Preclinical risk assessment of drug‐induced hypo‐ and hyperprolactinemia

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Applied Toxicology

• Publication date

  2011-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jat.1723PMID 21887789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Prolactin in breast and prostate cancer: molecular and genetic perspectives.

  2011cited by this paper
• Prolactin serum levels and breast cancer: relationships with risk factors and tumour characteristics among pre- and postmenopausal women in a population-based case–control study from Poland

  2010cited by this paper
• Polymorphism of the extrapituitary prolactin promoter and systemic sclerosis

  2010cited by this paper
• Proceedings of the 5th Copenhagen Workshop on endocrine disrupters: ubiquitous endocrine disrupters and possible human health effects. Preface.

  2010cited by this paper
• Proceedings of the 5th Copenhagen Workshop on Endocrine Disrupters: Ubiquitous endocrine disrupters and possible human health effects, 20-22 May 2009.

  2010cited by this paper
• Collaborative work on evaluation of ovarian toxicity. 9) Effects of 2- or 4-week repeated dose studies and fertility study of di(2-ethylhexyl)adipate (DEHA) in female rats.

  2009cited by this paper
• Genotoxic and carcinogenic effects of antipsychotics and antidepressants.

  2009cited by this paper
• Imipramine induced elevation of prolactin levels in patients with HIV/AIDS improved their immune status.

  2009cited by this paper
• [Endocrine disrupters: from toxicological investigation to biomarker characterization].

  2009cited by this paper
• Collaborative work on evaluation of ovarian toxicity. 17) Two- or four-week repeated-dose studies and fertility study of sulpiride in female rats.

  2009cited by this paper
• Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin.

  2009cited by this paper
• Pregnancy rate following bromocriptine treatment in infertile women with galactorrhea

  2009cited by this paper
• Prolactin and Breast Cancer Etiology: An Epidemiologic Perspective

  2008cited by this paper
• What can we learn from rodents about prolactin in humans?

  2008cited by this paper
• Adverse effects of prolactin in rodents and humans: breast and prostate cancer

  2008influential reference
• Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio.

  2008cited by this paper
• Drugs and prolactin

  2008cited by this paper
• The Rat Mammary Gland: Morphologic Changes as an Indicator of Systemic Hormonal Perturbations Induced by Xenobiotics

  2007influential reference
• Reproductive role of prolactin.

  2007cited by this paper
• Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal women

  2007cited by this paper
• Pathological gambling associated with cabergoline therapy in a patient with a pituitary prolactinoma.

  2007cited by this paper
• A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer.

  2007cited by this paper
• Identification of drug-induced hyper- or hypoprolactinemia in the female rat based on general and reproductive toxicity study parameters.

  2007influential reference
• Valvular heart disease and the use of dopamine agonists for Parkinson's disease.

  2007cited by this paper
• Dopamine agonists and the risk of cardiac-valve regurgitation.

  2007cited by this paper
• Hyperprolactinaemia as an adverse effect in regulatory and clinical toxicology: role in breast and prostate cancer

  2006cited by this paper
• A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D.

  2006cited by this paper
• Human relevance of rodent prolactin‐induced non‐genotoxic mammary carcinogenesis: prolactin involvement in human breast cancer and significance for toxicology risk assessments

  2005cited by this paper
• Relation of the neuroendocrine system to the development and growth of experimental mammary tumors

  2005cited by this paper
• Prolactin and the prolactin receptor: new targets of an old hormone

  2004cited by this paper
• Plasma Prolactin Concentrations and Risk of Postmenopausal Breast Cancer

  2004cited by this paper
• Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.

  2003cited by this paper
• Prolactin induces ERα-positive and ERα-negative mammary cancer in transgenic mice

  2003cited by this paper
• Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin.

  2003cited by this paper
• Prostate development and carcinogenesis in prolactin receptor knockout mice.

  2003cited by this paper
• Hyperprolactinemia and Schizophrenia: Mechanisms and Clinical Aspects

  2003cited by this paper
• Hyperprolactinemia in response to antipsychotic drugs: characterization across comparative clinical trials.

  2003cited by this paper
• The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

  2003cited by this paper
• Regulation of serum leptin and its role in the hyperphagia of lactation in the rat.

  2003cited by this paper
• Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice.

  2003cited by this paper
• Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences.

  2002cited by this paper
• Dopamine antagonists and the development of breast cancer.

  2002influential reference
• Body weight and fat deposition in prolactin receptor-deficient mice.

  2001cited by this paper
• Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice.

  2001cited by this paper
• A woman with isolated prolactin deficiency

  2001cited by this paper
• Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.

  2001cited by this paper
• Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice.

  2001cited by this paper
• Plasma prolactin and prostate cancer risk: A prospective study

  2001cited by this paper
• Prolactin gene-disruption arrests mammary gland development and retards T-antigen-induced tumor growth

  2000cited by this paper
• Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard.

  2000cited by this paper
• Strategies for handling unexpected endocrine findings in early safety assessment.

