper
• The Cul3 Ubiquitin Ligase: An Essential Regulator of Diverse Cellular Processes

  2017influential citation
• Lidocaine inhibits the proliferation of lung cancer by regulating the expression of GOLT1A

  2017cites this paper
• The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B

  2017cites this paper
• Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.

  2017cites this paper
• Gankyrin promotes the proliferation of gastric cancer and is associated with chemosensitivity

  2017cites this paper
• The pineal gland: A model for adrenergic modulation of ubiquitin ligases

  2017cites this paper
• Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis

  2016influential citation
• Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

  2016cites this paper
• Rho Signaling in Dictyostelium discoideum.

  2016cites this paper
• Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment

  2016cites this paper
• Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation

  2015cites this paper
• A new mitochondrial pool of cyclin E, regulated by Drp1, is linked to cell-density-dependent cell proliferation

  2015cites this paper
• RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

  2015cites this paper
• Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer

  2015cites this paper
• Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm

  2015cites this paper
• CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation

  2015cites this paper
• Regulation of vascular function: Roles for Cullin-3 and RhoBTB1 in PPARgamma-mediated blood pressure control

  2015cites this paper
• Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain

  2014influential citation
• Uncovering the role of host Cullin 3 during Plasmodium berghei liver stage infection

  2014cites this paper
• A CULLINary ride across the secretory pathway: more than just secretion.

  2014cites this paper
• Putting Cyclin E in the trash

  2013cites this paper