  2000cited by this paper
• Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation

  2000influential reference
• Rescue of Preimplantatory Egg Development and Embryo Implantation in Prolactin Receptor-Deficient Mice after Progesterone Administration.

  2000cited by this paper
• Prolactin as a local growth promoter in patients with breast cancer: GCRI experience.

  2000cited by this paper
• Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration.

  2000cited by this paper
• Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard.

  2000cited by this paper
• Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin.

  1999cited by this paper
• Should prolactin be reconsidered as a therapeutic target in human breast cancer?

  1999cited by this paper
• Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women.

  1999cited by this paper
• Stat5-Mediated Regulation of the Human Type II 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Gene: Activation by Prolactin

  1999cited by this paper
• Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice.

  1999cited by this paper
• Immune system development and function in prolactin receptor-deficient mice.

  1999cited by this paper
• Prolactin controls mammary gland development via direct and indirect mechanisms.

  1999cited by this paper
• Prolactin: A Hormone at the Crossroads of Neuroimmunoendocrinology

  1998cited by this paper
• Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

  1997cited by this paper
• Laboratory Animal Endocrinology: Hormonal Action, Control Mechanisms and Interactions with Drugs

  1997cited by this paper
• The effects of diet, overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, disease and toxicology.

  1997cited by this paper
• Androgen‐dependent expression of prolactin in rat prostate epithelium in vivo and in organ culture

  1997cited by this paper
• Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.

  1997cited by this paper
• Circulating nitric oxide levels in galactorrheic, hyperprolactinemic, amenorrheic women.

  1997cited by this paper
• Changes in plasma prolactin during SSRI treatment: evidence for a delayed increase in 5-HT neurotransmission

  1997cited by this paper
• The Effects of Diet, Ad Libitum Overfeeding, and Moderate Dietary Restriction on the Rodent Bioassay: The Uncontrolled Variable in Safety Assessment

  1996cited by this paper
• An in vivo battery for identifying endocrine modulators that are estrogenic or dopamine regulators.

  1996cited by this paper
• The Biosure Study: influence of composition of diet and food consumption on longevity, degenerative diseases and neoplasia in Wistar rats studied for up to 30 months post weaning.

  1995cited by this paper
• Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: I. Effects on Spontaneous Neoplasms

  1995cited by this paper
• Restoration of normal sperm characteristics in hypoprolactinemic infertile men treated with metoclopramide and exogenous human prolactin

  1995cited by this paper
• Diet, Overfeeding, and Moderate Dietary Restriction in Control Sprague-Dawley Rats: II. Effects on Age-Related Proliferative and Degenerative Lesions

  1995cited by this paper
• Structural variants of prolactin: occurrence and physiological significance.

  1995cited by this paper
• Immunosuppressive activity of bromocriptine on human T lymphocyte function in vitro

  1994cited by this paper
• Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines.

  1994cited by this paper
• Endocrine considerations in toxicologic pathology.

  1994cited by this paper
• Immunosuppressive property of bromocriptine on human B lymphocyte function in vitro

  1993cited by this paper
• Bromocriptine-induced implantation failure in mice: failure of the stud male to protect pregnancy.

  1992cited by this paper
• Progressive trabecular osteopenia in women with hyperprolactinemic amenorrhea.

  1992cited by this paper
• Isolated prolactin deficiency: a case report.

  1992cited by this paper
• Effects of chronic bromocriptine-induced hypoprolactinemia on plasma testosterone responses to human chorionic gonadotropin stimulation in normal men.

  1991cited by this paper
• Handbook of toxicologic pathology

  1991cited by this paper
• Genetic errors, cell proliferation, and carcinogenesis.

  1991cited by this paper
• Early indicators for carcinogenesis in sex-hormone-sensitive organs.

  1991cited by this paper
• Regulation of prolactin gene transcription in vivo: interactions between estrogen, pimozide, and alpha-ergocryptine.

  1990cited by this paper
• Neuroendocrine measures of dopaminergic function in chronic cocaine users.

  1990cited by this paper
• Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis.

  1990cited by this paper
• Naltrexone blocks nicotine-induced prolactin release.

  1989cited by this paper
• Endocrine and neurochemical actions of cocaine.

  1989cited by this paper
• Hypoprolactinemia as related to seminal quality and serum testosterone.

  1989cited by this paper
• Atlas of experimental toxicological pathology

  1989cited by this paper
• Characterization of the effects of the acute and chronic administration of phencyclidine on the release of adrenocorticotropin, corticosterone and prolactin in the rat: evidence for the differential development of tolerance.

  1989cited by this paper
• Bromokriptin beim chemotherapieresistenten, metastasierten Mammakarzinom

  1988cited by this paper
• [Bromocriptine in chemotherapy-resistant, metastatic breast cancer. Results of the GO-MC-BROMO 2/82 AIO Study].

  1988cited by this paper
• Tamoxifen plus bromocriptine versus tamoxifen plus placebo in advanced breast cancer: results of a double blind multicentre clinical trial.

  1988cited by this paper

• ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

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  2014influential citation
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  2014cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper